A novel biguanide derivative, IM176, induces prostate cancer cell death by modulating the AMPK-mTOR and androgen receptor signaling pathways

A novel biguanide derivative, IM176, induces prostate cancer cell death by modulating the AMPK-mTOR and androgen receptor signaling pathways

Background: Metformin and phenformin, biguanide derivatives that are widely used to treat type 2 diabetes mellitus, have recently been shown to exert potential anticancer effects in prostate cancer. This study compared the antiprostate cancer effects of the novel biguanide derivative IM176 with thos...

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Bibliographic Details
Main Authors: Yunlim Kim, Sangjun Yoo, Bumjin Lim, Jun Hyuk Hong, Cheol Kwak, Dalsan You, Jung Jin Hwang, Choung-Soo Kim
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Prostate International
Subjects:
Androgen receptor splice variant
Biguanide
Castration-resistant prostate cancer
Cell death
Online Access:http://www.sciencedirect.com/science/article/pii/S2287888222000666

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