Knockout of ACE-N facilitates improved cardiac function after myocardial infarction

Knockout of ACE-N facilitates improved cardiac function after myocardial infarction

Angiotensin-converting enzyme (ACE) hydrolyzes N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) into inactive fragments through its N-terminal site (ACEN). We previously showed that Ac-SDKP mediates ACE inhibitors' cardiac effects. Whether increased bioavailability of endogenous Ac-SDKP caused...

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Bibliographic Details
Main Authors: Hamid Suhail, Hongmei Peng, Jiang Xu, Hani N. Sabbah, Khalid Matrougui, Tang-Dong Liao, Pablo A. Ortiz, Kenneth E. Bernstein, Nour-Eddine Rhaleb
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Journal of Molecular and Cellular Cardiology Plus
Subjects:
Ac-SDKP
ACE-N
Myocardial infarction
SERCA2
Fibrosis
Cardiac function
Online Access:http://www.sciencedirect.com/science/article/pii/S2772976122000186

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