Bilateral Alternating Auditory Stimulations Facilitate Fear Extinction and Retrieval
Disruption of fear conditioning, its extinction and its retrieval are at the core of posttraumatic stress disorder (PTSD). Such deficits, especially fear extinction delay, disappear after alternating bilateral stimulations (BLS) during eye movement desensitization and reprocessing (EMDR) therapy. An...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-06-01
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| Series: | Frontiers in Psychology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fpsyg.2017.00990/full |
| _version_ | 1817979442777030656 |
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| author | Sarah Boukezzi Catarina Silva Catarina Silva Bruno Nazarian Pierre-François Rousseau Pierre-François Rousseau Eric Guedj Eric Guedj Eric Guedj Camila Valenzuela-Moguillansky Stéphanie Khalfa |
| author_facet | Sarah Boukezzi Catarina Silva Catarina Silva Bruno Nazarian Pierre-François Rousseau Pierre-François Rousseau Eric Guedj Eric Guedj Eric Guedj Camila Valenzuela-Moguillansky Stéphanie Khalfa |
| author_sort | Sarah Boukezzi |
| collection | DOAJ |
| description | Disruption of fear conditioning, its extinction and its retrieval are at the core of posttraumatic stress disorder (PTSD). Such deficits, especially fear extinction delay, disappear after alternating bilateral stimulations (BLS) during eye movement desensitization and reprocessing (EMDR) therapy. An animal model of fear recovery, based on auditory cued fear conditioning and extinction learning, recently showed that BLS facilitate fear extinction and fear extinction retrieval. Our goal was to determine if these previous results found in animals can be reproduced in humans. Twenty-two healthy participants took part in a classical fear conditioning, extinction, and extinction recall paradigm. Behavioral responses (fear expectations) as well as psychophysiological measures (skin conductance responses, SCRs) were recorded. The results showed a significant fear expectation decrease during fear extinction with BLS. Additionally, SCR for fear extinction retrieval were significantly lower with BLS. Our results demonstrate the importance of BLS to reduce negative emotions, and provide a successful model to further explore the neural mechanisms underlying the sole BLS effect in the EMDR. |
| first_indexed | 2024-04-13T22:42:52Z |
| format | Article |
| id | doaj.art-ad574f2c9a864c77a724000c83412a44 |
| institution | Directory Open Access Journal |
| issn | 1664-1078 |
| language | English |
| last_indexed | 2024-04-13T22:42:52Z |
| publishDate | 2017-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychology |
| spelling | doaj.art-ad574f2c9a864c77a724000c83412a442022-12-22T02:26:33ZengFrontiers Media S.A.Frontiers in Psychology1664-10782017-06-01810.3389/fpsyg.2017.00990260453Bilateral Alternating Auditory Stimulations Facilitate Fear Extinction and RetrievalSarah Boukezzi0Catarina Silva1Catarina Silva2Bruno Nazarian3Pierre-François Rousseau4Pierre-François Rousseau5Eric Guedj6Eric Guedj7Eric Guedj8Camila Valenzuela-Moguillansky9Stéphanie Khalfa10Institut de Neurosciences de la Timone, UMR 7289, Aix Marseille Université and CNRSMarseille, FranceInstitut de Neurosciences de la Timone, UMR 7289, Aix Marseille Université and CNRSMarseille, FranceInstituto Universitário de Lisboa (ISCTE-IUL)Lisboa, PortugalInstitut de Neurosciences de la Timone, UMR 7289, Aix Marseille Université and CNRSMarseille, FranceInstitut de Neurosciences de la Timone, UMR 7289, Aix Marseille Université and CNRSMarseille, FranceService de Psychiatrie, Hôpital d’Instruction des Armées Sainte-AnneToulon, FranceInstitut de Neurosciences de la Timone, UMR 7289, Aix Marseille Université and CNRSMarseille, FranceCentre Européen de Recherche en Imagerie MédicaleMarseille, FranceAssistance Publiques des Hôpitaux de Marseille, Service Central de Biophysique et Médecine NucléaireMarseille, FranceCentro de Estudios de Argumentación y Razonamiento, Facultad de Psicología, Universidad Diego PortalesSantiago, ChileInstitut de Neurosciences de la Timone, UMR 7289, Aix Marseille Université and CNRSMarseille, FranceDisruption of fear conditioning, its extinction and its retrieval are at the core of posttraumatic stress disorder (PTSD). Such deficits, especially fear extinction delay, disappear after alternating bilateral stimulations (BLS) during eye movement desensitization and reprocessing (EMDR) therapy. An animal model of fear recovery, based on auditory cued fear conditioning and extinction learning, recently showed that BLS facilitate fear extinction and fear extinction retrieval. Our goal was to determine if these previous results found in animals can be reproduced in humans. Twenty-two healthy participants took part in a classical fear conditioning, extinction, and extinction recall paradigm. Behavioral responses (fear expectations) as well as psychophysiological measures (skin conductance responses, SCRs) were recorded. The results showed a significant fear expectation decrease during fear extinction with BLS. Additionally, SCR for fear extinction retrieval were significantly lower with BLS. Our results demonstrate the importance of BLS to reduce negative emotions, and provide a successful model to further explore the neural mechanisms underlying the sole BLS effect in the EMDR.http://journal.frontiersin.org/article/10.3389/fpsyg.2017.00990/fullfear conditioningfear extinctionEMDRskin conductancestress |
| spellingShingle | Sarah Boukezzi Catarina Silva Catarina Silva Bruno Nazarian Pierre-François Rousseau Pierre-François Rousseau Eric Guedj Eric Guedj Eric Guedj Camila Valenzuela-Moguillansky Stéphanie Khalfa Bilateral Alternating Auditory Stimulations Facilitate Fear Extinction and Retrieval Frontiers in Psychology fear conditioning fear extinction EMDR skin conductance stress |
| title | Bilateral Alternating Auditory Stimulations Facilitate Fear Extinction and Retrieval |
| title_full | Bilateral Alternating Auditory Stimulations Facilitate Fear Extinction and Retrieval |
| title_fullStr | Bilateral Alternating Auditory Stimulations Facilitate Fear Extinction and Retrieval |
| title_full_unstemmed | Bilateral Alternating Auditory Stimulations Facilitate Fear Extinction and Retrieval |
| title_short | Bilateral Alternating Auditory Stimulations Facilitate Fear Extinction and Retrieval |
| title_sort | bilateral alternating auditory stimulations facilitate fear extinction and retrieval |
| topic | fear conditioning fear extinction EMDR skin conductance stress |
| url | http://journal.frontiersin.org/article/10.3389/fpsyg.2017.00990/full |
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