Natural Small Molecules in Breast Cancer Treatment: Understandings from a Therapeutic Viewpoint
Breast cancer (BrCa) is the most common malignancy in women and the second most significant cause of death from cancer. BrCa is one of the most challenging malignancies to treat, and it accounts for a large percentage of cancer-related deaths. The number of cases requiring more effective BrCa therap...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/7/2165 |
| _version_ | 1797438403187310592 |
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| author | Md. Rezaul Islam Fahadul Islam Mohamed H. Nafady Muniya Akter Saikat Mitra Rajib Das Humaira Urmee Sheikh Shohag Aklima Akter Kumarappan Chidambaram Fahad A. Alhumaydhi Talha Bin Emran Simona Cavalu |
| author_facet | Md. Rezaul Islam Fahadul Islam Mohamed H. Nafady Muniya Akter Saikat Mitra Rajib Das Humaira Urmee Sheikh Shohag Aklima Akter Kumarappan Chidambaram Fahad A. Alhumaydhi Talha Bin Emran Simona Cavalu |
| author_sort | Md. Rezaul Islam |
| collection | DOAJ |
| description | Breast cancer (BrCa) is the most common malignancy in women and the second most significant cause of death from cancer. BrCa is one of the most challenging malignancies to treat, and it accounts for a large percentage of cancer-related deaths. The number of cases requiring more effective BrCa therapy has increased dramatically. Scientists are looking for more productive agents, such as organic combinations, for BrCa prevention and treatment because most chemotherapeutic agents are linked to cancer metastasis, the resistance of the drugs, and side effects. Natural compounds produced by living organisms promote apoptosis and inhibit metastasis, slowing the spread of cancer. As a result, these compounds may delay the spread of BrCa, enhancing survival rates and reducing the number of deaths caused by BrCa. Several natural compounds inhibit BrCa production while lowering cancer cell proliferation and triggering cell death. Natural compounds, in addition to therapeutic approaches, are efficient and potential agents for treating BrCa. This review highlights the natural compounds demonstrated in various studies to have anticancer properties in BrCa cells. Future research into biological anti-BrCa agents may pave the way for a new era in BrCa treatment, with natural anti-BrCa drugs playing a key role in improving BrCa patient survival rates. |
| first_indexed | 2024-03-09T11:37:23Z |
| format | Article |
| id | doaj.art-ad4b1f7a56a945f7ab7df8ff1e5f6b7b |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T11:37:23Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-ad4b1f7a56a945f7ab7df8ff1e5f6b7b2023-11-30T23:40:28ZengMDPI AGMolecules1420-30492022-03-01277216510.3390/molecules27072165Natural Small Molecules in Breast Cancer Treatment: Understandings from a Therapeutic ViewpointMd. Rezaul Islam0Fahadul Islam1Mohamed H. Nafady2Muniya Akter3Saikat Mitra4Rajib Das5Humaira Urmee6Sheikh Shohag7Aklima Akter8Kumarappan Chidambaram9Fahad A. Alhumaydhi10Talha Bin Emran11Simona Cavalu12Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka 1207, BangladeshDepartment of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka 1207, BangladeshFaculty of Applied Health Science Technology, Misr University for Science and Technology, Giza 12568, EgyptDepartment of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka 1207, BangladeshDepartment of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, BangladeshDepartment of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, BangladeshDepartment of Pharmaceutical Science, North South University, Dhaka 1229, BangladeshDepartment of Biochemistry and Molecular Biology, Faculty of Life Science, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj 8100, BangladeshDepartment of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka 1207, BangladeshDepartment of Pharmacology and Toxicology, College of Pharmacy, King Khalid University, Abha 62529, Saudi ArabiaDepartment of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah 52571, Saudi ArabiaDepartment of Pharmacy, BGC Trust University Bangladesh, Chittagong 4381, BangladeshFaculty of Medicine and Pharmacy, University of Oradea, 410087 Oradea, RomaniaBreast cancer (BrCa) is the most common malignancy in women and the second most significant cause of death from cancer. BrCa is one of the most challenging malignancies to treat, and it accounts for a large percentage of cancer-related deaths. The number of cases requiring more effective BrCa therapy has increased dramatically. Scientists are looking for more productive agents, such as organic combinations, for BrCa prevention and treatment because most chemotherapeutic agents are linked to cancer metastasis, the resistance of the drugs, and side effects. Natural compounds produced by living organisms promote apoptosis and inhibit metastasis, slowing the spread of cancer. As a result, these compounds may delay the spread of BrCa, enhancing survival rates and reducing the number of deaths caused by BrCa. Several natural compounds inhibit BrCa production while lowering cancer cell proliferation and triggering cell death. Natural compounds, in addition to therapeutic approaches, are efficient and potential agents for treating BrCa. This review highlights the natural compounds demonstrated in various studies to have anticancer properties in BrCa cells. Future research into biological anti-BrCa agents may pave the way for a new era in BrCa treatment, with natural anti-BrCa drugs playing a key role in improving BrCa patient survival rates.https://www.mdpi.com/1420-3049/27/7/2165natural compoundsantitumorimmune-suppressivebreast cancercombination therapy |
| spellingShingle | Md. Rezaul Islam Fahadul Islam Mohamed H. Nafady Muniya Akter Saikat Mitra Rajib Das Humaira Urmee Sheikh Shohag Aklima Akter Kumarappan Chidambaram Fahad A. Alhumaydhi Talha Bin Emran Simona Cavalu Natural Small Molecules in Breast Cancer Treatment: Understandings from a Therapeutic Viewpoint Molecules natural compounds antitumor immune-suppressive breast cancer combination therapy |
| title | Natural Small Molecules in Breast Cancer Treatment: Understandings from a Therapeutic Viewpoint |
| title_full | Natural Small Molecules in Breast Cancer Treatment: Understandings from a Therapeutic Viewpoint |
| title_fullStr | Natural Small Molecules in Breast Cancer Treatment: Understandings from a Therapeutic Viewpoint |
| title_full_unstemmed | Natural Small Molecules in Breast Cancer Treatment: Understandings from a Therapeutic Viewpoint |
| title_short | Natural Small Molecules in Breast Cancer Treatment: Understandings from a Therapeutic Viewpoint |
| title_sort | natural small molecules in breast cancer treatment understandings from a therapeutic viewpoint |
| topic | natural compounds antitumor immune-suppressive breast cancer combination therapy |
| url | https://www.mdpi.com/1420-3049/27/7/2165 |
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