Aberrant Cholesterol Metabolic Genes Regulation in a Negative Feedback Loop Induced by an Alphacoronavirus

Aberrant Cholesterol Metabolic Genes Regulation in a Negative Feedback Loop Induced by an Alphacoronavirus

Porcine epidemic diarrhea virus (PEDV) is an alphacoronavirus that causes acute inflammation and severe diarrhea in newborn piglets with a high mortality rate. Given that cholesterol is required for coronavirus infection in vitro, the role of endogenous cholesterol metabolism in regulating coronavir...

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Bibliographic Details
Main Authors: Hao-Yu Liu, Haotian Gu, Huan Qu, Wenbin Bao, Yanhua Li, Demin Cai
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Nutrition
Subjects:
cholesterol
SREBP2
FXR
epigenetic
PEDV
coronaviruses
Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2022.870680/full

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