Human disordered charged biased proteins: from the proteome to the druggome
The human disordered charged biased proteins (HDCBPs) are involved in complex diseases. The HDCBP-disease network constructed in our earlier showed that HDCBPs share many diseases. Therefore, they are attractive therapeutic targets for drug discovery. In this study, we explore the associations betwe...
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| Format: | Article |
| Language: | English |
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International Academy of Ecology and Environmental Sciences
2024-03-01
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| Series: | Network Biology |
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| Online Access: | http://www.iaees.org/publications/journals/nb/articles/2024-14(1)/human-disordered-charged-biased-proteins.pdf |
| _version_ | 1797304020528791552 |
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| author | Mouna Choura |
| author_facet | Mouna Choura |
| author_sort | Mouna Choura |
| collection | DOAJ |
| description | The human disordered charged biased proteins (HDCBPs) are involved in complex diseases. The HDCBP-disease network constructed in our earlier showed that HDCBPs share many diseases. Therefore, they are attractive therapeutic targets for drug discovery. In this study, we explore the associations between (HDCBPs), the related diseases, and the drugs. The results show that 20% and 14% of HDCBPs are listed in DRUGBANK and ChemDB respectively. The elaborated HDCBP-Drug-Disease network revealed that most of the therapeutic area indications included cancer, neoplasm, lymphoma, cardiovascular, respiratory and skin diseases. The constructed HDCBP-Drug-Disease network may improve our understanding of complex diseases and related drugs. Moreover, such a network could suggest opportunities of drug repurposing for which efficacy should be investigated in functional validation studies.
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| first_indexed | 2024-03-08T00:03:17Z |
| format | Article |
| id | doaj.art-ad7067ac3952494f9a8d8dea9c6503e5 |
| institution | Directory Open Access Journal |
| issn | 2220-8879 |
| language | English |
| last_indexed | 2024-03-08T00:03:17Z |
| publishDate | 2024-03-01 |
| publisher | International Academy of Ecology and Environmental Sciences |
| record_format | Article |
| series | Network Biology |
| spelling | doaj.art-ad7067ac3952494f9a8d8dea9c6503e52024-02-18T01:23:59ZengInternational Academy of Ecology and Environmental SciencesNetwork Biology2220-88792024-03-011412024Human disordered charged biased proteins: from the proteome to the druggomeMouna Choura0Laboratory of Biotechnology and Plant Improvement, Center of Biotechnology of Sfax, University of Sfax, Route Sidi Mansour, Po Box 1177, 3018 Sfax, TunisiaThe human disordered charged biased proteins (HDCBPs) are involved in complex diseases. The HDCBP-disease network constructed in our earlier showed that HDCBPs share many diseases. Therefore, they are attractive therapeutic targets for drug discovery. In this study, we explore the associations between (HDCBPs), the related diseases, and the drugs. The results show that 20% and 14% of HDCBPs are listed in DRUGBANK and ChemDB respectively. The elaborated HDCBP-Drug-Disease network revealed that most of the therapeutic area indications included cancer, neoplasm, lymphoma, cardiovascular, respiratory and skin diseases. The constructed HDCBP-Drug-Disease network may improve our understanding of complex diseases and related drugs. Moreover, such a network could suggest opportunities of drug repurposing for which efficacy should be investigated in functional validation studies. http://www.iaees.org/publications/journals/nb/articles/2024-14(1)/human-disordered-charged-biased-proteins.pdfcharged biased proteinsdiseasesdatabasesdrugsnetworktherapeutic targets |
| spellingShingle | Mouna Choura Human disordered charged biased proteins: from the proteome to the druggome Network Biology charged biased proteins diseases databases drugs network therapeutic targets |
| title | Human disordered charged biased proteins: from the proteome to the druggome |
| title_full | Human disordered charged biased proteins: from the proteome to the druggome |
| title_fullStr | Human disordered charged biased proteins: from the proteome to the druggome |
| title_full_unstemmed | Human disordered charged biased proteins: from the proteome to the druggome |
| title_short | Human disordered charged biased proteins: from the proteome to the druggome |
| title_sort | human disordered charged biased proteins from the proteome to the druggome |
| topic | charged biased proteins diseases databases drugs network therapeutic targets |
| url | http://www.iaees.org/publications/journals/nb/articles/2024-14(1)/human-disordered-charged-biased-proteins.pdf |
| work_keys_str_mv | AT mounachoura humandisorderedchargedbiasedproteinsfromtheproteometothedruggome |