Real-world data of long-term survival in patients with T-cell lymphoma who underwent stem cell transplantation
Abstract This study aimed to identify the benefits of autologous-stem cell transplantation (auto-SCT) and allogeneic-SCT (allo-SCT) in patients with aggressive T-cell lymphomas to aid in the selection of transplantation type in clinical practice. This study retrospectively analyzed data from 598 pat...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-06-01
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| Series: | Blood Cancer Journal |
| Online Access: | https://doi.org/10.1038/s41408-023-00868-w |
| _version_ | 1827910961497899008 |
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| author | Dong Won Baek Joon Ho Moon Jae Hoon Lee Ka-Won Kang Ho Sup Lee Hyeon-Seok Eom Enuyoung Lee Ji Hyun Lee Jeong-Ok Lee Seong Kyu Park Seok Jin Kim Keon Hee Yoo Sung-Soo Yoon Youngil Koh Hyoung Jin Kang Jong-Ho Won Chuhl Joo Lyu Seung Min Hahn Jung-Hee Lee Joon Seong Park Jae-Cheol Jo Yeung-Chul Mun Deok-Hwan Yang Ga-Young Song Sung-Nam Lim Sang Kyun Sohn The Korean Society of Blood and Marrow Transplantation |
| author_facet | Dong Won Baek Joon Ho Moon Jae Hoon Lee Ka-Won Kang Ho Sup Lee Hyeon-Seok Eom Enuyoung Lee Ji Hyun Lee Jeong-Ok Lee Seong Kyu Park Seok Jin Kim Keon Hee Yoo Sung-Soo Yoon Youngil Koh Hyoung Jin Kang Jong-Ho Won Chuhl Joo Lyu Seung Min Hahn Jung-Hee Lee Joon Seong Park Jae-Cheol Jo Yeung-Chul Mun Deok-Hwan Yang Ga-Young Song Sung-Nam Lim Sang Kyun Sohn The Korean Society of Blood and Marrow Transplantation |
| author_sort | Dong Won Baek |
| collection | DOAJ |
| description | Abstract This study aimed to identify the benefits of autologous-stem cell transplantation (auto-SCT) and allogeneic-SCT (allo-SCT) in patients with aggressive T-cell lymphomas to aid in the selection of transplantation type in clinical practice. This study retrospectively analyzed data from 598 patients who underwent transplantation for T-cell lymphomas from 2010 to 2020. In total, 317 patients underwent up-front SCT as consolidation therapy. The 3-year progression-free survival (PFS) and overall survival (OS) were 68.7% and 76.1%, respectively. Patients who underwent auto-SCT had significantly better OS (p = 0.026) than those who underwent allo-SCT; however, no statistical difference in PFS was found. Transplantation was used as a salvage therapy in 188 patients who had relapsed/refractory disease. Overall, 96 (51.1%) patients underwent auto-SCT and 92 (48.9%) patients underwent allo-SCT. Auto-SCT improved long-term survival in patients with complete remission (CR). Allo-SCT demonstrated better 3-year PFS in patients with partial remission and relapsed/refractory disease status. However, >50% of patients died within 1 year of allo-SCT. As a consolidative therapy, up-front auto-SCT demonstrated a survival benefit. Auto-SCT was also effective in patients who achieved CR after salvage therapy. If the disease persists or cannot be controlled, allo-SCT may be considered with reduced intensity conditioning. |
| first_indexed | 2024-03-13T01:57:40Z |
| format | Article |
| id | doaj.art-ad5f4ed87d024b63a22b0b70b67646ee |
| institution | Directory Open Access Journal |
| issn | 2044-5385 |
| language | English |
| last_indexed | 2024-03-13T01:57:40Z |
| publishDate | 2023-06-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Blood Cancer Journal |
| spelling | doaj.art-ad5f4ed87d024b63a22b0b70b67646ee2023-07-02T11:08:05ZengNature Publishing GroupBlood Cancer Journal2044-53852023-06-011311810.1038/s41408-023-00868-wReal-world data of long-term survival in patients with T-cell lymphoma who underwent stem cell transplantationDong Won Baek0Joon Ho Moon1Jae Hoon Lee2Ka-Won Kang3Ho Sup Lee4Hyeon-Seok Eom5Enuyoung Lee6Ji Hyun Lee7Jeong-Ok Lee8Seong Kyu Park9Seok Jin Kim10Keon Hee Yoo11Sung-Soo Yoon12Youngil Koh13Hyoung Jin Kang14Jong-Ho Won15Chuhl Joo Lyu16Seung Min Hahn17Jung-Hee Lee18Joon Seong Park19Jae-Cheol Jo20Yeung-Chul Mun21Deok-Hwan Yang22Ga-Young Song23Sung-Nam Lim24Sang Kyun Sohn25The Korean Society of Blood and Marrow TransplantationDepartment of Hematology/Oncology, Kyungpook National University Hospital, School of Medicine, Kyungpook National UniversityDepartment of Hematology/Oncology, Kyungpook National University Hospital, School of Medicine, Kyungpook National UniversityHematology, Gachon University Gil Medical CenterDivision of Hematology-Oncology, Department of Internal Medicine, Korea University College of MedicineDivision of Hematology, Department of Internal Medicine, Kosin University College of Medicine, Kosin University Gospel HospitalCenter for Hematologic Malignancy, National Cancer CenterCenter for Hematologic Malignancy, National Cancer CenterDivision of Hematology-Oncology, Department of Internal Medicine, Dong-A University College of MedicineDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of MedicineDivision of Hematology-Oncology, Department of Internal Medicine, Soonchunhyang University Bucheon HospitalDivision of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Internal Medicine, Seoul National University HospitalDepartment of Internal Medicine, Seoul National University HospitalDepartment of Pediatrics, Seoul National University College of Medicine, Seoul National University Cancer Research Institute, Seoul National University Children’s HospitalDivision of Hematology-Oncology, Department of Internal Medicine, Soonchunhyang University Seoul HospitalDepartment of Pediatric Hematology Oncology, Severance Hospital, Yonsei UniversityDepartment of Pediatric Hematology Oncology, Severance Hospital, Yonsei UniversityDepartment of Hematology, Asan Medical Center, University of Ulsan College of MedicineDepartment of Hematology-Oncology, Ajou University School of MedicineDepartment of Hematology and Oncology, Ulsan University Hospital, University of Ulsan College of MedicineDepartment of Internal Medicine, Ewha Womans University School of MedicineDepartment of Hematology-Oncology, Chonnam National University Hwasun Hospital, Chonnam National University Medical SchoolDepartment of Hematology-Oncology, Chonnam National University Hwasun Hospital, Chonnam National University Medical SchoolDivision of Hematology-Oncology, Department of Internal Medicine, Inje University College of Medicine, Haeundae Paik HospitalDepartment of Hematology/Oncology, Kyungpook National University Hospital, School of Medicine, Kyungpook National UniversityAbstract This study aimed to identify the benefits of autologous-stem cell transplantation (auto-SCT) and allogeneic-SCT (allo-SCT) in patients with aggressive T-cell lymphomas to aid in the selection of transplantation type in clinical practice. This study retrospectively analyzed data from 598 patients who underwent transplantation for T-cell lymphomas from 2010 to 2020. In total, 317 patients underwent up-front SCT as consolidation therapy. The 3-year progression-free survival (PFS) and overall survival (OS) were 68.7% and 76.1%, respectively. Patients who underwent auto-SCT had significantly better OS (p = 0.026) than those who underwent allo-SCT; however, no statistical difference in PFS was found. Transplantation was used as a salvage therapy in 188 patients who had relapsed/refractory disease. Overall, 96 (51.1%) patients underwent auto-SCT and 92 (48.9%) patients underwent allo-SCT. Auto-SCT improved long-term survival in patients with complete remission (CR). Allo-SCT demonstrated better 3-year PFS in patients with partial remission and relapsed/refractory disease status. However, >50% of patients died within 1 year of allo-SCT. As a consolidative therapy, up-front auto-SCT demonstrated a survival benefit. Auto-SCT was also effective in patients who achieved CR after salvage therapy. If the disease persists or cannot be controlled, allo-SCT may be considered with reduced intensity conditioning.https://doi.org/10.1038/s41408-023-00868-w |
| spellingShingle | Dong Won Baek Joon Ho Moon Jae Hoon Lee Ka-Won Kang Ho Sup Lee Hyeon-Seok Eom Enuyoung Lee Ji Hyun Lee Jeong-Ok Lee Seong Kyu Park Seok Jin Kim Keon Hee Yoo Sung-Soo Yoon Youngil Koh Hyoung Jin Kang Jong-Ho Won Chuhl Joo Lyu Seung Min Hahn Jung-Hee Lee Joon Seong Park Jae-Cheol Jo Yeung-Chul Mun Deok-Hwan Yang Ga-Young Song Sung-Nam Lim Sang Kyun Sohn The Korean Society of Blood and Marrow Transplantation Real-world data of long-term survival in patients with T-cell lymphoma who underwent stem cell transplantation Blood Cancer Journal |
| title | Real-world data of long-term survival in patients with T-cell lymphoma who underwent stem cell transplantation |
| title_full | Real-world data of long-term survival in patients with T-cell lymphoma who underwent stem cell transplantation |
| title_fullStr | Real-world data of long-term survival in patients with T-cell lymphoma who underwent stem cell transplantation |
| title_full_unstemmed | Real-world data of long-term survival in patients with T-cell lymphoma who underwent stem cell transplantation |
| title_short | Real-world data of long-term survival in patients with T-cell lymphoma who underwent stem cell transplantation |
| title_sort | real world data of long term survival in patients with t cell lymphoma who underwent stem cell transplantation |
| url | https://doi.org/10.1038/s41408-023-00868-w |
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