A Biosensor Platform for Point-of-Care SARS-CoV-2 Screening
The COVID-19 pandemic remains a constant threat to human health, the economy, and social relations. Scientists around the world are constantly looking for new technological tools to deal with the pandemic. Such tools are the rapid virus detection tests, which are constantly evolving and optimizing....
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Biosensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6374/12/7/487 |
| _version_ | 1797433793680769024 |
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| author | Antonios Georgas Konstantinos Agiannis Vasiliki Papakosta Panagiotis Priftis Spyridon Angelopoulos Angelo Ferraro Evangelos Hristoforou |
| author_facet | Antonios Georgas Konstantinos Agiannis Vasiliki Papakosta Panagiotis Priftis Spyridon Angelopoulos Angelo Ferraro Evangelos Hristoforou |
| author_sort | Antonios Georgas |
| collection | DOAJ |
| description | The COVID-19 pandemic remains a constant threat to human health, the economy, and social relations. Scientists around the world are constantly looking for new technological tools to deal with the pandemic. Such tools are the rapid virus detection tests, which are constantly evolving and optimizing. This paper presents a biosensor platform for the rapid detection of spike protein both in laboratory conditions and in swab samples from hospitalized patients. It is a continuation and improvement of our previous work and consists of a microcontroller-based readout circuit, which measures the capacitance change generated in an interdigitated electrode transducer by the presence either of sole spike protein or the presence of SARS-CoV-2 particles in swab samples. The circuit efficiency is calibrated by its correlation with the capacitance measurement of an LCR (inductance (L), capacitance (C), and resistance (R)) meter. The test result is made available in less than 2 min through the microcontroller’s LCD (liquid-crystal display) screen, whereas at the same time, the collected data are sent wirelessly to a mobile application interface. The novelty of this research lies in the potential it offers for continuous and effective screening of SARS-CoV-2 patients, which is facilitated and enhanced, providing big data statistics of COVID-19 in terms of space and time. This device can be used by individuals for SARS-CoV-2 testing at home, by health professionals for patient monitoring, and by public health agencies for monitoring the spatio-temporal spread of the virus. |
| first_indexed | 2024-03-09T10:22:31Z |
| format | Article |
| id | doaj.art-ad6606e7fcca4787845c884dff789fae |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-09T10:22:31Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-ad6606e7fcca4787845c884dff789fae2023-12-01T21:56:57ZengMDPI AGBiosensors2079-63742022-07-0112748710.3390/bios12070487A Biosensor Platform for Point-of-Care SARS-CoV-2 ScreeningAntonios Georgas0Konstantinos Agiannis1Vasiliki Papakosta2Panagiotis Priftis3Spyridon Angelopoulos4Angelo Ferraro5Evangelos Hristoforou6School of Electrical and Computer Engineering, National Technical University of Athens, 15780 Athens, GreeceSchool of Electrical and Computer Engineering, National Technical University of Athens, 15780 Athens, GreeceSchool of Electrical and Computer Engineering, National Technical University of Athens, 15780 Athens, GreeceSchool of Electrical and Computer Engineering, National Technical University of Athens, 15780 Athens, GreeceSchool of Electrical and Computer Engineering, National Technical University of Athens, 15780 Athens, GreeceSchool of Electrical and Computer Engineering, National Technical University of Athens, 15780 Athens, GreeceSchool of Electrical and Computer Engineering, National Technical University of Athens, 15780 Athens, GreeceThe COVID-19 pandemic remains a constant threat to human health, the economy, and social relations. Scientists around the world are constantly looking for new technological tools to deal with the pandemic. Such tools are the rapid virus detection tests, which are constantly evolving and optimizing. This paper presents a biosensor platform for the rapid detection of spike protein both in laboratory conditions and in swab samples from hospitalized patients. It is a continuation and improvement of our previous work and consists of a microcontroller-based readout circuit, which measures the capacitance change generated in an interdigitated electrode transducer by the presence either of sole spike protein or the presence of SARS-CoV-2 particles in swab samples. The circuit efficiency is calibrated by its correlation with the capacitance measurement of an LCR (inductance (L), capacitance (C), and resistance (R)) meter. The test result is made available in less than 2 min through the microcontroller’s LCD (liquid-crystal display) screen, whereas at the same time, the collected data are sent wirelessly to a mobile application interface. The novelty of this research lies in the potential it offers for continuous and effective screening of SARS-CoV-2 patients, which is facilitated and enhanced, providing big data statistics of COVID-19 in terms of space and time. This device can be used by individuals for SARS-CoV-2 testing at home, by health professionals for patient monitoring, and by public health agencies for monitoring the spatio-temporal spread of the virus.https://www.mdpi.com/2079-6374/12/7/487virus monitoringSARS-CoV-2internet of thingsscreeningreadoutsmartphone |
| spellingShingle | Antonios Georgas Konstantinos Agiannis Vasiliki Papakosta Panagiotis Priftis Spyridon Angelopoulos Angelo Ferraro Evangelos Hristoforou A Biosensor Platform for Point-of-Care SARS-CoV-2 Screening Biosensors virus monitoring SARS-CoV-2 internet of things screening readout smartphone |
| title | A Biosensor Platform for Point-of-Care SARS-CoV-2 Screening |
| title_full | A Biosensor Platform for Point-of-Care SARS-CoV-2 Screening |
| title_fullStr | A Biosensor Platform for Point-of-Care SARS-CoV-2 Screening |
| title_full_unstemmed | A Biosensor Platform for Point-of-Care SARS-CoV-2 Screening |
| title_short | A Biosensor Platform for Point-of-Care SARS-CoV-2 Screening |
| title_sort | biosensor platform for point of care sars cov 2 screening |
| topic | virus monitoring SARS-CoV-2 internet of things screening readout smartphone |
| url | https://www.mdpi.com/2079-6374/12/7/487 |
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