Evaluation of C-reactive protein as predictor of adverse prognosis in acute myocardial infarction after percutaneous coronary intervention: A systematic review and meta-analysis from 18,715 individuals
BackgroundProper prognostic biomarker is of great importance for clinical decision-making in patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI). Although recently emerges plenty of novel inflammatory biomarkers, the canonical inflammatory mediator C-r...
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.1013501/full |
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| author | Shijie Liu Shijie Liu Hongcheng Jiang Hongcheng Jiang Menaka Dhuromsingh Menaka Dhuromsingh Lei Dai Lei Dai Yue Jiang Hesong Zeng Hesong Zeng |
| author_facet | Shijie Liu Shijie Liu Hongcheng Jiang Hongcheng Jiang Menaka Dhuromsingh Menaka Dhuromsingh Lei Dai Lei Dai Yue Jiang Hesong Zeng Hesong Zeng |
| author_sort | Shijie Liu |
| collection | DOAJ |
| description | BackgroundProper prognostic biomarker is of great importance for clinical decision-making in patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI). Although recently emerges plenty of novel inflammatory biomarkers, the canonical inflammatory mediator C-reactive protein still plays an important role in prognosing adverse post-infarction complications.MethodsPubMed, Embase, and Medline were systematically searched from the establishment of databases up to December 2021, conforming with standards set forth by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement.ResultsA total of 23 studies were eventually eligible for this meta-analysis, including 18,715 individuals. Our findings showed that elevated C-reactive protein (CRP) had a statistically significant superiority in predicting all-cause mortality (OR: 3.22, 95% CI: [2.71, 3.84], p < 0.00001), cardiovascular death (OR: 3.26, 95% CI: [2.30, 4.61], p < 0.00001), major adverse cardiovascular events (MACEs) (OR: 2.85, 95% CI [2.08, 3.90], p < 0.00001), heart failure (OR: 2.29, 95% CI: [1.48, 3.54], p = 0.0002), recurrent myocardial infarction (OR: 1.76, 95% CI: [1.28, 2.43], p < 0.001), and restenosis (OR: 1.71, 95% CI: [1.18, 2.47], p = 0.004). Subgroup analysis implies that CRP had better performance in predicting plenty of hospitalization and short-term (<12 months) adverse prognosis than long-term prognosis and Asian patients with elevated CRP were under more risk in adverse prognosis after PCI than Europeans.ConclusionOur meta-analysis suggests that CRP is a prospective predictor of the prognosis in patients with AMI undergoing PCI, especially in hospitalization and short-term and in the Asian group. |
| first_indexed | 2024-04-13T10:37:22Z |
| format | Article |
| id | doaj.art-ad6edac98f4242579602246aebefbcb8 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-13T10:37:22Z |
| publishDate | 2022-11-01 |
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| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-ad6edac98f4242579602246aebefbcb82022-12-22T02:50:01ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-11-01910.3389/fcvm.2022.10135011013501Evaluation of C-reactive protein as predictor of adverse prognosis in acute myocardial infarction after percutaneous coronary intervention: A systematic review and meta-analysis from 18,715 individualsShijie Liu0Shijie Liu1Hongcheng Jiang2Hongcheng Jiang3Menaka Dhuromsingh4Menaka Dhuromsingh5Lei Dai6Lei Dai7Yue Jiang8Hesong Zeng9Hesong Zeng10Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, ChinaHubei Provincial Engineering Research Center of Vascular Interventional Therapy, Wuhan, Hubei, ChinaDivision of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, ChinaHubei Provincial Engineering Research Center of Vascular Interventional Therapy, Wuhan, Hubei, ChinaDivision of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, ChinaHubei Provincial Engineering Research Center of Vascular Interventional Therapy, Wuhan, Hubei, ChinaDivision of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, ChinaHubei Provincial Engineering Research Center of Vascular Interventional Therapy, Wuhan, Hubei, ChinaDivision of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, ChinaDivision of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, ChinaHubei Provincial Engineering Research Center of Vascular Interventional Therapy, Wuhan, Hubei, ChinaBackgroundProper prognostic biomarker is of great importance for clinical decision-making in patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI). Although recently emerges plenty of novel inflammatory biomarkers, the canonical inflammatory mediator C-reactive protein still plays an important role in prognosing adverse post-infarction complications.MethodsPubMed, Embase, and Medline were systematically searched from the establishment of databases up to December 2021, conforming with standards set forth by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement.ResultsA total of 23 studies were eventually eligible for this meta-analysis, including 18,715 individuals. Our findings showed that elevated C-reactive protein (CRP) had a statistically significant superiority in predicting all-cause mortality (OR: 3.22, 95% CI: [2.71, 3.84], p < 0.00001), cardiovascular death (OR: 3.26, 95% CI: [2.30, 4.61], p < 0.00001), major adverse cardiovascular events (MACEs) (OR: 2.85, 95% CI [2.08, 3.90], p < 0.00001), heart failure (OR: 2.29, 95% CI: [1.48, 3.54], p = 0.0002), recurrent myocardial infarction (OR: 1.76, 95% CI: [1.28, 2.43], p < 0.001), and restenosis (OR: 1.71, 95% CI: [1.18, 2.47], p = 0.004). Subgroup analysis implies that CRP had better performance in predicting plenty of hospitalization and short-term (<12 months) adverse prognosis than long-term prognosis and Asian patients with elevated CRP were under more risk in adverse prognosis after PCI than Europeans.ConclusionOur meta-analysis suggests that CRP is a prospective predictor of the prognosis in patients with AMI undergoing PCI, especially in hospitalization and short-term and in the Asian group.https://www.frontiersin.org/articles/10.3389/fcvm.2022.1013501/fullacute myocardial infarctionpercutaneous coronary intervention (PCI)C-reactive protein (CRP)adverse prognosisinflammatory/anti-inflammatory factorscoronary arterial disease |
| spellingShingle | Shijie Liu Shijie Liu Hongcheng Jiang Hongcheng Jiang Menaka Dhuromsingh Menaka Dhuromsingh Lei Dai Lei Dai Yue Jiang Hesong Zeng Hesong Zeng Evaluation of C-reactive protein as predictor of adverse prognosis in acute myocardial infarction after percutaneous coronary intervention: A systematic review and meta-analysis from 18,715 individuals Frontiers in Cardiovascular Medicine acute myocardial infarction percutaneous coronary intervention (PCI) C-reactive protein (CRP) adverse prognosis inflammatory/anti-inflammatory factors coronary arterial disease |
| title | Evaluation of C-reactive protein as predictor of adverse prognosis in acute myocardial infarction after percutaneous coronary intervention: A systematic review and meta-analysis from 18,715 individuals |
| title_full | Evaluation of C-reactive protein as predictor of adverse prognosis in acute myocardial infarction after percutaneous coronary intervention: A systematic review and meta-analysis from 18,715 individuals |
| title_fullStr | Evaluation of C-reactive protein as predictor of adverse prognosis in acute myocardial infarction after percutaneous coronary intervention: A systematic review and meta-analysis from 18,715 individuals |
| title_full_unstemmed | Evaluation of C-reactive protein as predictor of adverse prognosis in acute myocardial infarction after percutaneous coronary intervention: A systematic review and meta-analysis from 18,715 individuals |
| title_short | Evaluation of C-reactive protein as predictor of adverse prognosis in acute myocardial infarction after percutaneous coronary intervention: A systematic review and meta-analysis from 18,715 individuals |
| title_sort | evaluation of c reactive protein as predictor of adverse prognosis in acute myocardial infarction after percutaneous coronary intervention a systematic review and meta analysis from 18 715 individuals |
| topic | acute myocardial infarction percutaneous coronary intervention (PCI) C-reactive protein (CRP) adverse prognosis inflammatory/anti-inflammatory factors coronary arterial disease |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.1013501/full |
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