Melatonin and Vitamins as Protectors against the Reproductive Toxicity of Bisphenols: Which Is the Most Effective? A Systematic Review and Meta-Analysis
Bisphenols such as bisphenol A (BPA), S (BPS), C (BPC), F (BPF), AF (BPAF), tetrabromobisphenol, nonylphenol, and octylphenol are plasticizers used worldwide to manufacture daily-use articles. Exposure to these compounds is related to many pathologies of public health importance, such as infertility...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/19/14930 |
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| author | Sheila I. Peña-Corona Juan I. Chávez-Corona Luis E. Pérez-Caltzontzin Dinorah Vargas-Estrada C. Adriana Mendoza-Rodríguez Edgar Ramos-Martínez Jose L. Cerbón-Gutiérrez José A. Herrera-Barragán David Quintanar-Guerrero Gerardo Leyva-Gómez |
| author_facet | Sheila I. Peña-Corona Juan I. Chávez-Corona Luis E. Pérez-Caltzontzin Dinorah Vargas-Estrada C. Adriana Mendoza-Rodríguez Edgar Ramos-Martínez Jose L. Cerbón-Gutiérrez José A. Herrera-Barragán David Quintanar-Guerrero Gerardo Leyva-Gómez |
| author_sort | Sheila I. Peña-Corona |
| collection | DOAJ |
| description | Bisphenols such as bisphenol A (BPA), S (BPS), C (BPC), F (BPF), AF (BPAF), tetrabromobisphenol, nonylphenol, and octylphenol are plasticizers used worldwide to manufacture daily-use articles. Exposure to these compounds is related to many pathologies of public health importance, such as infertility. Using a protector compound against the reproductive toxicological effects of bisphenols is of scientific interest. Melatonin and vitamins have been tested, but the results are not conclusive. To this end, this systematic review and meta-analysis compared the response of reproductive variables to melatonin and vitamin administration as protectors against damage caused by bisphenols. We search for controlled studies of male rats exposed to bisphenols to induce alterations in reproduction, with at least one intervention group receiving melatonin or vitamins (B, C, or E). Also, molecular docking simulations were performed between the androgen (AR) and estrogen receptors (ER), melatonin, and vitamins. About 1234 records were initially found; finally, 13 studies were qualified for review and meta-analysis. Melatonin plus bisphenol improves sperm concentration and viability of sperm and increases testosterone serum levels compared with control groups; however, groups receiving vitamins plus bisphenols had lower sperm concentration, total testis weight, and testosterone serum levels than the control. In the docking analysis, vitamin E had the highest negative MolDock score, representing the best binding affinity with AR and ER, compared with other vitamins and melatonin in the docking. Our findings suggest that vitamins could act as an endocrine disruptor, and melatonin is most effective in protecting against the toxic effects of bisphenols. |
| first_indexed | 2024-03-10T21:43:00Z |
| format | Article |
| id | doaj.art-ad4e3a11df7e448081495f9cad9db90f |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T21:43:00Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ad4e3a11df7e448081495f9cad9db90f2023-11-19T14:32:44ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-10-0124191493010.3390/ijms241914930Melatonin and Vitamins as Protectors against the Reproductive Toxicity of Bisphenols: Which Is the Most Effective? A Systematic Review and Meta-AnalysisSheila I. Peña-Corona0Juan I. Chávez-Corona1Luis E. Pérez-Caltzontzin2Dinorah Vargas-Estrada3C. Adriana Mendoza-Rodríguez4Edgar Ramos-Martínez5Jose L. Cerbón-Gutiérrez6José A. Herrera-Barragán7David Quintanar-Guerrero8Gerardo Leyva-Gómez9Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México 04510, MexicoLaboratorio de Investigación y Posgrado en Tecnología Farmacéutica, Universidad Nacional Autónoma de México-FESC, Campus 1, Cuautitlán Izcalli 54714, MexicoDepartamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México 04510, MexicoDepartamento de Fisiología y Farmacología, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Ciudad de México 04510, MexicoDepartamento de Biología, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México 04510, MexicoDepartamento de Biología, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México 04510, MexicoDepartamento de Reproducción, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Ciudad de México 04510, MexicoDepartamento de Producción Agricola y Animal, Universidad Autónoma Metropolitana Unidad Xochimilco, Ciudad de México 04960, MexicoLaboratorio de Investigación y Posgrado en Tecnología Farmacéutica, Universidad Nacional Autónoma de México-FESC, Campus 1, Cuautitlán Izcalli 54714, MexicoDepartamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México 04510, MexicoBisphenols such as bisphenol A (BPA), S (BPS), C (BPC), F (BPF), AF (BPAF), tetrabromobisphenol, nonylphenol, and octylphenol are plasticizers used worldwide to manufacture daily-use articles. Exposure to these compounds is related to many pathologies of public health importance, such as infertility. Using a protector compound against the reproductive toxicological effects of bisphenols is of scientific interest. Melatonin and vitamins have been tested, but the results are not conclusive. To this end, this systematic review and meta-analysis compared the response of reproductive variables to melatonin and vitamin administration as protectors against damage caused by bisphenols. We search for controlled studies of male rats exposed to bisphenols to induce alterations in reproduction, with at least one intervention group receiving melatonin or vitamins (B, C, or E). Also, molecular docking simulations were performed between the androgen (AR) and estrogen receptors (ER), melatonin, and vitamins. About 1234 records were initially found; finally, 13 studies were qualified for review and meta-analysis. Melatonin plus bisphenol improves sperm concentration and viability of sperm and increases testosterone serum levels compared with control groups; however, groups receiving vitamins plus bisphenols had lower sperm concentration, total testis weight, and testosterone serum levels than the control. In the docking analysis, vitamin E had the highest negative MolDock score, representing the best binding affinity with AR and ER, compared with other vitamins and melatonin in the docking. Our findings suggest that vitamins could act as an endocrine disruptor, and melatonin is most effective in protecting against the toxic effects of bisphenols.https://www.mdpi.com/1422-0067/24/19/14930hormone receptorsendocrine disruptorsreproductionmolecular dockingsperm |
| spellingShingle | Sheila I. Peña-Corona Juan I. Chávez-Corona Luis E. Pérez-Caltzontzin Dinorah Vargas-Estrada C. Adriana Mendoza-Rodríguez Edgar Ramos-Martínez Jose L. Cerbón-Gutiérrez José A. Herrera-Barragán David Quintanar-Guerrero Gerardo Leyva-Gómez Melatonin and Vitamins as Protectors against the Reproductive Toxicity of Bisphenols: Which Is the Most Effective? A Systematic Review and Meta-Analysis International Journal of Molecular Sciences hormone receptors endocrine disruptors reproduction molecular docking sperm |
| title | Melatonin and Vitamins as Protectors against the Reproductive Toxicity of Bisphenols: Which Is the Most Effective? A Systematic Review and Meta-Analysis |
| title_full | Melatonin and Vitamins as Protectors against the Reproductive Toxicity of Bisphenols: Which Is the Most Effective? A Systematic Review and Meta-Analysis |
| title_fullStr | Melatonin and Vitamins as Protectors against the Reproductive Toxicity of Bisphenols: Which Is the Most Effective? A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Melatonin and Vitamins as Protectors against the Reproductive Toxicity of Bisphenols: Which Is the Most Effective? A Systematic Review and Meta-Analysis |
| title_short | Melatonin and Vitamins as Protectors against the Reproductive Toxicity of Bisphenols: Which Is the Most Effective? A Systematic Review and Meta-Analysis |
| title_sort | melatonin and vitamins as protectors against the reproductive toxicity of bisphenols which is the most effective a systematic review and meta analysis |
| topic | hormone receptors endocrine disruptors reproduction molecular docking sperm |
| url | https://www.mdpi.com/1422-0067/24/19/14930 |
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