The more critical murderer of atherosclerosis than lipid metabolism: chronic stress
Abstract Background The mortality of atherosclerotic cerebrovascular disease is on the rise, and changes in intimal and media thickness are a leading cause of cerebral ischemia-related death. Levels of low density lipoprotein cholesterol (LDLC), total cholesterol (TC), and chronic stress (CS) are al...
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| Format: | Article |
| Language: | English |
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BMC
2018-06-01
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| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12944-018-0795-4 |
| _version_ | 1819263456666189824 |
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| author | Ling-bing Meng Ruomei Qi Lei Xu Yuhui Chen Zemou Yu Peng Guo Tao Gong |
| author_facet | Ling-bing Meng Ruomei Qi Lei Xu Yuhui Chen Zemou Yu Peng Guo Tao Gong |
| author_sort | Ling-bing Meng |
| collection | DOAJ |
| description | Abstract Background The mortality of atherosclerotic cerebrovascular disease is on the rise, and changes in intimal and media thickness are a leading cause of cerebral ischemia-related death. Levels of low density lipoprotein cholesterol (LDLC), total cholesterol (TC), and chronic stress (CS) are all recognized risk factors for atherosclerosis (AS). However, the leading independent risk factor is indistinct. This study explored the effects of chronic stress, LDLC, and TC on AS and intimal and media thickness, preliminarily explored the main risk factor of AS, and analyzed the related histocyte mechanisms for macrophages and endothelial cells. Methods Conditions include normal, high-fat diet (HF), and HF plus CS. The correlations between intimal and media thickness and general risk factors were analyzed using χ2, Spearman’s rho test, and multiple linear regression. Univariate Cox regression was used to identify potential factors that affect the non-depression time (NDT). We performed a ROC curve to determine the ability of this condition to predict the thickness. Immunohistochemistry was implemented to detect macrophagocytes and endotheliocytes. Results Based on χ2 and Spearman’s rho test, LDLC, TC, and CS are all related with intimal and media thickness (P < 0.05). However, in multiple linear regression, CS is still a risk factor of thickness (P < 0.05) but LDLC and TC are not. High levels of LDLC, TC, and CS were correlated with poor NDT (P < 0.05). This condition can predict the thickness sensitively. The endarterium is richest in macrophagocytes, and the arrangement of endotheliocytes is disordered and cracked under CS. Conclusion CS is the main independent risk factor for AS and intimal (and media) thickness, rather than LDLC or TC. |
| first_indexed | 2024-12-23T20:13:53Z |
| format | Article |
| id | doaj.art-ad50a27d63e248df99b3d4c03cc93cd3 |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-12-23T20:13:53Z |
| publishDate | 2018-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-ad50a27d63e248df99b3d4c03cc93cd32022-12-21T17:32:45ZengBMCLipids in Health and Disease1476-511X2018-06-011711910.1186/s12944-018-0795-4The more critical murderer of atherosclerosis than lipid metabolism: chronic stressLing-bing Meng0Ruomei Qi1Lei Xu2Yuhui Chen3Zemou Yu4Peng Guo5Tao Gong6Neurology Department, Beijing Hospital, National Center of GerontologyThe MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of GerontologyNeurology Department, Beijing Hospital, National Center of GerontologyNeurology Department, Beijing Hospital, National Center of GerontologyDepartment of Neurology, Peking University First HospitalDepartment of Orthopedics, The Fourth Hospital of Hebei Medical UniversityNeurology Department, Beijing Hospital, National Center of GerontologyAbstract Background The mortality of atherosclerotic cerebrovascular disease is on the rise, and changes in intimal and media thickness are a leading cause of cerebral ischemia-related death. Levels of low density lipoprotein cholesterol (LDLC), total cholesterol (TC), and chronic stress (CS) are all recognized risk factors for atherosclerosis (AS). However, the leading independent risk factor is indistinct. This study explored the effects of chronic stress, LDLC, and TC on AS and intimal and media thickness, preliminarily explored the main risk factor of AS, and analyzed the related histocyte mechanisms for macrophages and endothelial cells. Methods Conditions include normal, high-fat diet (HF), and HF plus CS. The correlations between intimal and media thickness and general risk factors were analyzed using χ2, Spearman’s rho test, and multiple linear regression. Univariate Cox regression was used to identify potential factors that affect the non-depression time (NDT). We performed a ROC curve to determine the ability of this condition to predict the thickness. Immunohistochemistry was implemented to detect macrophagocytes and endotheliocytes. Results Based on χ2 and Spearman’s rho test, LDLC, TC, and CS are all related with intimal and media thickness (P < 0.05). However, in multiple linear regression, CS is still a risk factor of thickness (P < 0.05) but LDLC and TC are not. High levels of LDLC, TC, and CS were correlated with poor NDT (P < 0.05). This condition can predict the thickness sensitively. The endarterium is richest in macrophagocytes, and the arrangement of endotheliocytes is disordered and cracked under CS. Conclusion CS is the main independent risk factor for AS and intimal (and media) thickness, rather than LDLC or TC.http://link.springer.com/article/10.1186/s12944-018-0795-4Cerebrovascular diseaseAtherosclerosisVascular intimal thicknessVascular media thicknessChronic stressLow density lipoprotein cholesterol |
| spellingShingle | Ling-bing Meng Ruomei Qi Lei Xu Yuhui Chen Zemou Yu Peng Guo Tao Gong The more critical murderer of atherosclerosis than lipid metabolism: chronic stress Lipids in Health and Disease Cerebrovascular disease Atherosclerosis Vascular intimal thickness Vascular media thickness Chronic stress Low density lipoprotein cholesterol |
| title | The more critical murderer of atherosclerosis than lipid metabolism: chronic stress |
| title_full | The more critical murderer of atherosclerosis than lipid metabolism: chronic stress |
| title_fullStr | The more critical murderer of atherosclerosis than lipid metabolism: chronic stress |
| title_full_unstemmed | The more critical murderer of atherosclerosis than lipid metabolism: chronic stress |
| title_short | The more critical murderer of atherosclerosis than lipid metabolism: chronic stress |
| title_sort | more critical murderer of atherosclerosis than lipid metabolism chronic stress |
| topic | Cerebrovascular disease Atherosclerosis Vascular intimal thickness Vascular media thickness Chronic stress Low density lipoprotein cholesterol |
| url | http://link.springer.com/article/10.1186/s12944-018-0795-4 |
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