Spectrum of BCR-ABL mutations in Azerbaijanian imatinib-resistant patients with chronic myeloid leukemia

Spectrum of BCR-ABL mutations in Azerbaijanian imatinib-resistant patients with chronic myeloid leukemia

Objective: BCR-ABL1 kinase domain (KD) mutations can lead to resistance to first- and second-generation tyrosine kinase inhibitors (TKIs) in chronic myeloid leukemia (CML). Here, we present the first report of the spectrum of mutations in the BCR-ABL1 KD of CML patients from Azerbaijan.Materials and...

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Bibliographic Details
Main Authors: Aypara Hasanova, Chingiz Asadov, Nigar Karimova, Aytan Shirinova, Gunay Aliyeva, Zohra Alimirzoyeva
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Pathology and Oncology Research
Subjects:
chronic myeloid leukemia
mutation
tyrosine kinase inhibitor resistance
kinase domain
BCR-ABL
Online Access:https://www.por-journal.com/articles/10.3389/pore.2023.1611518/full

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