Prognostic Implications of 18-FDG Positron Emission Tomography/Computed Tomography in Resectable Pancreatic Cancer
There are currently no known preoperative factors for determining the prognosis in pancreatic cancer. The aim of this study was to examine the role of 18-fluorodeoxyglucose (18-FDG) positron emission tomography/computed tomography (18-FDG-PET/CT) as a prognostic factor for patients with resectable p...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-07-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/9/7/2169 |
| _version_ | 1797562949262376960 |
|---|---|
| author | Cosimo Sperti Alberto Friziero Simone Serafini Sergio Bissoli Alberto Ponzoni Andrea Grego Emanuele Grego Lucia Moletta |
| author_facet | Cosimo Sperti Alberto Friziero Simone Serafini Sergio Bissoli Alberto Ponzoni Andrea Grego Emanuele Grego Lucia Moletta |
| author_sort | Cosimo Sperti |
| collection | DOAJ |
| description | There are currently no known preoperative factors for determining the prognosis in pancreatic cancer. The aim of this study was to examine the role of 18-fluorodeoxyglucose (18-FDG) positron emission tomography/computed tomography (18-FDG-PET/CT) as a prognostic factor for patients with resectable pancreatic cancer. Data were obtained from a retrospective analysis of patients who had a preoperative PET scan and then underwent pancreatic resection from January 2007 to December 2015. The maximum standardized uptake value (SUVmax) of 18-FDG-PET/CT was calculated. Patients were divided into high (>3.65) and low (≤3.65) SUVmax groups, and compared in terms of their TNM classification (Union for International Cancer Contro classification), pathological grade, surgical treatment, state of resection margins, lymph node involvement, age, sex, diabetes and serum Carbohydrate Antigen 19-9 (CA 19-9) levels. The study involved 144 patients, 82 with high SUVmax pancreatic cancer and 62 with low SUVmax disease. The two groups’ disease-free and overall survival rates were significantly influenced by tumor stage, lymph node involvement, pathological grade, resection margins and SUVmax. Patients with an SUVmax ≤ 3.65 had a significantly better survival than those with SUVmax > 3.65 (<i>p</i> < 0.001). The same variables were independent predictors of survival on multivariate analysis. The SUVmax calculated with 18-FDG-PET/CT is an important prognostic factor for patients with pancreatic cancer, and may be useful in decisions concerning patients’ therapeutic management. |
| first_indexed | 2024-03-10T18:35:51Z |
| format | Article |
| id | doaj.art-ad60af28a6c14b1784e13822ed07a75e |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T18:35:51Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-ad60af28a6c14b1784e13822ed07a75e2023-11-20T06:15:55ZengMDPI AGJournal of Clinical Medicine2077-03832020-07-0197216910.3390/jcm9072169Prognostic Implications of 18-FDG Positron Emission Tomography/Computed Tomography in Resectable Pancreatic CancerCosimo Sperti0Alberto Friziero1Simone Serafini2Sergio Bissoli3Alberto Ponzoni4Andrea Grego5Emanuele Grego6Lucia Moletta7Department of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padua, Via Giustiniani 2, 35128 Padua, ItalyDepartment of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padua, Via Giustiniani 2, 35128 Padua, ItalyDepartment of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padua, Via Giustiniani 2, 35128 Padua, ItalyNuclear Medicine, Belluno General Hospital, Viale Europa 22, 32100 Belluno, ItalyDepartment of Radiology, Padua General Hospital, Via Giustiniani 2, 35128 Padua, ItalyDepartment of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padua, Via Giustiniani 2, 35128 Padua, ItalyUniversity of Padua, Via Giustiniani 2, 35128 Padua, ItalyDepartment of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of Padua, Via Giustiniani 2, 35128 Padua, ItalyThere are currently no known preoperative factors for determining the prognosis in pancreatic cancer. The aim of this study was to examine the role of 18-fluorodeoxyglucose (18-FDG) positron emission tomography/computed tomography (18-FDG-PET/CT) as a prognostic factor for patients with resectable pancreatic cancer. Data were obtained from a retrospective analysis of patients who had a preoperative PET scan and then underwent pancreatic resection from January 2007 to December 2015. The maximum standardized uptake value (SUVmax) of 18-FDG-PET/CT was calculated. Patients were divided into high (>3.65) and low (≤3.65) SUVmax groups, and compared in terms of their TNM classification (Union for International Cancer Contro classification), pathological grade, surgical treatment, state of resection margins, lymph node involvement, age, sex, diabetes and serum Carbohydrate Antigen 19-9 (CA 19-9) levels. The study involved 144 patients, 82 with high SUVmax pancreatic cancer and 62 with low SUVmax disease. The two groups’ disease-free and overall survival rates were significantly influenced by tumor stage, lymph node involvement, pathological grade, resection margins and SUVmax. Patients with an SUVmax ≤ 3.65 had a significantly better survival than those with SUVmax > 3.65 (<i>p</i> < 0.001). The same variables were independent predictors of survival on multivariate analysis. The SUVmax calculated with 18-FDG-PET/CT is an important prognostic factor for patients with pancreatic cancer, and may be useful in decisions concerning patients’ therapeutic management.https://www.mdpi.com/2077-0383/9/7/2169fluorodeoxyglucosepancreatectomypancreatic cancerpositron emission tomographyprognosisstandardized uptake value |
| spellingShingle | Cosimo Sperti Alberto Friziero Simone Serafini Sergio Bissoli Alberto Ponzoni Andrea Grego Emanuele Grego Lucia Moletta Prognostic Implications of 18-FDG Positron Emission Tomography/Computed Tomography in Resectable Pancreatic Cancer Journal of Clinical Medicine fluorodeoxyglucose pancreatectomy pancreatic cancer positron emission tomography prognosis standardized uptake value |
| title | Prognostic Implications of 18-FDG Positron Emission Tomography/Computed Tomography in Resectable Pancreatic Cancer |
| title_full | Prognostic Implications of 18-FDG Positron Emission Tomography/Computed Tomography in Resectable Pancreatic Cancer |
| title_fullStr | Prognostic Implications of 18-FDG Positron Emission Tomography/Computed Tomography in Resectable Pancreatic Cancer |
| title_full_unstemmed | Prognostic Implications of 18-FDG Positron Emission Tomography/Computed Tomography in Resectable Pancreatic Cancer |
| title_short | Prognostic Implications of 18-FDG Positron Emission Tomography/Computed Tomography in Resectable Pancreatic Cancer |
| title_sort | prognostic implications of 18 fdg positron emission tomography computed tomography in resectable pancreatic cancer |
| topic | fluorodeoxyglucose pancreatectomy pancreatic cancer positron emission tomography prognosis standardized uptake value |
| url | https://www.mdpi.com/2077-0383/9/7/2169 |
| work_keys_str_mv | AT cosimosperti prognosticimplicationsof18fdgpositronemissiontomographycomputedtomographyinresectablepancreaticcancer AT albertofriziero prognosticimplicationsof18fdgpositronemissiontomographycomputedtomographyinresectablepancreaticcancer AT simoneserafini prognosticimplicationsof18fdgpositronemissiontomographycomputedtomographyinresectablepancreaticcancer AT sergiobissoli prognosticimplicationsof18fdgpositronemissiontomographycomputedtomographyinresectablepancreaticcancer AT albertoponzoni prognosticimplicationsof18fdgpositronemissiontomographycomputedtomographyinresectablepancreaticcancer AT andreagrego prognosticimplicationsof18fdgpositronemissiontomographycomputedtomographyinresectablepancreaticcancer AT emanuelegrego prognosticimplicationsof18fdgpositronemissiontomographycomputedtomographyinresectablepancreaticcancer AT luciamoletta prognosticimplicationsof18fdgpositronemissiontomographycomputedtomographyinresectablepancreaticcancer |