CD95L Inhibition Impacts Gemcitabine-Mediated Effects and Non-Apoptotic Signaling of TNF-α and TRAIL in Pancreatic Tumor Cells

CD95L Inhibition Impacts Gemcitabine-Mediated Effects and Non-Apoptotic Signaling of TNF-α and TRAIL in Pancreatic Tumor Cells

Despite the potential apoptotic functions, the CD95/CD95L system can stimulate survival as well as pro-inflammatory signaling, particularly through the activation of NFκB. This holds true for the TNF/TNFR and the TRAIL/TRAILR systems. Thus, signaling pathways of these three death ligands converge, y...

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Bibliographic Details
Main Authors: Khalid Rashid, Christian Röder, Freya Goumas, Jan-Hendrik Egberts, Holger Kalthoff
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cancers
Subjects:
gemcitabine
death ligands
chemoresistance
PDAC
metastasis
Online Access:https://www.mdpi.com/2072-6694/13/21/5458

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