Role of Endoplasmic Reticulum Stress in The Male Reproductive System
Testicular dysfunction, whether linked to varicocele, obesity, diabetes, aging, inflammation, or lifestyle or environmentalissues, is frequently accompanied by an accumulation of unfolded or misfolded proteins, indicating impaired endoplasmicreticulum (ER) function. In this review, we examined the G...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Royan Institute (ACECR), Tehran
2023-07-01
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| Series: | Cell Journal |
| Subjects: | |
| Online Access: | https://www.celljournal.org/article_705364_6a455e74f693a0893661036c574e1e47.pdf |
| _version_ | 1797752853734883328 |
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| author | Mohsen Rahmani Marziyeh Tavalaee Joel R Drevet Mohammad Hossein Nasr-Esfahani |
| author_facet | Mohsen Rahmani Marziyeh Tavalaee Joel R Drevet Mohammad Hossein Nasr-Esfahani |
| author_sort | Mohsen Rahmani |
| collection | DOAJ |
| description | Testicular dysfunction, whether linked to varicocele, obesity, diabetes, aging, inflammation, or lifestyle or environmentalissues, is frequently accompanied by an accumulation of unfolded or misfolded proteins, indicating impaired endoplasmicreticulum (ER) function. In this review, we examined the Google Scholar, Scopus and PubMed databases (from 2011to 2022) to support the association of ER stress with defective spermatogenesis in animal models and humans. ERstress, whether in its pro-survival or pro-apoptotic aspect, appears to be closely linked to each studied situation.Several studies have demonstrated a significant increase in oxidative stress (OS) levels in infertile men compared tofertile individuals, which is associated with poor spermatogenesis quality. OS is likely the result of the interplay betweenER stress and spermatogenesis defects. These findings suggest that therapeutic strategies aimed at mitigating bothER stress and OS could be of interest in restoring male reproductive function. |
| first_indexed | 2024-03-12T17:10:31Z |
| format | Article |
| id | doaj.art-ad5328eababb45709f36dee0cbb00332 |
| institution | Directory Open Access Journal |
| issn | 2228-5806 2228-5814 |
| language | English |
| last_indexed | 2024-03-12T17:10:31Z |
| publishDate | 2023-07-01 |
| publisher | Royan Institute (ACECR), Tehran |
| record_format | Article |
| series | Cell Journal |
| spelling | doaj.art-ad5328eababb45709f36dee0cbb003322023-08-06T10:58:43ZengRoyan Institute (ACECR), TehranCell Journal2228-58062228-58142023-07-0125743744610.22074/cellj.2023.1983074.1205705364Role of Endoplasmic Reticulum Stress in The Male Reproductive SystemMohsen Rahmani0Marziyeh Tavalaee1Joel R Drevet2Mohammad Hossein Nasr-Esfahani3Department of Animal Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, IranDepartment of Animal Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, IranGReD Institute, INSERM-CNRS-Université Clermont Auvergne, Faculty of Medicine, CRBC, Clermont-Ferrand, FranceDepartment of Animal Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, IranTesticular dysfunction, whether linked to varicocele, obesity, diabetes, aging, inflammation, or lifestyle or environmentalissues, is frequently accompanied by an accumulation of unfolded or misfolded proteins, indicating impaired endoplasmicreticulum (ER) function. In this review, we examined the Google Scholar, Scopus and PubMed databases (from 2011to 2022) to support the association of ER stress with defective spermatogenesis in animal models and humans. ERstress, whether in its pro-survival or pro-apoptotic aspect, appears to be closely linked to each studied situation.Several studies have demonstrated a significant increase in oxidative stress (OS) levels in infertile men compared tofertile individuals, which is associated with poor spermatogenesis quality. OS is likely the result of the interplay betweenER stress and spermatogenesis defects. These findings suggest that therapeutic strategies aimed at mitigating bothER stress and OS could be of interest in restoring male reproductive function.https://www.celljournal.org/article_705364_6a455e74f693a0893661036c574e1e47.pdfapoptosisendoplasmic reticulum stressspermatogenesisvaricocele |
| spellingShingle | Mohsen Rahmani Marziyeh Tavalaee Joel R Drevet Mohammad Hossein Nasr-Esfahani Role of Endoplasmic Reticulum Stress in The Male Reproductive System Cell Journal apoptosis endoplasmic reticulum stress spermatogenesis varicocele |
| title | Role of Endoplasmic Reticulum Stress in The Male Reproductive System |
| title_full | Role of Endoplasmic Reticulum Stress in The Male Reproductive System |
| title_fullStr | Role of Endoplasmic Reticulum Stress in The Male Reproductive System |
| title_full_unstemmed | Role of Endoplasmic Reticulum Stress in The Male Reproductive System |
| title_short | Role of Endoplasmic Reticulum Stress in The Male Reproductive System |
| title_sort | role of endoplasmic reticulum stress in the male reproductive system |
| topic | apoptosis endoplasmic reticulum stress spermatogenesis varicocele |
| url | https://www.celljournal.org/article_705364_6a455e74f693a0893661036c574e1e47.pdf |
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