Re-examining how complexin inhibits neurotransmitter release

Complexins play activating and inhibitory functions in neurotransmitter release. The complexin accessory helix inhibits release and was proposed to insert into SNARE complexes to prevent their full assembly. This model was supported by ‘superclamp’ and ‘poor-clamp’ mutations that enhanced or decreas...

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Bibliographic Details
Main Authors: Thorsten Trimbuch, Junjie Xu, David Flaherty, Diana R Tomchick, Josep Rizo, Christian Rosenmund
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-05-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/02391

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