COVID-19 Vaccination, Adverse Effect, and SARS-CoV-2 Infection among Couples in Infertility Clinic: A Prospective Study
Background: Although periconception vaccination is important for maternal and neonatal health, vaccine hesitancy could pose a challenge to achieving a healthy pregnancy in infertile women. We assessed the prevalence of coronavirus disease 2019 (COVID-19) booster vaccination, associated factors, adve...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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IMR Press
2023-12-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/CEOG/50/12/10.31083/j.ceog5012267 |
| _version_ | 1797365394655150080 |
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| author | Seul Gee Park Eunsun Kwak Taemi Kim Young June Choe Seung-Ah Choe Jee Hyun Kim |
| author_facet | Seul Gee Park Eunsun Kwak Taemi Kim Young June Choe Seung-Ah Choe Jee Hyun Kim |
| author_sort | Seul Gee Park |
| collection | DOAJ |
| description | Background: Although periconception vaccination is important for maternal and neonatal health, vaccine hesitancy could pose a challenge to achieving a healthy pregnancy in infertile women. We assessed the prevalence of coronavirus disease 2019 (COVID-19) booster vaccination, associated factors, adverse event after vaccination, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among women seeking fertility treatment. Methods: We used the data from participants of the Pregnancy and Urban Environment study (PRUNE study), which is a prospective observational study designed to explore the association between pregnancy and the urban environment in infertile couples. From October 2019 to September 2021, a total of 534 patients provided informed consent and participated in the first and second rounds of a mobile survey conducted at six-month intervals. In the second and third rounds of the survey, we included questions about COVID-19 vaccination and SARS-CoV-2 infection. Adjusted risk ratios (aRR) were calculated for COVID-19 booster vaccination and SARS-CoV-2 infection. Results: All the women participating in the survey had completed the primary series of COVID-19 vaccination. The booster vaccination rate was 38.5%, and the prevalence of SARS-CoV-2 infection was 34.4%. The likelihood of receiving a booster vaccination was higher when women reported alcohol consumption (aRR = 1.90, 95% confidence interval (CI): 1.03–3.51, p = 0.041). SARS-CoV-2 infection was inversely associated with nulliparity (aRR = 0.44, 95% CI: 0.17–1.09, p = 0.077). Among the women vaccinated against COVID-19, 44.3% of respondents reported at least one adverse reaction after receiving the vaccine. Conclusions: All the women participating in the survey had completed primary series of COVID-19 vaccination. The booster vaccination rate was 38.5%, and the prevalence of SARS-CoV-2 infection was 34.4%. Among the vaccinated women, 44.3% reported experiencing at least one adverse reaction after receiving the COVID-19 vaccine. Fever/chilling was the most common (61.8%), followed by abnormal vaginal bleeding/menstrual irregularity (41.8%). A targeted education program by health professionals is needed to promote the benefits of periconception vaccination and reduce the resistance to the COVID-19 vaccine among infertile couples. Clinical Trial Registration: The study was registered at Clinical Research Information Service (https://cris.nih.go.kr/cris/info/dataset.do), registration number: KCT0003560. |
| first_indexed | 2024-03-08T16:48:15Z |
| format | Article |
| id | doaj.art-ad62518d6c0844939f9ddd86c415078c |
| institution | Directory Open Access Journal |
| issn | 0390-6663 |
| language | English |
| last_indexed | 2024-03-08T16:48:15Z |
| publishDate | 2023-12-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj.art-ad62518d6c0844939f9ddd86c415078c2024-01-05T07:27:09ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632023-12-01501226710.31083/j.ceog5012267S0390-6663(23)02222-4COVID-19 Vaccination, Adverse Effect, and SARS-CoV-2 Infection among Couples in Infertility Clinic: A Prospective StudySeul Gee Park0Eunsun Kwak1Taemi Kim2Young June Choe3Seung-Ah Choe4Jee Hyun Kim5CHA Fertility Center Bundang, CHA University, 13488 Gyeonggi-Do, Republic of KoreaDepartment of Preventive Medicine, Korea University College of Medicine, 13520 Seoul, Republic of KoreaDepartment of Public Health Science, Korea University, 13520 Seoul, Republic of KoreaDepartment of Pediatrics, Korea University Anam Hospital, 13520 Seoul, Republic of KoreaDepartment of Preventive Medicine, Korea University College of Medicine, 13520 Seoul, Republic of KoreaCHA Fertility Center Bundang, CHA University, 13488 Gyeonggi-Do, Republic of KoreaBackground: Although periconception vaccination is important for maternal and neonatal health, vaccine hesitancy could pose a challenge to achieving a healthy pregnancy in infertile women. We assessed the prevalence of coronavirus disease 2019 (COVID-19) booster vaccination, associated factors, adverse event after vaccination, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among women seeking fertility treatment. Methods: We used the data from participants of the Pregnancy and Urban Environment study (PRUNE study), which is a prospective observational study designed to explore the association between pregnancy and the urban environment in infertile couples. From October 2019 to September 2021, a total of 534 patients provided informed consent and participated in the first and second rounds of a mobile survey conducted at six-month intervals. In the second and third rounds of the survey, we included questions about COVID-19 vaccination and SARS-CoV-2 infection. Adjusted risk ratios (aRR) were calculated for COVID-19 booster vaccination and SARS-CoV-2 infection. Results: All the women participating in the survey had completed the primary series of COVID-19 vaccination. The booster vaccination rate was 38.5%, and the prevalence of SARS-CoV-2 infection was 34.4%. The likelihood of receiving a booster vaccination was higher when women reported alcohol consumption (aRR = 1.90, 95% confidence interval (CI): 1.03–3.51, p = 0.041). SARS-CoV-2 infection was inversely associated with nulliparity (aRR = 0.44, 95% CI: 0.17–1.09, p = 0.077). Among the women vaccinated against COVID-19, 44.3% of respondents reported at least one adverse reaction after receiving the vaccine. Conclusions: All the women participating in the survey had completed primary series of COVID-19 vaccination. The booster vaccination rate was 38.5%, and the prevalence of SARS-CoV-2 infection was 34.4%. Among the vaccinated women, 44.3% reported experiencing at least one adverse reaction after receiving the COVID-19 vaccine. Fever/chilling was the most common (61.8%), followed by abnormal vaginal bleeding/menstrual irregularity (41.8%). A targeted education program by health professionals is needed to promote the benefits of periconception vaccination and reduce the resistance to the COVID-19 vaccine among infertile couples. Clinical Trial Registration: The study was registered at Clinical Research Information Service (https://cris.nih.go.kr/cris/info/dataset.do), registration number: KCT0003560.https://www.imrpress.com/journal/CEOG/50/12/10.31083/j.ceog5012267covid-19booster vaccinationinfertilityvaccine hesitancyadverse effectsars-cov-2 |
| spellingShingle | Seul Gee Park Eunsun Kwak Taemi Kim Young June Choe Seung-Ah Choe Jee Hyun Kim COVID-19 Vaccination, Adverse Effect, and SARS-CoV-2 Infection among Couples in Infertility Clinic: A Prospective Study Clinical and Experimental Obstetrics & Gynecology covid-19 booster vaccination infertility vaccine hesitancy adverse effect sars-cov-2 |
| title | COVID-19 Vaccination, Adverse Effect, and SARS-CoV-2 Infection among Couples in Infertility Clinic: A Prospective Study |
| title_full | COVID-19 Vaccination, Adverse Effect, and SARS-CoV-2 Infection among Couples in Infertility Clinic: A Prospective Study |
| title_fullStr | COVID-19 Vaccination, Adverse Effect, and SARS-CoV-2 Infection among Couples in Infertility Clinic: A Prospective Study |
| title_full_unstemmed | COVID-19 Vaccination, Adverse Effect, and SARS-CoV-2 Infection among Couples in Infertility Clinic: A Prospective Study |
| title_short | COVID-19 Vaccination, Adverse Effect, and SARS-CoV-2 Infection among Couples in Infertility Clinic: A Prospective Study |
| title_sort | covid 19 vaccination adverse effect and sars cov 2 infection among couples in infertility clinic a prospective study |
| topic | covid-19 booster vaccination infertility vaccine hesitancy adverse effect sars-cov-2 |
| url | https://www.imrpress.com/journal/CEOG/50/12/10.31083/j.ceog5012267 |
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