Intracellular proton access in a Cl(-)/H(+) antiporter.
Chloride-transporting membrane proteins of the CLC family appear in two distinct mechanistic flavors: H(+)-gated Cl(-) channels and Cl(-)/H(+) antiporters. Transmembrane H(+) movement is an essential feature of both types of CLC. X-ray crystal structures of CLC antiporters show the Cl(-) ion pathway...
Main Authors: | Hyun-Ho Lim, Tania Shane, Christopher Miller |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
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Series: | PLoS Biology |
Online Access: | http://europepmc.org/articles/PMC3519907?pdf=render |
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