Impact of HNF4α disrupted expression on hepatocellular carcinoma cells sensitivity to oncogenic pathways inhibitors

Impact of HNF4α disrupted expression on hepatocellular carcinoma cells sensitivity to oncogenic pathways inhibitors

Introduction. Hepatocellular carcinoma (HCC) is characterized by aggressive course, high lethality rate and resistance to current systemic treatment. Analysis of molecular aberrations associated with HCC pathogenesis that control biological properties of HCC allows to evaluate potential efficacy of...

Full description

Bibliographic Details
Main Authors:	A. S. Makarova, O. M. Krivtsova, M. S. Chesnokov, N. I. Lazarevich
Format:	Article
Language:	Russian
Published:	ABV-press 2017-10-01
Series:	Успехи молекулярной онкологии
Subjects:	hnf4α гепатоцеллюлярная карцинома определение действия противоопухолевых ингибиторов рапамицин палбоциклиб y27632
Online Access:	https://umo.abvpress.ru/jour/article/view/105

Similar Items

Potential of the use of methylation biomarkers for diagnostics and prognosis of hepatocellular carcinoma in liquid biopsy
by: I. F. Kustova, et al.
Published: (2019-01-01)

Methods for the detection of tumor-specific single nucleotide somatic mutations in plasma cDNA samples
by: L. M. Dyakov, et al.
Published: (2022-10-01)

Identification of a new methylation site in the Sept9 promoter region for the diagnosis of hepatocellular carcinoma
by: N. L. Lazarevich, et al.
Published: (2019-12-01)

Disruption of Tumor Suppressors HNF4α/HNF1α Causes Tumorigenesis in Liver
by: Aamir Salam Teeli, et al.
Published: (2021-10-01)

Successful antiviral therapy for chronic hepatitis C in a patient after surgery for hepatocellular carcinoma (a clinical observation)
by: I. G. Nikitin, et al.
Published: (2018-08-01)

РАЗВИТИЕ ГЕПАТОЦЕЛЛЮЛЯРНОЙ КАРЦИНОМЫ В ИСХОДЕ ХРОНИЧЕСКОЙ ДЕЛЬТА-ИНФЕКЦИИ
by: Л. Ю. Ильченко, et al.
Published: (2014-08-01)

Press-reliz44-e ezhegodnoe zasedanie Evropeyskoy assotsiatsii po izucheniyu pecheni (EASL)
by: - -
Published: (2009-06-01)

The role of calcineurin inhibitors in the progression of hepatocellular carcinoma after liver transplantation
by: O. D. Olisov, et al.
Published: (2022-09-01)

ERADICATION OF HCV INFECTION IN PATIENTS WITH LIVER CIRRHOSIS: FACTOR OF CANCER PREVENTION OR CARCINOGENESIS?
by: N. A. Malinina, et al.
Published: (2019-06-01)

Combined extensive liver resections in patients with locally advanced hepatocellular cancer – clinical cases
by: D. V. Sidorov, et al.
Published: (2020-06-01)

HEPATOCELLULAR CARCINOMA. RECENT ADVANCES IN DIAGNOSIS AND TREATMENT
by: T. Y. Chernobrovkina, et al.
Published: (2016-03-01)

Asymptomatic Hepatocellular Carcinoma (Clinical Case)
by: A. S. Shkaraburov, et al.
Published: (2022-10-01)

Clinical and Epidemiological Characteristics of Hepatocellular Carcinoma in the Republic of Saha (Yakutia)
by: S. S. Sleptsova, et al.
Published: (2020-07-01)

Hepatocellular Carcinoma in the Adolescent With Classical Familial Adenomatous Polyposis: Clinical Case
by: Svetlana Ya. Volgina, et al.
Published: (2020-09-01)

Molecular Dynamics Simulations Predict that rSNP Located in the <i>HNF-1α</i> Gene Promotor Region Linked with MODY3 and Hepatocellular Carcinoma Promotes Stronger Binding of the HNF-4α Transcription Factor
by: Eva Španinger, et al.
Published: (2020-12-01)

Experience of Hepatocellular Cancer Therapy with Multikinase Inhibitors in the Republic of Bashkortostan
by: Sh. Kh. Gantsev, et al.
Published: (2020-11-01)

The Roles of Long Noncoding RNAs HNF1α-AS1 and HNF4α-AS1 in Drug Metabolism and Human Diseases
by: Liming Chen, et al.
Published: (2020-06-01)

Hepatocellular Carcinoma: Aetiology and Mechanisms of Development. A Literature Review
by: K. V. Menshikov, et al.
Published: (2022-07-01)

ГЕПАТИТ ДЕЛЬТА: ЭТИОЛОГИЯ, КЛИНИКА, ДИАГНОСТИКА, ТЕРАПИЯ (ЛЕКЦИЯ ДЛЯ ПРАКТИЧЕСКИХ ВРАЧЕЙ)
by: Т. В. Кожанова, et al.
Published: (2014-10-01)

The prevalence of viral hepatitis D in the world
by: V. G. Akimkin, et al.
Published: (2022-07-01)

HNF4α isoforms: the fraternal twin master regulators of liver function
by: Sarah H. Radi, et al.
Published: (2023-08-01)

Protective roles of adiponectin and molecular signatures of HNF4α and PPARα as downstream targets of adiponectin in pancreatic β cells
by: Toshiharu Onodera, et al.
Published: (2023-12-01)

LncRNA Hnf4αos exacerbates liver ischemia/reperfusion injury in mice via Hnf4αos/Hnf4α duplex-mediated PGC1α suppression
by: Chaoqun Wang, et al.
Published: (2022-11-01)

SYNTHESIS OF RADIOPHARMACEUTICAL WITH RHENIUM-188 AND LIPIODOL
by: G. E. Kodina, et al.
Published: (2019-01-01)

Hepatocyte nuclear factor 4 a (HNF4α): A perspective in cancer
by: Ningxin Qu, et al.
Published: (2023-12-01)

The role of hepatocyte nuclear factor 4α (HNF4α) in tumorigenesis
by: Lei Sang, et al.
Published: (2022-09-01)

New Russian Trivalent Hepatitis B vaccine (Bubo<sup>®</sup>-Unigep): Phase I Clinical Study Results and Perspectives of Further Investigations Aiming Registration in Russia
by: R. Yo. Maksvitis, et al.
Published: (2020-01-01)

Pathophysiological aspects of liver damage in children with alpha-1-antitrypsin deficiency
by: G. V. Volynets, et al.
Published: (2020-03-01)

LOX-1 attenuates high glucose-induced autophagy via AMPK/HNF4α signaling in HLSECs
by: Qidang Duan, et al.
Published: (2022-12-01)

HNF4α Acts as Upstream Functional Regulator of Intestinal Wnt3 and Paneth Cell FateSummary
by: Christine Jones, et al.
Published: (2023-01-01)

Berberine Attenuated Proliferation, Invasion and Migration by Targeting the AMPK/HNF4α/WNT5A Pathway in Gastric Carcinoma
by: Qian Hu, et al.
Published: (2018-10-01)

HNF1A POU Domain Mutations Found in Japanese Liver Cancer Patients Cause Downregulation of <i>HNF4A</i> Promoter Activity with Possible Disruption in Transcription Networks
by: Effi Haque, et al.
Published: (2022-02-01)

Clinical, laboratory and coagulation system of blood feachers in patients with viral liver cirrhoses associated with virus hepatitis B, C and D
by: S. A. Bogushevich, et al.
Published: (2009-08-01)

LncRNA HOTAIR recruits SNAIL to inhibit the transcription of HNF4α and promote the viability, migration, invasion and EMT of colorectal cancer
by: Long Jin, et al.
Published: (2021-04-01)

Crosstalk of HNF4α with extracellular and intracellular signaling pathways in the regulation of hepatic metabolism of drugs and lipids
by: Hong Lu
Published: (2016-09-01)

Scalable Dual-Fluorescence Assay for Functional Interpretation of HNF-4α Missense Variants
by: Yiming Guo, et al.
Published: (2022-02-01)

Изменение ИК-спектров метаболитов энергетического обмена в крови крыс с гепатоцеллюлярной карциномой при воздействии гипертермии и апитоксина
by: Ol’ga V. Krasnikova, et al.
Published: (2024-02-01)

Exploring the potential application of liver organoids of mouse as developmental models upon Hnf4α knockout
by: ZHANG Zhiyu, CAO Jun, LIANG Junbo
Published: (2023-05-01)

Steroid receptor coactivator 3 inhibits hepatitis B virus gene expression through activating Akt signaling to prevent HNF4α nuclear translocation
by: Ming Li, et al.
Published: (2019-08-01)

The protein architecture and allosteric landscape of HNF4α
by: Fraydoon Rastinejad
Published: (2023-09-01)