Paeonol at Certain Doses Alleviates Aggressive and Anxiety-Like Behaviours in Two Premenstrual Dysphoric Disorder Rat Models
Premenstrual dysphoric disorder (PMDD) is a severe form of premenstrual syndrome (PMS), a common mental health disturbance associated with several periodic psychological symptoms in women. Selective serotonin reuptake inhibitors (SSRIs) are the first-line treatment for PMS/PMDD patients; however, si...
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Frontiers Media S.A.
2020-04-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2020.00295/full |
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| author | Hao Zhang Xiwen Geng Xiwen Geng Zifa Li Zifa Li Yaqiong Li Kaiyong Xu Kaiyong Xu Hongyun Wu Jinlu Xie Peng Sun Sheng Wei Sheng Wei Mingqi Qiao |
| author_facet | Hao Zhang Xiwen Geng Xiwen Geng Zifa Li Zifa Li Yaqiong Li Kaiyong Xu Kaiyong Xu Hongyun Wu Jinlu Xie Peng Sun Sheng Wei Sheng Wei Mingqi Qiao |
| author_sort | Hao Zhang |
| collection | DOAJ |
| description | Premenstrual dysphoric disorder (PMDD) is a severe form of premenstrual syndrome (PMS), a common mental health disturbance associated with several periodic psychological symptoms in women. Selective serotonin reuptake inhibitors (SSRIs) are the first-line treatment for PMS/PMDD patients; however, side effects are inevitable, especially in long-term treatment. In previous studies, the natural compound paeonol in Moutan Cortex was found to play effective roles in central nervous system disorders with its anti-inflammatory, anti-oxidant, and neuroprotective effects. Consequently, we assume that paeonol might produce positive effects in the treatment of PMS/PMDD. In this study, the open-field test (OFT) and elevated plus maze (EPM) and light dark box (LDB) tests were performed in mice to determine the optimal dose of paeonol for treating anxiety. Then, paeonol was used to treat the progesterone withdrawal (PWD) and resident intruder paradigm (RIP) rat models of PMDD. Using these two reliable models, the OFT and EPM, LDB, and composite aggressive tests were performed to evaluate the effect of the drug on behavioural symptoms of PMDD. From the dosage screening results, the optimal anti-anxiety dose of paeonol was identified as 17.5 mg/kg/d for 7 days. With regard to the effect of paeonol on PMDD rat models, a significantly improvement was found in the behavioural symptoms, but the effective dose varied in different models. For the PWD model rats, treatment with 6.05 mg/kg paeonol could significantly improve anxiety and irritability, while that with 24.23 mg/kg paeonol resulted in anxiety-like effects in behavioural tests. In RIP model rats, treatment with 12.11 mg/kg paeonol demonstrated excellent effects in improving anxiety, particularly irritable emotional behaviour. In conclusion, our study indicates that paeonol is a potential therapeutic compound for PMS/PMDD; it is a drug option that helps establish dosage guidance for treatment of this condition. |
| first_indexed | 2024-12-13T07:48:05Z |
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| id | doaj.art-ad5f07dc38ff4ac4a1f0329772fa82b9 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-13T07:48:05Z |
| publishDate | 2020-04-01 |
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| series | Frontiers in Psychiatry |
| spelling | doaj.art-ad5f07dc38ff4ac4a1f0329772fa82b92022-12-21T23:54:46ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402020-04-011110.3389/fpsyt.2020.00295534933Paeonol at Certain Doses Alleviates Aggressive and Anxiety-Like Behaviours in Two Premenstrual Dysphoric Disorder Rat ModelsHao Zhang0Xiwen Geng1Xiwen Geng2Zifa Li3Zifa Li4Yaqiong Li5Kaiyong Xu6Kaiyong Xu7Hongyun Wu8Jinlu Xie9Peng Sun10Sheng Wei11Sheng Wei12Mingqi Qiao13Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Ji’nan, ChinaKey Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Ji’nan, ChinaExperimental Center, Shandong University of Traditional Chinese Medicine, Ji’nan, ChinaKey Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Ji’nan, ChinaExperimental Center, Shandong University of Traditional Chinese Medicine, Ji’nan, ChinaBozhou Institute of Traditional Chinese Medicine, Anhui Academy of Chinese Medicine Sciences, Bozhou, ChinaKey Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Ji’nan, ChinaExperimental Center, Shandong University of Traditional Chinese Medicine, Ji’nan, ChinaNo. 3 Department of Encephalopathy, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Ji’nan, ChinaKey Laboratory of Vector Biology and Pathogen Control of Zhejiang, School of Medicine, Huzhou University, Huzhou Central Hospital, Huzhou, ChinaKey Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Ji’nan, ChinaKey Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Ji’nan, ChinaExperimental Center, Shandong University of Traditional Chinese Medicine, Ji’nan, ChinaKey Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Ji’nan, ChinaPremenstrual dysphoric disorder (PMDD) is a severe form of premenstrual syndrome (PMS), a common mental health disturbance associated with several periodic psychological symptoms in women. Selective serotonin reuptake inhibitors (SSRIs) are the first-line treatment for PMS/PMDD patients; however, side effects are inevitable, especially in long-term treatment. In previous studies, the natural compound paeonol in Moutan Cortex was found to play effective roles in central nervous system disorders with its anti-inflammatory, anti-oxidant, and neuroprotective effects. Consequently, we assume that paeonol might produce positive effects in the treatment of PMS/PMDD. In this study, the open-field test (OFT) and elevated plus maze (EPM) and light dark box (LDB) tests were performed in mice to determine the optimal dose of paeonol for treating anxiety. Then, paeonol was used to treat the progesterone withdrawal (PWD) and resident intruder paradigm (RIP) rat models of PMDD. Using these two reliable models, the OFT and EPM, LDB, and composite aggressive tests were performed to evaluate the effect of the drug on behavioural symptoms of PMDD. From the dosage screening results, the optimal anti-anxiety dose of paeonol was identified as 17.5 mg/kg/d for 7 days. With regard to the effect of paeonol on PMDD rat models, a significantly improvement was found in the behavioural symptoms, but the effective dose varied in different models. For the PWD model rats, treatment with 6.05 mg/kg paeonol could significantly improve anxiety and irritability, while that with 24.23 mg/kg paeonol resulted in anxiety-like effects in behavioural tests. In RIP model rats, treatment with 12.11 mg/kg paeonol demonstrated excellent effects in improving anxiety, particularly irritable emotional behaviour. In conclusion, our study indicates that paeonol is a potential therapeutic compound for PMS/PMDD; it is a drug option that helps establish dosage guidance for treatment of this condition.https://www.frontiersin.org/article/10.3389/fpsyt.2020.00295/fullpaeonolpremenstrual dysphoric disorderrat modelsresident intruderprogesterone withdrawal |
| spellingShingle | Hao Zhang Xiwen Geng Xiwen Geng Zifa Li Zifa Li Yaqiong Li Kaiyong Xu Kaiyong Xu Hongyun Wu Jinlu Xie Peng Sun Sheng Wei Sheng Wei Mingqi Qiao Paeonol at Certain Doses Alleviates Aggressive and Anxiety-Like Behaviours in Two Premenstrual Dysphoric Disorder Rat Models Frontiers in Psychiatry paeonol premenstrual dysphoric disorder rat models resident intruder progesterone withdrawal |
| title | Paeonol at Certain Doses Alleviates Aggressive and Anxiety-Like Behaviours in Two Premenstrual Dysphoric Disorder Rat Models |
| title_full | Paeonol at Certain Doses Alleviates Aggressive and Anxiety-Like Behaviours in Two Premenstrual Dysphoric Disorder Rat Models |
| title_fullStr | Paeonol at Certain Doses Alleviates Aggressive and Anxiety-Like Behaviours in Two Premenstrual Dysphoric Disorder Rat Models |
| title_full_unstemmed | Paeonol at Certain Doses Alleviates Aggressive and Anxiety-Like Behaviours in Two Premenstrual Dysphoric Disorder Rat Models |
| title_short | Paeonol at Certain Doses Alleviates Aggressive and Anxiety-Like Behaviours in Two Premenstrual Dysphoric Disorder Rat Models |
| title_sort | paeonol at certain doses alleviates aggressive and anxiety like behaviours in two premenstrual dysphoric disorder rat models |
| topic | paeonol premenstrual dysphoric disorder rat models resident intruder progesterone withdrawal |
| url | https://www.frontiersin.org/article/10.3389/fpsyt.2020.00295/full |
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