Let-7 as a Promising Target in Aging and Aging-Related Diseases: A Promise or a Pledge
The abnormal regulation and expression of microRNA (miRNA) are closely related to the aging process and the occurrence and development of aging-related diseases. Lethal-7 (let-7) was discovered in <i>Caenorhabditis elegans</i> (<i>C. elegans</i>) and plays an important role i...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/12/8/1070 |
| _version_ | 1797432448337838080 |
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| author | Ya Wang Juanjuan Zhao Shipeng Chen Dongmei Li Jing Yang Xu Zhao Ming Qin Mengmeng Guo Chao Chen Zhixu He Ya Zhou Lin Xu |
| author_facet | Ya Wang Juanjuan Zhao Shipeng Chen Dongmei Li Jing Yang Xu Zhao Ming Qin Mengmeng Guo Chao Chen Zhixu He Ya Zhou Lin Xu |
| author_sort | Ya Wang |
| collection | DOAJ |
| description | The abnormal regulation and expression of microRNA (miRNA) are closely related to the aging process and the occurrence and development of aging-related diseases. Lethal-7 (let-7) was discovered in <i>Caenorhabditis elegans</i> (<i>C. elegans</i>) and plays an important role in development by regulating cell fate regulators. Accumulating evidence has shown that let-7 is elevated in aging tissues and participates in multiple pathways that regulate the aging process, including affecting tissue stem cell function, body metabolism, and various aging-related diseases (ARDs). Moreover, recent studies have found that let-7 plays an important role in the senescence of B cells, suggesting that let-7 may also participate in the aging process by regulating immune function. Therefore, these studies show the diversity and complexity of let-7 expression and regulatory functions during aging. In this review, we provide a detailed overview of let-7 expression regulation as well as its role in different tissue aging and aging-related diseases, which may provide new ideas for enriching the complex expression regulation mechanism and pathobiological function of let-7 in aging and related diseases and ultimately provide help for the development of new therapeutic strategies. |
| first_indexed | 2024-03-09T10:00:39Z |
| format | Article |
| id | doaj.art-ad77ffce25c54d949af4c3836faaff54 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T10:00:39Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-ad77ffce25c54d949af4c3836faaff542023-12-01T23:28:56ZengMDPI AGBiomolecules2218-273X2022-08-01128107010.3390/biom12081070Let-7 as a Promising Target in Aging and Aging-Related Diseases: A Promise or a PledgeYa Wang0Juanjuan Zhao1Shipeng Chen2Dongmei Li3Jing Yang4Xu Zhao5Ming Qin6Mengmeng Guo7Chao Chen8Zhixu He9Ya Zhou10Lin Xu11Special Key Laboratory of Gene Detection and Therapy & Base for Talents in Biotherapy of Guizhou Province, Zunyi 563000, ChinaSpecial Key Laboratory of Gene Detection and Therapy & Base for Talents in Biotherapy of Guizhou Province, Zunyi 563000, ChinaSpecial Key Laboratory of Gene Detection and Therapy & Base for Talents in Biotherapy of Guizhou Province, Zunyi 563000, ChinaSpecial Key Laboratory of Gene Detection and Therapy & Base for Talents in Biotherapy of Guizhou Province, Zunyi 563000, ChinaSpecial Key Laboratory of Gene Detection and Therapy & Base for Talents in Biotherapy of Guizhou Province, Zunyi 563000, ChinaSpecial Key Laboratory of Gene Detection and Therapy & Base for Talents in Biotherapy of Guizhou Province, Zunyi 563000, ChinaSpecial Key Laboratory of Gene Detection and Therapy & Base for Talents in Biotherapy of Guizhou Province, Zunyi 563000, ChinaSpecial Key Laboratory of Gene Detection and Therapy & Base for Talents in Biotherapy of Guizhou Province, Zunyi 563000, ChinaSpecial Key Laboratory of Gene Detection and Therapy & Base for Talents in Biotherapy of Guizhou Province, Zunyi 563000, ChinaThe Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University, Zunyi 563000, ChinaSpecial Key Laboratory of Gene Detection and Therapy & Base for Talents in Biotherapy of Guizhou Province, Zunyi 563000, ChinaSpecial Key Laboratory of Gene Detection and Therapy & Base for Talents in Biotherapy of Guizhou Province, Zunyi 563000, ChinaThe abnormal regulation and expression of microRNA (miRNA) are closely related to the aging process and the occurrence and development of aging-related diseases. Lethal-7 (let-7) was discovered in <i>Caenorhabditis elegans</i> (<i>C. elegans</i>) and plays an important role in development by regulating cell fate regulators. Accumulating evidence has shown that let-7 is elevated in aging tissues and participates in multiple pathways that regulate the aging process, including affecting tissue stem cell function, body metabolism, and various aging-related diseases (ARDs). Moreover, recent studies have found that let-7 plays an important role in the senescence of B cells, suggesting that let-7 may also participate in the aging process by regulating immune function. Therefore, these studies show the diversity and complexity of let-7 expression and regulatory functions during aging. In this review, we provide a detailed overview of let-7 expression regulation as well as its role in different tissue aging and aging-related diseases, which may provide new ideas for enriching the complex expression regulation mechanism and pathobiological function of let-7 in aging and related diseases and ultimately provide help for the development of new therapeutic strategies.https://www.mdpi.com/2218-273X/12/8/1070miRNAlet-7regulationagingaging-related diseases |
| spellingShingle | Ya Wang Juanjuan Zhao Shipeng Chen Dongmei Li Jing Yang Xu Zhao Ming Qin Mengmeng Guo Chao Chen Zhixu He Ya Zhou Lin Xu Let-7 as a Promising Target in Aging and Aging-Related Diseases: A Promise or a Pledge Biomolecules miRNA let-7 regulation aging aging-related diseases |
| title | Let-7 as a Promising Target in Aging and Aging-Related Diseases: A Promise or a Pledge |
| title_full | Let-7 as a Promising Target in Aging and Aging-Related Diseases: A Promise or a Pledge |
| title_fullStr | Let-7 as a Promising Target in Aging and Aging-Related Diseases: A Promise or a Pledge |
| title_full_unstemmed | Let-7 as a Promising Target in Aging and Aging-Related Diseases: A Promise or a Pledge |
| title_short | Let-7 as a Promising Target in Aging and Aging-Related Diseases: A Promise or a Pledge |
| title_sort | let 7 as a promising target in aging and aging related diseases a promise or a pledge |
| topic | miRNA let-7 regulation aging aging-related diseases |
| url | https://www.mdpi.com/2218-273X/12/8/1070 |
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