The Pharmacological Efficacy of Baicalin in Inflammatory Diseases
Baicalin is one of the most abundant flavonoids found in the dried roots of <i>Scutellaria baicalensis</i> Georgi (SBG) belonging to the genus <i>Scutellaria</i>. While baicalin is demonstrated to have anti-inflammatory, antiviral, antitumor, antibacterial, anticonvulsant, an...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/11/9317 |
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| author | Yongqiang Wen Yazhou Wang Chenxu Zhao Baoyu Zhao Jianguo Wang |
| author_facet | Yongqiang Wen Yazhou Wang Chenxu Zhao Baoyu Zhao Jianguo Wang |
| author_sort | Yongqiang Wen |
| collection | DOAJ |
| description | Baicalin is one of the most abundant flavonoids found in the dried roots of <i>Scutellaria baicalensis</i> Georgi (SBG) belonging to the genus <i>Scutellaria</i>. While baicalin is demonstrated to have anti-inflammatory, antiviral, antitumor, antibacterial, anticonvulsant, antioxidant, hepatoprotective, and neuroprotective effects, its low hydrophilicity and lipophilicity limit the bioavailability and pharmacological functions. Therefore, an in-depth study of baicalin’s bioavailability and pharmacokinetics contributes to laying the theoretical foundation for applied research in disease treatment. In this view, the physicochemical properties and anti-inflammatory activity of baicalin are summarized in terms of bioavailability, drug interaction, and inflammatory conditions. |
| first_indexed | 2024-03-11T03:05:55Z |
| format | Article |
| id | doaj.art-ad70186ebe3949e08a10c273f980cadd |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T03:05:55Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ad70186ebe3949e08a10c273f980cadd2023-11-18T07:57:22ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-05-012411931710.3390/ijms24119317The Pharmacological Efficacy of Baicalin in Inflammatory DiseasesYongqiang Wen0Yazhou Wang1Chenxu Zhao2Baoyu Zhao3Jianguo Wang4College of Veterinary Medicine, Northwest A&F University, Xianyang 712100, ChinaCollege of Veterinary Medicine, Northwest A&F University, Xianyang 712100, ChinaCollege of Veterinary Medicine, Northwest A&F University, Xianyang 712100, ChinaCollege of Veterinary Medicine, Northwest A&F University, Xianyang 712100, ChinaCollege of Veterinary Medicine, Northwest A&F University, Xianyang 712100, ChinaBaicalin is one of the most abundant flavonoids found in the dried roots of <i>Scutellaria baicalensis</i> Georgi (SBG) belonging to the genus <i>Scutellaria</i>. While baicalin is demonstrated to have anti-inflammatory, antiviral, antitumor, antibacterial, anticonvulsant, antioxidant, hepatoprotective, and neuroprotective effects, its low hydrophilicity and lipophilicity limit the bioavailability and pharmacological functions. Therefore, an in-depth study of baicalin’s bioavailability and pharmacokinetics contributes to laying the theoretical foundation for applied research in disease treatment. In this view, the physicochemical properties and anti-inflammatory activity of baicalin are summarized in terms of bioavailability, drug interaction, and inflammatory conditions.https://www.mdpi.com/1422-0067/24/11/9317baicalinbioavailabilitydrug interactionanti-inflammatory activitypharmacokinetics |
| spellingShingle | Yongqiang Wen Yazhou Wang Chenxu Zhao Baoyu Zhao Jianguo Wang The Pharmacological Efficacy of Baicalin in Inflammatory Diseases International Journal of Molecular Sciences baicalin bioavailability drug interaction anti-inflammatory activity pharmacokinetics |
| title | The Pharmacological Efficacy of Baicalin in Inflammatory Diseases |
| title_full | The Pharmacological Efficacy of Baicalin in Inflammatory Diseases |
| title_fullStr | The Pharmacological Efficacy of Baicalin in Inflammatory Diseases |
| title_full_unstemmed | The Pharmacological Efficacy of Baicalin in Inflammatory Diseases |
| title_short | The Pharmacological Efficacy of Baicalin in Inflammatory Diseases |
| title_sort | pharmacological efficacy of baicalin in inflammatory diseases |
| topic | baicalin bioavailability drug interaction anti-inflammatory activity pharmacokinetics |
| url | https://www.mdpi.com/1422-0067/24/11/9317 |
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