A Comparison of IgG Index and Oligoclonal Band in the Cerebrospinal Fluid for Differentiating between RRMS and NMOSD
As the oligoclonal band in the cerebrospinal fluid (CSF-OCB) in predicting relapsing-remitting multiple sclerosis (RRMS) is less sensitive in Asian populations than that in westerners, it remains elusive whether the IgG index could serve as an alternative. The purpose of this study was to compare th...
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MDPI AG
2021-12-01
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| Online Access: | https://www.mdpi.com/2076-3425/12/1/69 |
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| author | Bo Chen Dai-Shi Tian Bi-Tao Bu |
| author_facet | Bo Chen Dai-Shi Tian Bi-Tao Bu |
| author_sort | Bo Chen |
| collection | DOAJ |
| description | As the oligoclonal band in the cerebrospinal fluid (CSF-OCB) in predicting relapsing-remitting multiple sclerosis (RRMS) is less sensitive in Asian populations than that in westerners, it remains elusive whether the IgG index could serve as an alternative. The purpose of this study was to compare these two methods of differentiating between RRMS and neuromyelitis optica spectrum disorder (NMOSD) in Chinese patients. A total of 171 patients (81 RRMS and 90 NMOSD) were retrospectively recruited, of whom 82 (56 RRMS and 26 NMOSD) received the CSF-OCB testing additionally. When the onset age was ≤38.5 years, IgG index with the threshold of 0.67 had a significant agreement (<span style="font-variant: small-caps;">k</span> = 0.4, <i>p</i> < 0.001) with the diagnosis while CSF-OCB failed to discriminate (<span style="font-variant: small-caps;">k</span> = 0.1, <i>p</i> = 0.578). However, when the onset age was >38.5 years, both IgG index with the threshold of 0.8 and CSF-OCB were moderately consistent with the diagnosis (both <span style="font-variant: small-caps;">k</span> > 0.4, <i>p</i> < 0.05). In total, our optimized algorithm had the sensitivity, specificity, and predictive accuracy of 0.778, slightly outperforming the CSF-OCB model. Accordingly, a combination of the onset age and IgG index could serve as an alternative to CSF-OCB for differentiating between RRMS and NMOSD in Chinese patients. |
| first_indexed | 2024-03-10T01:49:22Z |
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| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T01:49:22Z |
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| spelling | doaj.art-ad6ec972afc14ec2864c2e6b0fcfe8bc2023-11-23T13:09:36ZengMDPI AGBrain Sciences2076-34252021-12-011216910.3390/brainsci12010069A Comparison of IgG Index and Oligoclonal Band in the Cerebrospinal Fluid for Differentiating between RRMS and NMOSDBo Chen0Dai-Shi Tian1Bi-Tao Bu2Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaAs the oligoclonal band in the cerebrospinal fluid (CSF-OCB) in predicting relapsing-remitting multiple sclerosis (RRMS) is less sensitive in Asian populations than that in westerners, it remains elusive whether the IgG index could serve as an alternative. The purpose of this study was to compare these two methods of differentiating between RRMS and neuromyelitis optica spectrum disorder (NMOSD) in Chinese patients. A total of 171 patients (81 RRMS and 90 NMOSD) were retrospectively recruited, of whom 82 (56 RRMS and 26 NMOSD) received the CSF-OCB testing additionally. When the onset age was ≤38.5 years, IgG index with the threshold of 0.67 had a significant agreement (<span style="font-variant: small-caps;">k</span> = 0.4, <i>p</i> < 0.001) with the diagnosis while CSF-OCB failed to discriminate (<span style="font-variant: small-caps;">k</span> = 0.1, <i>p</i> = 0.578). However, when the onset age was >38.5 years, both IgG index with the threshold of 0.8 and CSF-OCB were moderately consistent with the diagnosis (both <span style="font-variant: small-caps;">k</span> > 0.4, <i>p</i> < 0.05). In total, our optimized algorithm had the sensitivity, specificity, and predictive accuracy of 0.778, slightly outperforming the CSF-OCB model. Accordingly, a combination of the onset age and IgG index could serve as an alternative to CSF-OCB for differentiating between RRMS and NMOSD in Chinese patients.https://www.mdpi.com/2076-3425/12/1/69IgG indexoligoclonal bandrelapsing–remitting multiple sclerosisneuromyelitis optica spectrum disorderonset age |
| spellingShingle | Bo Chen Dai-Shi Tian Bi-Tao Bu A Comparison of IgG Index and Oligoclonal Band in the Cerebrospinal Fluid for Differentiating between RRMS and NMOSD Brain Sciences IgG index oligoclonal band relapsing–remitting multiple sclerosis neuromyelitis optica spectrum disorder onset age |
| title | A Comparison of IgG Index and Oligoclonal Band in the Cerebrospinal Fluid for Differentiating between RRMS and NMOSD |
| title_full | A Comparison of IgG Index and Oligoclonal Band in the Cerebrospinal Fluid for Differentiating between RRMS and NMOSD |
| title_fullStr | A Comparison of IgG Index and Oligoclonal Band in the Cerebrospinal Fluid for Differentiating between RRMS and NMOSD |
| title_full_unstemmed | A Comparison of IgG Index and Oligoclonal Band in the Cerebrospinal Fluid for Differentiating between RRMS and NMOSD |
| title_short | A Comparison of IgG Index and Oligoclonal Band in the Cerebrospinal Fluid for Differentiating between RRMS and NMOSD |
| title_sort | comparison of igg index and oligoclonal band in the cerebrospinal fluid for differentiating between rrms and nmosd |
| topic | IgG index oligoclonal band relapsing–remitting multiple sclerosis neuromyelitis optica spectrum disorder onset age |
| url | https://www.mdpi.com/2076-3425/12/1/69 |
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