Molecular Mechanisms of Resistance to Ionizing Radiation in <i>S. cerevisiae</i> and Its Relationship with Aging, Oxidative Stress, and Antioxidant Activity
The repair of the damage produced to the genome and proteome by the action of ionizing radiation, oxidizing agents, and during aging is important to maintain cellular homeostasis. Many of the metabolic pathways influence multiple processes. In this way, this work aims to study the relationship betwe...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/12/9/1690 |
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| author | Alejandro González-Vidal Silvia Mercado-Sáenz Antonio M. Burgos-Molina Juan C. Alamilla-Presuel Miguel Alcaraz Francisco Sendra-Portero Miguel J. Ruiz-Gómez |
| author_facet | Alejandro González-Vidal Silvia Mercado-Sáenz Antonio M. Burgos-Molina Juan C. Alamilla-Presuel Miguel Alcaraz Francisco Sendra-Portero Miguel J. Ruiz-Gómez |
| author_sort | Alejandro González-Vidal |
| collection | DOAJ |
| description | The repair of the damage produced to the genome and proteome by the action of ionizing radiation, oxidizing agents, and during aging is important to maintain cellular homeostasis. Many of the metabolic pathways influence multiple processes. In this way, this work aims to study the relationship between resistance/response to ionizing radiation, cellular aging, and the response mechanisms to oxidative stress, free radicals, reactive oxygen species (ROS), and antioxidant activity in the yeast <i>S. cerevisiae</i>. Systems biology allows us to use tools that reveal the molecular mechanisms common to different cellular response phenomena. The results found indicate that homologous recombination, non-homologous end joining, and base excision repair pathways are the most important common processes necessary to maintain cellular homeostasis. The metabolic routes of longevity regulation are those that jointly contribute to the three phenomena studied. This study proposes eleven common biomarkers for response/resistance to ionizing radiation and aging (EXO1, MEC1, MRE11, RAD27, RAD50, RAD51, RAD52, RAD55, RAD9, SGS1, YKU70) and two biomarkers for response/resistance to radiation and oxidative stress, free radicals, ROS, and antioxidant activity (NTG1, OGG1). In addition, it is important to highlight that the HSP104 protein could be a good biomarker common to the three phenomena studied. |
| first_indexed | 2024-03-10T23:06:44Z |
| format | Article |
| id | doaj.art-ad70ccfc5f524c6eac1c8e11a5d71376 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T23:06:44Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-ad70ccfc5f524c6eac1c8e11a5d713762023-11-19T09:19:04ZengMDPI AGAntioxidants2076-39212023-08-01129169010.3390/antiox12091690Molecular Mechanisms of Resistance to Ionizing Radiation in <i>S. cerevisiae</i> and Its Relationship with Aging, Oxidative Stress, and Antioxidant ActivityAlejandro González-Vidal0Silvia Mercado-Sáenz1Antonio M. Burgos-Molina2Juan C. Alamilla-Presuel3Miguel Alcaraz4Francisco Sendra-Portero5Miguel J. Ruiz-Gómez6Departamento de Radiología y Medicina Física, Facultad de Medicina, Universidad de Málaga, 29010 Málaga, SpainInstituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina (IBIMA Plataforma BIONAND), Parque Tecnológico de Andalucía (PTA), 29590 Málaga, SpainInstituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina (IBIMA Plataforma BIONAND), Parque Tecnológico de Andalucía (PTA), 29590 Málaga, SpainDepartamento de Radiología y Medicina Física, Facultad de Medicina, Universidad de Málaga, 29010 Málaga, SpainDepartamento de Radiología y Medicina Física, Facultad de Medicina, Universidad de Murcia, 30100 Murcia, SpainDepartamento de Radiología y Medicina Física, Facultad de Medicina, Universidad de Málaga, 29010 Málaga, SpainDepartamento de Radiología y Medicina Física, Facultad de Medicina, Universidad de Málaga, 29010 Málaga, SpainThe repair of the damage produced to the genome and proteome by the action of ionizing radiation, oxidizing agents, and during aging is important to maintain cellular homeostasis. Many of the metabolic pathways influence multiple processes. In this way, this work aims to study the relationship between resistance/response to ionizing radiation, cellular aging, and the response mechanisms to oxidative stress, free radicals, reactive oxygen species (ROS), and antioxidant activity in the yeast <i>S. cerevisiae</i>. Systems biology allows us to use tools that reveal the molecular mechanisms common to different cellular response phenomena. The results found indicate that homologous recombination, non-homologous end joining, and base excision repair pathways are the most important common processes necessary to maintain cellular homeostasis. The metabolic routes of longevity regulation are those that jointly contribute to the three phenomena studied. This study proposes eleven common biomarkers for response/resistance to ionizing radiation and aging (EXO1, MEC1, MRE11, RAD27, RAD50, RAD51, RAD52, RAD55, RAD9, SGS1, YKU70) and two biomarkers for response/resistance to radiation and oxidative stress, free radicals, ROS, and antioxidant activity (NTG1, OGG1). In addition, it is important to highlight that the HSP104 protein could be a good biomarker common to the three phenomena studied.https://www.mdpi.com/2076-3921/12/9/1690ionizing radiationagingoxidative stressfree radicalsreactive oxygen speciesROS |
| spellingShingle | Alejandro González-Vidal Silvia Mercado-Sáenz Antonio M. Burgos-Molina Juan C. Alamilla-Presuel Miguel Alcaraz Francisco Sendra-Portero Miguel J. Ruiz-Gómez Molecular Mechanisms of Resistance to Ionizing Radiation in <i>S. cerevisiae</i> and Its Relationship with Aging, Oxidative Stress, and Antioxidant Activity Antioxidants ionizing radiation aging oxidative stress free radicals reactive oxygen species ROS |
| title | Molecular Mechanisms of Resistance to Ionizing Radiation in <i>S. cerevisiae</i> and Its Relationship with Aging, Oxidative Stress, and Antioxidant Activity |
| title_full | Molecular Mechanisms of Resistance to Ionizing Radiation in <i>S. cerevisiae</i> and Its Relationship with Aging, Oxidative Stress, and Antioxidant Activity |
| title_fullStr | Molecular Mechanisms of Resistance to Ionizing Radiation in <i>S. cerevisiae</i> and Its Relationship with Aging, Oxidative Stress, and Antioxidant Activity |
| title_full_unstemmed | Molecular Mechanisms of Resistance to Ionizing Radiation in <i>S. cerevisiae</i> and Its Relationship with Aging, Oxidative Stress, and Antioxidant Activity |
| title_short | Molecular Mechanisms of Resistance to Ionizing Radiation in <i>S. cerevisiae</i> and Its Relationship with Aging, Oxidative Stress, and Antioxidant Activity |
| title_sort | molecular mechanisms of resistance to ionizing radiation in i s cerevisiae i and its relationship with aging oxidative stress and antioxidant activity |
| topic | ionizing radiation aging oxidative stress free radicals reactive oxygen species ROS |
| url | https://www.mdpi.com/2076-3921/12/9/1690 |
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