Canagliflozin Suppresses Atrial Remodeling in a Canine Atrial Fibrillation Model

Canagliflozin Suppresses Atrial Remodeling in a Canine Atrial Fibrillation Model

Background Recent clinical trials have demonstrated the possible pleiotropic effects of SGLT2 (sodium–glucose cotransporter 2) inhibitors in clinical cardiovascular diseases. Atrial electrical and structural remodeling is important as an atrial fibrillation (AF) substrate. Methods and Results The pr...

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Bibliographic Details
Main Authors: Ryo Nishinarita, Shinichi Niwano, Hiroe Niwano, Hironori Nakamura, Daiki Saito, Tetsuro Sato, Gen Matsuura, Yuki Arakawa, Shuhei Kobayashi, Yuki Shirakawa, Ai Horiguchi, Naruya Ishizue, Tazuru Igarashi, Tomoharu Yoshizawa, Jun Oikawa, Yoshinobu Hara, Takafumi Katsumura, Jun Kishihara, Akira Satoh, Hidehira Fukaya, Hiroyuki Sakagami, Junya Ako
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
atrial fibrillation
atrial remodeling
canagliflozin
oxidative stress
sodium–glucose cotransporter 2 inhibitor
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.119.017483

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