Wnt/β-catenin signalling in ovarian cancer: Insights into its hyperactivation and function in tumorigenesis

Wnt/β-catenin signalling in ovarian cancer: Insights into its hyperactivation and function in tumorigenesis

Abstract Epithelial ovarian cancer (EOC) is the deadliest female malignancy. The Wnt/β-catenin pathway plays critical roles in regulating embryonic development and physiological processes. This pathway is tightly regulated to ensure its proper activity. In the absence of Wnt ligands, β-catenin is de...

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Bibliographic Details
Main Authors: Vu Hong Loan Nguyen, Rebecca Hough, Stefanie Bernaudo, Chun Peng
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Journal of Ovarian Research
Subjects:
Ovarian cancer
Wnt/β-catenin signalling
microRNAs
cancer stem cells
metastasis
tumor angiogenesis
Online Access:https://doi.org/10.1186/s13048-019-0596-z

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