Does diabetes affect breast cancer survival?
Abstract Objectives The objective of this study is to investigate the influence of diabetes on breast cancer‐specific survival among women with breast cancer in Aotearoa/New Zealand. Methods This study included women diagnosed with invasive breast cancer between 2005 and 2020, with their information...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-03-01
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| Series: | Cancer Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cnr2.2040 |
| _version_ | 1797236879477702656 |
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| author | Ross Lawrenson Chunhuan Lao James Stanley Andrea Teng Marion Kuper‐Hommel Ian Campbell Jeremy Krebs Dianne Sika‐Paotonu Jonathan Koea Ineke Meredith Jason Gurney |
| author_facet | Ross Lawrenson Chunhuan Lao James Stanley Andrea Teng Marion Kuper‐Hommel Ian Campbell Jeremy Krebs Dianne Sika‐Paotonu Jonathan Koea Ineke Meredith Jason Gurney |
| author_sort | Ross Lawrenson |
| collection | DOAJ |
| description | Abstract Objectives The objective of this study is to investigate the influence of diabetes on breast cancer‐specific survival among women with breast cancer in Aotearoa/New Zealand. Methods This study included women diagnosed with invasive breast cancer between 2005 and 2020, with their information documented in the Te Rēhita Mate Ūtaetae—Breast Cancer Foundation National Register. Breast cancer survival curves for women with diabetes and those without diabetes were generated using the Kaplan–Meier method. The hazard ratio (HR) of breast cancer‐specific mortality for women with diabetes compared to women without diabetes was estimated using the Cox proportional hazards model. Results For women with diabetes, the 5‐year and 10‐year of cancer‐specific survival were 87% (95% CI: 85%–88%) and 79% (95% CI: 76%–81%) compared to 89% (95% CI: 89%–90%) and 84% (95% CI: 83%–85%) for women without diabetes. The HR of cancer‐specific mortality for patients with diabetes compared to those without diabetes was 0.99 (95% CI: 0.89–1.11) after adjustment for patient demographics, tumor characteristics, and treatments. Age at cancer diagnosis and cancer stage had the biggest impact on the survival difference between the two groups. When stratified by cancer stage, the cancer‐specific mortality between the two groups was similar. Conclusions While differences in survival have been identified for women with diabetes when compared to women without diabetes, these are attributable to age and the finding that women with diabetes tend to present with more advanced disease at diagnosis. We did not find any difference in survival between the two groups due to differences in treatment. |
| first_indexed | 2024-04-24T17:10:52Z |
| format | Article |
| id | doaj.art-ad4aae2c1175490a96810fdd4dd46540 |
| institution | Directory Open Access Journal |
| issn | 2573-8348 |
| language | English |
| last_indexed | 2024-04-24T17:10:52Z |
| publishDate | 2024-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Reports |
| spelling | doaj.art-ad4aae2c1175490a96810fdd4dd465402024-03-28T12:30:35ZengWileyCancer Reports2573-83482024-03-0173n/an/a10.1002/cnr2.2040Does diabetes affect breast cancer survival?Ross Lawrenson0Chunhuan Lao1James Stanley2Andrea Teng3Marion Kuper‐Hommel4Ian Campbell5Jeremy Krebs6Dianne Sika‐Paotonu7Jonathan Koea8Ineke Meredith9Jason Gurney10Medical Research Centre The University of Waikato Hamilton New ZealandMedical Research Centre The University of Waikato Hamilton New ZealandDepartment of Public Health University of Otago Wellington New ZealandDepartment of Public Health University of Otago Wellington New ZealandMedical Oncology Waikato Hospital Hamilton New ZealandDepartment of Surgery, Faculty of Health Sciences The University of Auckland Auckland New ZealandDepartment of Medicine University of Otago Wellington New ZealandDean's Department UOW & Division of Health Sciences University of Otago New ZealandGeneral Surgery Waitakere Hospital Auckland New ZealandGeneral Surgery Wakefield Hospital Wellington New ZealandDepartment of Public Health University of Otago Wellington New ZealandAbstract Objectives The objective of this study is to investigate the influence of diabetes on breast cancer‐specific survival among women with breast cancer in Aotearoa/New Zealand. Methods This study included women diagnosed with invasive breast cancer between 2005 and 2020, with their information documented in the Te Rēhita Mate Ūtaetae—Breast Cancer Foundation National Register. Breast cancer survival curves for women with diabetes and those without diabetes were generated using the Kaplan–Meier method. The hazard ratio (HR) of breast cancer‐specific mortality for women with diabetes compared to women without diabetes was estimated using the Cox proportional hazards model. Results For women with diabetes, the 5‐year and 10‐year of cancer‐specific survival were 87% (95% CI: 85%–88%) and 79% (95% CI: 76%–81%) compared to 89% (95% CI: 89%–90%) and 84% (95% CI: 83%–85%) for women without diabetes. The HR of cancer‐specific mortality for patients with diabetes compared to those without diabetes was 0.99 (95% CI: 0.89–1.11) after adjustment for patient demographics, tumor characteristics, and treatments. Age at cancer diagnosis and cancer stage had the biggest impact on the survival difference between the two groups. When stratified by cancer stage, the cancer‐specific mortality between the two groups was similar. Conclusions While differences in survival have been identified for women with diabetes when compared to women without diabetes, these are attributable to age and the finding that women with diabetes tend to present with more advanced disease at diagnosis. We did not find any difference in survival between the two groups due to differences in treatment.https://doi.org/10.1002/cnr2.2040breast cancercause of deathdiabetesmortalitysurvival |
| spellingShingle | Ross Lawrenson Chunhuan Lao James Stanley Andrea Teng Marion Kuper‐Hommel Ian Campbell Jeremy Krebs Dianne Sika‐Paotonu Jonathan Koea Ineke Meredith Jason Gurney Does diabetes affect breast cancer survival? Cancer Reports breast cancer cause of death diabetes mortality survival |
| title | Does diabetes affect breast cancer survival? |
| title_full | Does diabetes affect breast cancer survival? |
| title_fullStr | Does diabetes affect breast cancer survival? |
| title_full_unstemmed | Does diabetes affect breast cancer survival? |
| title_short | Does diabetes affect breast cancer survival? |
| title_sort | does diabetes affect breast cancer survival |
| topic | breast cancer cause of death diabetes mortality survival |
| url | https://doi.org/10.1002/cnr2.2040 |
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