Effects of Dopamine on stem cells and its potential roles in the treatment of inflammatory disorders: a narrative review
Abstract Inflammation is the host's protective response against harmful external stimulation that helps tissue repair and remodeling. However, excessive inflammation seriously threatens the patient's life. Due to anti-inflammatory effects, corticosteroids, immunosuppressants, and monoclona...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | Stem Cell Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13287-023-03454-w |
| _version_ | 1797453703476674560 |
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| author | Guan-qiao Liu Zi-xian Liu Ze-xin Lin Peng Chen Yu-chi Yan Qing-rong Lin Yan-jun Hu Nan Jiang Bin Yu |
| author_facet | Guan-qiao Liu Zi-xian Liu Ze-xin Lin Peng Chen Yu-chi Yan Qing-rong Lin Yan-jun Hu Nan Jiang Bin Yu |
| author_sort | Guan-qiao Liu |
| collection | DOAJ |
| description | Abstract Inflammation is the host's protective response against harmful external stimulation that helps tissue repair and remodeling. However, excessive inflammation seriously threatens the patient's life. Due to anti-inflammatory effects, corticosteroids, immunosuppressants, and monoclonal antibodies are used to treat various inflammatory diseases, but drug resistance, non-responsiveness, and severe side effect limit their development and application. Therefore, developing other alternative therapies has become essential in anti-inflammatory therapy. In recent years, the in-depth study of stem cells has made them a promising alternative drug for the treatment of inflammatory diseases, and the function of stem cells is regulated by a variety of signals, of which dopamine signaling is one of the main influencing factors. In this review, we review the effects of dopamine on various adult stem cells (neural stem cells, mesenchymal stromal cells, hematopoietic stem cells, and cancer stem cells) and their signaling pathways, as well as the application of some critical dopamine receptor agonists/antagonists. Besides, we also review the role of various adult stem cells in inflammatory diseases and discuss the potential anti-inflammation function of dopamine receptors, which provides a new therapeutic target for regenerative medicine in inflammatory diseases. |
| first_indexed | 2024-03-09T15:26:34Z |
| format | Article |
| id | doaj.art-ad538d56c77c4465a88f2c3a476ed5ec |
| institution | Directory Open Access Journal |
| issn | 1757-6512 |
| language | English |
| last_indexed | 2024-03-09T15:26:34Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj.art-ad538d56c77c4465a88f2c3a476ed5ec2023-11-26T12:31:08ZengBMCStem Cell Research & Therapy1757-65122023-08-0114111310.1186/s13287-023-03454-wEffects of Dopamine on stem cells and its potential roles in the treatment of inflammatory disorders: a narrative reviewGuan-qiao Liu0Zi-xian Liu1Ze-xin Lin2Peng Chen3Yu-chi Yan4Qing-rong Lin5Yan-jun Hu6Nan Jiang7Bin Yu8Division of Orthopaedics & Traumatology, Department of Orthopaedics, Southern Medical University Nanfang HospitalDivision of Orthopaedics & Traumatology, Department of Orthopaedics, Southern Medical University Nanfang HospitalDivision of Orthopaedics & Traumatology, Department of Orthopaedics, Southern Medical University Nanfang HospitalDivision of Orthopaedics & Traumatology, Department of Orthopaedics, Southern Medical University Nanfang HospitalDivision of Orthopaedics & Traumatology, Department of Orthopaedics, Southern Medical University Nanfang HospitalDivision of Orthopaedics & Traumatology, Department of Orthopaedics, Southern Medical University Nanfang HospitalDivision of Orthopaedics & Traumatology, Department of Orthopaedics, Southern Medical University Nanfang HospitalDivision of Orthopaedics & Traumatology, Department of Orthopaedics, Southern Medical University Nanfang HospitalDivision of Orthopaedics & Traumatology, Department of Orthopaedics, Southern Medical University Nanfang HospitalAbstract Inflammation is the host's protective response against harmful external stimulation that helps tissue repair and remodeling. However, excessive inflammation seriously threatens the patient's life. Due to anti-inflammatory effects, corticosteroids, immunosuppressants, and monoclonal antibodies are used to treat various inflammatory diseases, but drug resistance, non-responsiveness, and severe side effect limit their development and application. Therefore, developing other alternative therapies has become essential in anti-inflammatory therapy. In recent years, the in-depth study of stem cells has made them a promising alternative drug for the treatment of inflammatory diseases, and the function of stem cells is regulated by a variety of signals, of which dopamine signaling is one of the main influencing factors. In this review, we review the effects of dopamine on various adult stem cells (neural stem cells, mesenchymal stromal cells, hematopoietic stem cells, and cancer stem cells) and their signaling pathways, as well as the application of some critical dopamine receptor agonists/antagonists. Besides, we also review the role of various adult stem cells in inflammatory diseases and discuss the potential anti-inflammation function of dopamine receptors, which provides a new therapeutic target for regenerative medicine in inflammatory diseases.https://doi.org/10.1186/s13287-023-03454-wDopamineNeuron stem cellMesenchymal stromal cellHematopoietic stem cellCancer stem cellInflammatory disorders |
| spellingShingle | Guan-qiao Liu Zi-xian Liu Ze-xin Lin Peng Chen Yu-chi Yan Qing-rong Lin Yan-jun Hu Nan Jiang Bin Yu Effects of Dopamine on stem cells and its potential roles in the treatment of inflammatory disorders: a narrative review Stem Cell Research & Therapy Dopamine Neuron stem cell Mesenchymal stromal cell Hematopoietic stem cell Cancer stem cell Inflammatory disorders |
| title | Effects of Dopamine on stem cells and its potential roles in the treatment of inflammatory disorders: a narrative review |
| title_full | Effects of Dopamine on stem cells and its potential roles in the treatment of inflammatory disorders: a narrative review |
| title_fullStr | Effects of Dopamine on stem cells and its potential roles in the treatment of inflammatory disorders: a narrative review |
| title_full_unstemmed | Effects of Dopamine on stem cells and its potential roles in the treatment of inflammatory disorders: a narrative review |
| title_short | Effects of Dopamine on stem cells and its potential roles in the treatment of inflammatory disorders: a narrative review |
| title_sort | effects of dopamine on stem cells and its potential roles in the treatment of inflammatory disorders a narrative review |
| topic | Dopamine Neuron stem cell Mesenchymal stromal cell Hematopoietic stem cell Cancer stem cell Inflammatory disorders |
| url | https://doi.org/10.1186/s13287-023-03454-w |
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