The Diverse Pathogenicity of Various <i>Babesia</i> Parasite Species That Infect Dogs
<i>Babesia</i> species infect a very wide range of mammal hosts across the globe, and zoonotic infections are of growing concern. Several species of the <i>Babesia</i> genus infect dogs, and some of these cause significant morbidity and mortality. The Apicomplexan parasite re...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/12/12/1437 |
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| author | Andrew L. Leisewitz Vladimir Mrljak Jonathan D. Dear Adam Birkenheuer |
| author_facet | Andrew L. Leisewitz Vladimir Mrljak Jonathan D. Dear Adam Birkenheuer |
| author_sort | Andrew L. Leisewitz |
| collection | DOAJ |
| description | <i>Babesia</i> species infect a very wide range of mammal hosts across the globe, and zoonotic infections are of growing concern. Several species of the <i>Babesia</i> genus infect dogs, and some of these cause significant morbidity and mortality. The Apicomplexan parasite resides within the red cell and infections result in direct damage to the host through intra- and extravascular hemolysis. An exuberant inflammatory response by the host to some species of <i>Babesia</i> parasites also results in significant collateral damage to the host. Canine infections have been the subject of many studies as the well-being of these companion animals is increasingly threatened by the spread of tick vectors and an increasingly mobile dog population. There are currently no widely available and effective vaccines, and effective treatment can be challenging. Understanding disease pathogenesis underlies the development of new treatments. The varying pathogenicity of the various <i>Babesia</i> parasite species that infect dogs offers an opportunity to explore the molecular basis for the wide range of diseases caused by infection with this parasite genus. In this review, we focus on what has been reported about the clinical presentation of <i>Babesia</i>-infected dogs in an attempt to compare the severity of disease caused by different <i>Babesia</i> species. |
| first_indexed | 2024-03-08T20:27:15Z |
| format | Article |
| id | doaj.art-ad531e45fe1147b7a7432c462a9ecd25 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-08T20:27:15Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-ad531e45fe1147b7a7432c462a9ecd252023-12-22T14:30:59ZengMDPI AGPathogens2076-08172023-12-011212143710.3390/pathogens12121437The Diverse Pathogenicity of Various <i>Babesia</i> Parasite Species That Infect DogsAndrew L. Leisewitz0Vladimir Mrljak1Jonathan D. Dear2Adam Birkenheuer3Companion Animal Clinical Studies, Faculty of Veterinary Science, University of Pretoria, Pretoria 0110, South AfricaClinic for Internal Diseases, Faculty of Veterinary Medicine, University of Zagreb, 10000 Zagreb, CroatiaDepartment of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USADepartment of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA<i>Babesia</i> species infect a very wide range of mammal hosts across the globe, and zoonotic infections are of growing concern. Several species of the <i>Babesia</i> genus infect dogs, and some of these cause significant morbidity and mortality. The Apicomplexan parasite resides within the red cell and infections result in direct damage to the host through intra- and extravascular hemolysis. An exuberant inflammatory response by the host to some species of <i>Babesia</i> parasites also results in significant collateral damage to the host. Canine infections have been the subject of many studies as the well-being of these companion animals is increasingly threatened by the spread of tick vectors and an increasingly mobile dog population. There are currently no widely available and effective vaccines, and effective treatment can be challenging. Understanding disease pathogenesis underlies the development of new treatments. The varying pathogenicity of the various <i>Babesia</i> parasite species that infect dogs offers an opportunity to explore the molecular basis for the wide range of diseases caused by infection with this parasite genus. In this review, we focus on what has been reported about the clinical presentation of <i>Babesia</i>-infected dogs in an attempt to compare the severity of disease caused by different <i>Babesia</i> species.https://www.mdpi.com/2076-0817/12/12/1437babesiosiscanine<i>Babesia rossi</i><i>Babesia canis</i><i>Babesia gibsoni</i><i>Babesia vogeli</i> |
| spellingShingle | Andrew L. Leisewitz Vladimir Mrljak Jonathan D. Dear Adam Birkenheuer The Diverse Pathogenicity of Various <i>Babesia</i> Parasite Species That Infect Dogs Pathogens babesiosis canine <i>Babesia rossi</i> <i>Babesia canis</i> <i>Babesia gibsoni</i> <i>Babesia vogeli</i> |
| title | The Diverse Pathogenicity of Various <i>Babesia</i> Parasite Species That Infect Dogs |
| title_full | The Diverse Pathogenicity of Various <i>Babesia</i> Parasite Species That Infect Dogs |
| title_fullStr | The Diverse Pathogenicity of Various <i>Babesia</i> Parasite Species That Infect Dogs |
| title_full_unstemmed | The Diverse Pathogenicity of Various <i>Babesia</i> Parasite Species That Infect Dogs |
| title_short | The Diverse Pathogenicity of Various <i>Babesia</i> Parasite Species That Infect Dogs |
| title_sort | diverse pathogenicity of various i babesia i parasite species that infect dogs |
| topic | babesiosis canine <i>Babesia rossi</i> <i>Babesia canis</i> <i>Babesia gibsoni</i> <i>Babesia vogeli</i> |
| url | https://www.mdpi.com/2076-0817/12/12/1437 |
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