CDK9 activity switch associated with AFF1 and HEXIM1 controls differentiation initiation from epidermal progenitors

CDK9 activity switch associated with AFF1 and HEXIM1 controls differentiation initiation from epidermal progenitors

Epidermal progenitors are poised for differentiation, which allows for continual balance of self-renewal and differentiation. Here they show that the Super Elongation Complex regulates this process through direct regulation of a set of rapid response genes that involves a CDK9 activity switch.

Bibliografiske detaljer
Main Authors: Sarah M. Lloyd, Daniel B. Leon, Mari O. Brady, Deborah Rodriguez, Madison P. McReynolds, Junghun Kweon, Amy E. Neely, Laura A. Blumensaadt, Patric J. Ho, Xiaomin Bao
Format: Article
Sprog:English
Udgivet: Nature Portfolio 2022-07-01
Serier:Nature Communications
Online adgang:https://doi.org/10.1038/s41467-022-32098-2
Beskrivelse
Summary:Epidermal progenitors are poised for differentiation, which allows for continual balance of self-renewal and differentiation. Here they show that the Super Elongation Complex regulates this process through direct regulation of a set of rapid response genes that involves a CDK9 activity switch.
ISSN:2041-1723

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