Can molecular hydrogen supplementation reduce exercise-induced oxidative stress in healthy adults? A systematic review and meta-analysis
ObjectiveExercise-induced oxidative stress affects multiple neurophysiological processes, diminishing the exercise performance. Hydrogen (H2) can selectively reduce excessive free radicals, but studies observed its “dual effects” on exercise-induced oxidative stress, that is, increasing or decreasin...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-03-01
|
| Series: | Frontiers in Nutrition |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2024.1328705/full |
| _version_ | 1797246745768361984 |
|---|---|
| author | Yiting Li Renjie Bing Meng Liu Zhangyuting Shang Yan Huang Kaixiang Zhou Dapeng Bao Junhong Zhou |
| author_facet | Yiting Li Renjie Bing Meng Liu Zhangyuting Shang Yan Huang Kaixiang Zhou Dapeng Bao Junhong Zhou |
| author_sort | Yiting Li |
| collection | DOAJ |
| description | ObjectiveExercise-induced oxidative stress affects multiple neurophysiological processes, diminishing the exercise performance. Hydrogen (H2) can selectively reduce excessive free radicals, but studies observed its “dual effects” on exercise-induced oxidative stress, that is, increasing or decreasing the oxidative stress. Therefore, we here conducted a systematic review and meta-analysis to quantitatively assess the influence of H2 on exercise-induced oxidative stress in healthy adults.MethodsWe conducted a systematic review of publications across five databases. The following keywords were used for search strategy: [“hydrogen”[Mesh] or “molecular hydrogen” or “hydrogen rich water” or “hydrogen-rich water” or “hydrogen rich saline”] and [“Oxidative Stress”[Mesh] or “Antioxidative Stress” or “Oxidative Damage” or “Oxidative Injury” or “Oxidative Cleavage”] and [“randomized controlled trial”[Mesh] or “randomized” or “RCT”]. We included trials reporting the effects of H2 on exercise-induced oxidative stress and potential antioxidant capacity post-exercise in healthy adults. Additionally, subgroup analyses were conducted to explore how various elements of the intervention design affected those outcomes.ResultsSix studies, encompassing seven experiments with a total of 76 participants, were included in our analysis. Among these studies, hydrogen-rich water, hydrogen bathing, and hydrogen-rich gas were three forms used in H2 administration. The H2 was applied in different timing, including before, during, or after exercise only, both before and after exercise, and repeatedly over days. Single-dose, multi-dose within 1 day and/or multiple-dose over days were implemented. It was observed that compared to placebo, the effects of H2 on oxidative stress (diacron-reactive oxygen metabolites, d-ROMs) was not significant (SMD = −0.01, 95%CI-0.42 to 0.39, p = 0.94). However, H2 induced greater improvement in antioxidant potential capacity (Biological Antioxidant Potential, BAP) (SMD = 0.29, 95% CI 0.04 to 0.54, p = 0.03) as compared to placebo. Subgroup analyses revealed that H2 supplementation showed greater improvement (SMD = 0.52, 95%CI 0.16 to 0.87, p = 0.02) in the antioxidant potential capacity of intermittent exercises than continuous exercise.ConclusionH2 supplementation can help enhance antioxidant potential capacity in healthy adults, especially in intermittent exercise, but not directly diminish the levels of exercise-induced oxidative stress. Future studies with more rigorous design are needed to examine and confirm these findings.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=364123, Identifier CRD42022364123. |
| first_indexed | 2024-04-24T19:47:41Z |
| format | Article |
| id | doaj.art-ad5d2b1a4191457e8beaa8d44269900f |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-24T19:47:41Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-ad5d2b1a4191457e8beaa8d44269900f2024-03-25T04:40:55ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2024-03-011110.3389/fnut.2024.13287051328705Can molecular hydrogen supplementation reduce exercise-induced oxidative stress in healthy adults? A systematic review and meta-analysisYiting Li0Renjie Bing1Meng Liu2Zhangyuting Shang3Yan Huang4Kaixiang Zhou5Dapeng Bao6Junhong Zhou7College of Sports Medicine and Rehabilitation, Beijing Sport University, Beijing, ChinaCollege of Sports Medicine and Rehabilitation, Beijing Sport University, Beijing, ChinaCollege of Sports Coaching, Beijing Sport University, Beijing, ChinaCollege of Physical Education and Health Management, Chongqing University of Education, Chongqing, ChinaShichahai Sports School, Beijing, ChinaCollege of Physical Education and Health Science, Chongqing Normal University, Chongqing, ChinaChina Institute of Sport and Health Science, Beijing Sport University, Beijing, ChinaHebrew SeniorLife Hinda and Arthur Marcus Institute for Aging Research, Harvard Medical School, Boston, MA, United StatesObjectiveExercise-induced oxidative stress affects multiple neurophysiological processes, diminishing the exercise performance. Hydrogen (H2) can selectively reduce excessive free radicals, but studies observed its “dual effects” on exercise-induced oxidative stress, that is, increasing or decreasing the oxidative stress. Therefore, we here conducted a systematic review and meta-analysis to quantitatively assess the influence of H2 on exercise-induced oxidative stress in healthy adults.MethodsWe conducted a systematic review of publications across five databases. The following keywords were used for search strategy: [“hydrogen”[Mesh] or “molecular hydrogen” or “hydrogen rich water” or “hydrogen-rich water” or “hydrogen rich saline”] and [“Oxidative Stress”[Mesh] or “Antioxidative Stress” or “Oxidative Damage” or “Oxidative Injury” or “Oxidative Cleavage”] and [“randomized controlled trial”[Mesh] or “randomized” or “RCT”]. We included trials reporting the effects of H2 on exercise-induced oxidative stress and potential antioxidant capacity post-exercise in healthy adults. Additionally, subgroup analyses were conducted to explore how various elements of the intervention design affected those outcomes.ResultsSix studies, encompassing seven experiments with a total of 76 participants, were included in our analysis. Among these studies, hydrogen-rich water, hydrogen bathing, and hydrogen-rich gas were three forms used in H2 administration. The H2 was applied in different timing, including before, during, or after exercise only, both before and after exercise, and repeatedly over days. Single-dose, multi-dose within 1 day and/or multiple-dose over days were implemented. It was observed that compared to placebo, the effects of H2 on oxidative stress (diacron-reactive oxygen metabolites, d-ROMs) was not significant (SMD = −0.01, 95%CI-0.42 to 0.39, p = 0.94). However, H2 induced greater improvement in antioxidant potential capacity (Biological Antioxidant Potential, BAP) (SMD = 0.29, 95% CI 0.04 to 0.54, p = 0.03) as compared to placebo. Subgroup analyses revealed that H2 supplementation showed greater improvement (SMD = 0.52, 95%CI 0.16 to 0.87, p = 0.02) in the antioxidant potential capacity of intermittent exercises than continuous exercise.ConclusionH2 supplementation can help enhance antioxidant potential capacity in healthy adults, especially in intermittent exercise, but not directly diminish the levels of exercise-induced oxidative stress. Future studies with more rigorous design are needed to examine and confirm these findings.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=364123, Identifier CRD42022364123.https://www.frontiersin.org/articles/10.3389/fnut.2024.1328705/fullmolecular hydrogenoxidative stressexerciseantioxidant capacityhealthy adults |
| spellingShingle | Yiting Li Renjie Bing Meng Liu Zhangyuting Shang Yan Huang Kaixiang Zhou Dapeng Bao Junhong Zhou Can molecular hydrogen supplementation reduce exercise-induced oxidative stress in healthy adults? A systematic review and meta-analysis Frontiers in Nutrition molecular hydrogen oxidative stress exercise antioxidant capacity healthy adults |
| title | Can molecular hydrogen supplementation reduce exercise-induced oxidative stress in healthy adults? A systematic review and meta-analysis |
| title_full | Can molecular hydrogen supplementation reduce exercise-induced oxidative stress in healthy adults? A systematic review and meta-analysis |
| title_fullStr | Can molecular hydrogen supplementation reduce exercise-induced oxidative stress in healthy adults? A systematic review and meta-analysis |
| title_full_unstemmed | Can molecular hydrogen supplementation reduce exercise-induced oxidative stress in healthy adults? A systematic review and meta-analysis |
| title_short | Can molecular hydrogen supplementation reduce exercise-induced oxidative stress in healthy adults? A systematic review and meta-analysis |
| title_sort | can molecular hydrogen supplementation reduce exercise induced oxidative stress in healthy adults a systematic review and meta analysis |
| topic | molecular hydrogen oxidative stress exercise antioxidant capacity healthy adults |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2024.1328705/full |
| work_keys_str_mv | AT yitingli canmolecularhydrogensupplementationreduceexerciseinducedoxidativestressinhealthyadultsasystematicreviewandmetaanalysis AT renjiebing canmolecularhydrogensupplementationreduceexerciseinducedoxidativestressinhealthyadultsasystematicreviewandmetaanalysis AT mengliu canmolecularhydrogensupplementationreduceexerciseinducedoxidativestressinhealthyadultsasystematicreviewandmetaanalysis AT zhangyutingshang canmolecularhydrogensupplementationreduceexerciseinducedoxidativestressinhealthyadultsasystematicreviewandmetaanalysis AT yanhuang canmolecularhydrogensupplementationreduceexerciseinducedoxidativestressinhealthyadultsasystematicreviewandmetaanalysis AT kaixiangzhou canmolecularhydrogensupplementationreduceexerciseinducedoxidativestressinhealthyadultsasystematicreviewandmetaanalysis AT dapengbao canmolecularhydrogensupplementationreduceexerciseinducedoxidativestressinhealthyadultsasystematicreviewandmetaanalysis AT junhongzhou canmolecularhydrogensupplementationreduceexerciseinducedoxidativestressinhealthyadultsasystematicreviewandmetaanalysis |