The Impact of Estrogen Receptor in Arterial and Lymphatic Vascular Diseases
The lower incidence of cardiovascular diseases in pre-menopausal women compared to men is well-known documented. This protection has been largely attributed to the protective effect of estrogens, which exert many beneficial effects against arterial diseases, including vasodilatation, acceleration of...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-05-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/21/9/3244 |
| _version_ | 1797568921715343360 |
|---|---|
| author | Coralie Fontaine Florent Morfoisse Florence Tatin Audrey Zamora Rana Zahreddine Daniel Henrion Jean-François Arnal Françoise Lenfant Barbara Garmy-Susini |
| author_facet | Coralie Fontaine Florent Morfoisse Florence Tatin Audrey Zamora Rana Zahreddine Daniel Henrion Jean-François Arnal Françoise Lenfant Barbara Garmy-Susini |
| author_sort | Coralie Fontaine |
| collection | DOAJ |
| description | The lower incidence of cardiovascular diseases in pre-menopausal women compared to men is well-known documented. This protection has been largely attributed to the protective effect of estrogens, which exert many beneficial effects against arterial diseases, including vasodilatation, acceleration of healing in response to arterial injury, arterial collateral growth and atheroprotection. More recently, with the visualization of the lymphatic vessels, the impact of estrogens on lymphedema and lymphatic diseases started to be elucidated. These estrogenic effects are mediated not only by the classic nuclear/genomic actions via the specific estrogen receptor (ER) α and β, but also by rapid extra-nuclear membrane-initiated steroid signaling (MISS). The ERs are expressed by endothelial, lymphatic and smooth muscle cells in the different vessels. In this review, we will summarize the complex vascular effects of estrogens and selective estrogen receptor modulators (SERMs) that have been described using different transgenic mouse models with selective loss of ERα function and numerous animal models of vascular and lymphatic diseases. |
| first_indexed | 2024-03-10T20:03:48Z |
| format | Article |
| id | doaj.art-ad55c975fe74421eb8353b6740142dec |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T20:03:48Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ad55c975fe74421eb8353b6740142dec2023-11-19T23:26:40ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-05-01219324410.3390/ijms21093244The Impact of Estrogen Receptor in Arterial and Lymphatic Vascular DiseasesCoralie Fontaine0Florent Morfoisse1Florence Tatin2Audrey Zamora3Rana Zahreddine4Daniel Henrion5Jean-François Arnal6Françoise Lenfant7Barbara Garmy-Susini8INSERM-UPS UMR U1048, Institut des Maladies Métaboliques et Cardiovasculaires, Université de Toulouse, BP 84225, 31 432 Toulouse cedex 04, FranceINSERM-UPS UMR U1048, Institut des Maladies Métaboliques et Cardiovasculaires, Université de Toulouse, BP 84225, 31 432 Toulouse cedex 04, FranceINSERM-UPS UMR U1048, Institut des Maladies Métaboliques et Cardiovasculaires, Université de Toulouse, BP 84225, 31 432 Toulouse cedex 04, FranceINSERM-UPS UMR U1048, Institut des Maladies Métaboliques et Cardiovasculaires, Université de Toulouse, BP 84225, 31 432 Toulouse cedex 04, FranceINSERM-UPS UMR U1048, Institut des Maladies Métaboliques et Cardiovasculaires, Université de Toulouse, BP 84225, 31 432 Toulouse cedex 04, FranceINSERM U1083 CNRS UMR 6015, CHU, MITOVASC Institute and CARFI Facility, Université d’Angers, 49933 ANGERS Cedex 09, FranceINSERM-UPS UMR U1048, Institut des Maladies Métaboliques et Cardiovasculaires, Université de Toulouse, BP 84225, 31 432 Toulouse cedex 04, FranceINSERM-UPS UMR U1048, Institut des Maladies Métaboliques et Cardiovasculaires, Université de Toulouse, BP 84225, 31 432 Toulouse cedex 04, FranceINSERM-UPS UMR U1048, Institut des Maladies Métaboliques et Cardiovasculaires, Université de Toulouse, BP 84225, 31 432 Toulouse cedex 04, FranceThe lower incidence of cardiovascular diseases in pre-menopausal women compared to men is well-known documented. This protection has been largely attributed to the protective effect of estrogens, which exert many beneficial effects against arterial diseases, including vasodilatation, acceleration of healing in response to arterial injury, arterial collateral growth and atheroprotection. More recently, with the visualization of the lymphatic vessels, the impact of estrogens on lymphedema and lymphatic diseases started to be elucidated. These estrogenic effects are mediated not only by the classic nuclear/genomic actions via the specific estrogen receptor (ER) α and β, but also by rapid extra-nuclear membrane-initiated steroid signaling (MISS). The ERs are expressed by endothelial, lymphatic and smooth muscle cells in the different vessels. In this review, we will summarize the complex vascular effects of estrogens and selective estrogen receptor modulators (SERMs) that have been described using different transgenic mouse models with selective loss of ERα function and numerous animal models of vascular and lymphatic diseases.https://www.mdpi.com/1422-0067/21/9/3244estrogensERαendothelial cellsarteriallymphatic |
| spellingShingle | Coralie Fontaine Florent Morfoisse Florence Tatin Audrey Zamora Rana Zahreddine Daniel Henrion Jean-François Arnal Françoise Lenfant Barbara Garmy-Susini The Impact of Estrogen Receptor in Arterial and Lymphatic Vascular Diseases International Journal of Molecular Sciences estrogens ERα endothelial cells arterial lymphatic |
| title | The Impact of Estrogen Receptor in Arterial and Lymphatic Vascular Diseases |
| title_full | The Impact of Estrogen Receptor in Arterial and Lymphatic Vascular Diseases |
| title_fullStr | The Impact of Estrogen Receptor in Arterial and Lymphatic Vascular Diseases |
| title_full_unstemmed | The Impact of Estrogen Receptor in Arterial and Lymphatic Vascular Diseases |
| title_short | The Impact of Estrogen Receptor in Arterial and Lymphatic Vascular Diseases |
| title_sort | impact of estrogen receptor in arterial and lymphatic vascular diseases |
| topic | estrogens ERα endothelial cells arterial lymphatic |
| url | https://www.mdpi.com/1422-0067/21/9/3244 |
| work_keys_str_mv | AT coraliefontaine theimpactofestrogenreceptorinarterialandlymphaticvasculardiseases AT florentmorfoisse theimpactofestrogenreceptorinarterialandlymphaticvasculardiseases AT florencetatin theimpactofestrogenreceptorinarterialandlymphaticvasculardiseases AT audreyzamora theimpactofestrogenreceptorinarterialandlymphaticvasculardiseases AT ranazahreddine theimpactofestrogenreceptorinarterialandlymphaticvasculardiseases AT danielhenrion theimpactofestrogenreceptorinarterialandlymphaticvasculardiseases AT jeanfrancoisarnal theimpactofestrogenreceptorinarterialandlymphaticvasculardiseases AT francoiselenfant theimpactofestrogenreceptorinarterialandlymphaticvasculardiseases AT barbaragarmysusini theimpactofestrogenreceptorinarterialandlymphaticvasculardiseases AT coraliefontaine impactofestrogenreceptorinarterialandlymphaticvasculardiseases AT florentmorfoisse impactofestrogenreceptorinarterialandlymphaticvasculardiseases AT florencetatin impactofestrogenreceptorinarterialandlymphaticvasculardiseases AT audreyzamora impactofestrogenreceptorinarterialandlymphaticvasculardiseases AT ranazahreddine impactofestrogenreceptorinarterialandlymphaticvasculardiseases AT danielhenrion impactofestrogenreceptorinarterialandlymphaticvasculardiseases AT jeanfrancoisarnal impactofestrogenreceptorinarterialandlymphaticvasculardiseases AT francoiselenfant impactofestrogenreceptorinarterialandlymphaticvasculardiseases AT barbaragarmysusini impactofestrogenreceptorinarterialandlymphaticvasculardiseases |