RBPJ Controls Development of Pathogenic Th17 Cells by Regulating IL-23 Receptor Expression

RBPJ Controls Development of Pathogenic Th17 Cells by Regulating IL-23 Receptor Expression

Interleukin-17 (IL-17)-producing helper T cells (Th17 cells) play an important role in autoimmune diseases. However, not all Th17 cells induce tissue inflammation or autoimmunity. Th17 cells require IL-23 receptor (IL-23R) signaling to become pathogenic. The transcriptional mechanisms controlling th...

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Podrobná bibliografie
Hlavní autoři: Gerd Meyer zu Horste, Chuan Wu, Chao Wang, Le Cong, Mathias Pawlak, Youjin Lee, Wassim Elyaman, Sheng Xiao, Aviv Regev, Vijay K. Kuchroo
Médium: Článek
Jazyk:English
Vydáno: Elsevier 2016-07-01
Edice:Cell Reports
Témata:
Th17 cells
pathogenicity
IL-23R
RBPJ
Notch
On-line přístup:http://www.sciencedirect.com/science/article/pii/S221112471630701X

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