Molecular Link between DNA Damage Response and Microtubule Dynamics
Microtubules are major components of the cytoskeleton that play important roles in cellular processes such as intracellular transport and cell division. In recent years, it has become evident that microtubule networks play a role in genome maintenance during interphase. In this review, we highlight...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/13/6986 |
| _version_ | 1797479876582703104 |
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| author | Jung Min Kim |
| author_facet | Jung Min Kim |
| author_sort | Jung Min Kim |
| collection | DOAJ |
| description | Microtubules are major components of the cytoskeleton that play important roles in cellular processes such as intracellular transport and cell division. In recent years, it has become evident that microtubule networks play a role in genome maintenance during interphase. In this review, we highlight recent advances in understanding the role of microtubule dynamics in DNA damage response and repair. We first describe how DNA damage checkpoints regulate microtubule organization and stability. We then highlight how microtubule networks are involved in the nuclear remodeling following DNA damage, which leads to changes in chromosome organization. Lastly, we discuss how microtubule dynamics participate in the mobility of damaged DNA and promote consequent DNA repair. Together, the literature indicates the importance of microtubule dynamics in genome organization and stability during interphase. |
| first_indexed | 2024-03-09T21:52:06Z |
| format | Article |
| id | doaj.art-ad6772ee4cd049ccb20095ff5f1476a5 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T21:52:06Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ad6772ee4cd049ccb20095ff5f1476a52023-11-23T20:05:47ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-06-012313698610.3390/ijms23136986Molecular Link between DNA Damage Response and Microtubule DynamicsJung Min Kim0Department of Pharmacology, Chonnam National University Medical School, Gwangju 58128, KoreaMicrotubules are major components of the cytoskeleton that play important roles in cellular processes such as intracellular transport and cell division. In recent years, it has become evident that microtubule networks play a role in genome maintenance during interphase. In this review, we highlight recent advances in understanding the role of microtubule dynamics in DNA damage response and repair. We first describe how DNA damage checkpoints regulate microtubule organization and stability. We then highlight how microtubule networks are involved in the nuclear remodeling following DNA damage, which leads to changes in chromosome organization. Lastly, we discuss how microtubule dynamics participate in the mobility of damaged DNA and promote consequent DNA repair. Together, the literature indicates the importance of microtubule dynamics in genome organization and stability during interphase.https://www.mdpi.com/1422-0067/23/13/6986microtubulesDNA damage responsecentrosomenuclear reorganizationchromatin mobilityDNA repair |
| spellingShingle | Jung Min Kim Molecular Link between DNA Damage Response and Microtubule Dynamics International Journal of Molecular Sciences microtubules DNA damage response centrosome nuclear reorganization chromatin mobility DNA repair |
| title | Molecular Link between DNA Damage Response and Microtubule Dynamics |
| title_full | Molecular Link between DNA Damage Response and Microtubule Dynamics |
| title_fullStr | Molecular Link between DNA Damage Response and Microtubule Dynamics |
| title_full_unstemmed | Molecular Link between DNA Damage Response and Microtubule Dynamics |
| title_short | Molecular Link between DNA Damage Response and Microtubule Dynamics |
| title_sort | molecular link between dna damage response and microtubule dynamics |
| topic | microtubules DNA damage response centrosome nuclear reorganization chromatin mobility DNA repair |
| url | https://www.mdpi.com/1422-0067/23/13/6986 |
| work_keys_str_mv | AT jungminkim molecularlinkbetweendnadamageresponseandmicrotubuledynamics |