Left atrial reverse remodeling improves risk stratification in patients with heart failure with recovered ejection fraction
Abstract We aimed to investigate the relationship between left atrial (LA) reverse remodeling and prognosis of heart failure (HF) with recovered ejection fraction (EF) (HFrecEF). Among 1,246 patients with acute heart failure enrolled in the prospective longitudinal follow-up study, 397 patients with...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-08630-1 |
| _version_ | 1818315685308137472 |
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| author | Masayuki Shiba Takao Kato Takeshi Morimoto Hidenori Yaku Yasutaka Inuzuka Yodo Tamaki Neiko Ozasa Yuta Seko Erika Yamamoto Yusuke Yoshikawa Takeshi Kitai Yugo Yamashita Moritake Iguchi Kazuya Nagao Yuichi Kawase Takashi Morinaga Mamoru Toyofuku Yutaka Furukawa Kenji Ando Kazushige Kadota Yukihito Sato Koichiro Kuwahara Takeshi Kimura |
| author_facet | Masayuki Shiba Takao Kato Takeshi Morimoto Hidenori Yaku Yasutaka Inuzuka Yodo Tamaki Neiko Ozasa Yuta Seko Erika Yamamoto Yusuke Yoshikawa Takeshi Kitai Yugo Yamashita Moritake Iguchi Kazuya Nagao Yuichi Kawase Takashi Morinaga Mamoru Toyofuku Yutaka Furukawa Kenji Ando Kazushige Kadota Yukihito Sato Koichiro Kuwahara Takeshi Kimura |
| author_sort | Masayuki Shiba |
| collection | DOAJ |
| description | Abstract We aimed to investigate the relationship between left atrial (LA) reverse remodeling and prognosis of heart failure (HF) with recovered ejection fraction (EF) (HFrecEF). Among 1,246 patients with acute heart failure enrolled in the prospective longitudinal follow-up study, 397 patients with HF with mildly-reduced EF and with reduced EF at discharge were analyzed. Echocardiography was performed during the index hospitalization and at the 6-month follow-up after discharge. They were divided into non-HFrecEF (n = 227) and HFrecEF (n = 170) groups. The primary outcome measure was a composite of all-cause death or hospitalization for HF. The cumulative 180-day incidence of the primary outcome measure after follow-up echocardiography was significantly lower in the HFrecEF group than in the non-HFrecEF group (8.9% versus 23.4%, log-rank P = 0.0002). LA reverse remodeling was associated with a lower cumulative 6-month incidence of the primary outcome measure in the HFrecEF group (4.7% versus 18.0%; HR: 0.27, 95%CI: 0.09–0.79, P = 0.01), but not in the non-HFrecEF group (24.4% versus 22.6%; HR: 1.13, 95%CI: 0.65–1.96, P = 0.28) with a significant LA reverse remodeling-by-HFrecEF interaction (P for interaction = 0.02). Combination of left ventricular and atrial reverse remodeling may help in improving HF risk stratification. |
| first_indexed | 2024-12-13T09:09:28Z |
| format | Article |
| id | doaj.art-ad4d24bfbf41442da3890d8c3b8d3287 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-13T09:09:28Z |
| publishDate | 2022-03-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj.art-ad4d24bfbf41442da3890d8c3b8d32872022-12-21T23:52:59ZengNature PortfolioScientific Reports2045-23222022-03-011211910.1038/s41598-022-08630-1Left atrial reverse remodeling improves risk stratification in patients with heart failure with recovered ejection fractionMasayuki Shiba0Takao Kato1Takeshi Morimoto2Hidenori Yaku3Yasutaka Inuzuka4Yodo Tamaki5Neiko Ozasa6Yuta Seko7Erika Yamamoto8Yusuke Yoshikawa9Takeshi Kitai10Yugo Yamashita11Moritake Iguchi12Kazuya Nagao13Yuichi Kawase14Takashi Morinaga15Mamoru Toyofuku16Yutaka Furukawa17Kenji Ando18Kazushige Kadota19Yukihito Sato20Koichiro Kuwahara21Takeshi Kimura22Department of Cardiovascular Medicine, Kyoto University Graduate School of MedicineDepartment of Cardiovascular Medicine, Kyoto University Graduate School of MedicineDepartment of Clinical Epidemiology, Hyogo College of MedicineDepartment of Cardiology, Mitsubishi Kyoto HospitalCardiovascular Medicine, Shiga General HospitalDivision of Cardiology, Tenri HospitalDepartment of Cardiovascular Medicine, Kyoto University Graduate School of MedicineDepartment of Cardiovascular Medicine, Kyoto University Graduate School of MedicineDepartment of Cardiovascular Medicine, Kyoto University Graduate School of MedicineDepartment of Cardiovascular Medicine, Kyoto University Graduate School of MedicineDivision of Heart Failure, National Cerebral and Cardiovascular CenterDepartment of Cardiovascular Medicine, Kyoto University Graduate School of MedicineDepartment of Cardiology, National Hospital Organization Kyoto Medical CenterDepartment of Cardiology, Osaka Red Cross HospitalDepartment of Cardiology, Kurashiki Central HospitalDepartment of Cardiology, Kokura Memorial HospitalDepartment of Cardiology, Japanese Red Cross Wakayama Medical CenterDepartment of Cardiovascular Medicine, Kobe City Medical Center General HospitalDepartment of Cardiology, Kokura Memorial HospitalDepartment of Cardiology, Kurashiki Central HospitalDepartment of Cardiology, Hyogo Prefectural Amagasaki General Medical CenterDepartment of Cardiovascular Medicine, Shinshu University Graduate School of MedicineDepartment of Cardiovascular Medicine, Kyoto University Graduate School of MedicineAbstract We aimed to investigate the relationship between left atrial (LA) reverse remodeling and prognosis of heart failure (HF) with recovered ejection fraction (EF) (HFrecEF). Among 1,246 patients with acute heart failure enrolled in the prospective longitudinal follow-up study, 397 patients with HF with mildly-reduced EF and with reduced EF at discharge were analyzed. Echocardiography was performed during the index hospitalization and at the 6-month follow-up after discharge. They were divided into non-HFrecEF (n = 227) and HFrecEF (n = 170) groups. The primary outcome measure was a composite of all-cause death or hospitalization for HF. The cumulative 180-day incidence of the primary outcome measure after follow-up echocardiography was significantly lower in the HFrecEF group than in the non-HFrecEF group (8.9% versus 23.4%, log-rank P = 0.0002). LA reverse remodeling was associated with a lower cumulative 6-month incidence of the primary outcome measure in the HFrecEF group (4.7% versus 18.0%; HR: 0.27, 95%CI: 0.09–0.79, P = 0.01), but not in the non-HFrecEF group (24.4% versus 22.6%; HR: 1.13, 95%CI: 0.65–1.96, P = 0.28) with a significant LA reverse remodeling-by-HFrecEF interaction (P for interaction = 0.02). Combination of left ventricular and atrial reverse remodeling may help in improving HF risk stratification.https://doi.org/10.1038/s41598-022-08630-1 |
| spellingShingle | Masayuki Shiba Takao Kato Takeshi Morimoto Hidenori Yaku Yasutaka Inuzuka Yodo Tamaki Neiko Ozasa Yuta Seko Erika Yamamoto Yusuke Yoshikawa Takeshi Kitai Yugo Yamashita Moritake Iguchi Kazuya Nagao Yuichi Kawase Takashi Morinaga Mamoru Toyofuku Yutaka Furukawa Kenji Ando Kazushige Kadota Yukihito Sato Koichiro Kuwahara Takeshi Kimura Left atrial reverse remodeling improves risk stratification in patients with heart failure with recovered ejection fraction Scientific Reports |
| title | Left atrial reverse remodeling improves risk stratification in patients with heart failure with recovered ejection fraction |
| title_full | Left atrial reverse remodeling improves risk stratification in patients with heart failure with recovered ejection fraction |
| title_fullStr | Left atrial reverse remodeling improves risk stratification in patients with heart failure with recovered ejection fraction |
| title_full_unstemmed | Left atrial reverse remodeling improves risk stratification in patients with heart failure with recovered ejection fraction |
| title_short | Left atrial reverse remodeling improves risk stratification in patients with heart failure with recovered ejection fraction |
| title_sort | left atrial reverse remodeling improves risk stratification in patients with heart failure with recovered ejection fraction |
| url | https://doi.org/10.1038/s41598-022-08630-1 |
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