Air pollution associate with advanced hepatic fibrosis among patients with chronic liver disease
Abstract We aimed to investigate the association between air pollution and advanced fibrosis among patients with metabolic associated fatty liver disease (MAFLD) and chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. A total of 1376 participants who were seropositive for HBV sur...
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-03-01
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| Series: | Kaohsiung Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/kjm2.12781 |
| _version_ | 1797265475830284288 |
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| author | Tyng‐Yuan Jang Chi‐Chang Ho Po‐Cheng Liang Chih‐Da Wu Yu‐Ju Wei Pei‐Chien Tsai Po‐Yao Hsu Ming‐Yen Hsieh Yi‐Hung Lin Meng‐Hsuan Hsieh Chih‐Wen Wang Jeng‐Fu Yang Ming‐Lun Yeh Chung‐Feng Huang Wan‐Long Chuang Jee‐Fu Huang Ya‐Yun Cheng Chia‐Yen Dai Pau‐Chung Chen Ming‐Lung Yu |
| author_facet | Tyng‐Yuan Jang Chi‐Chang Ho Po‐Cheng Liang Chih‐Da Wu Yu‐Ju Wei Pei‐Chien Tsai Po‐Yao Hsu Ming‐Yen Hsieh Yi‐Hung Lin Meng‐Hsuan Hsieh Chih‐Wen Wang Jeng‐Fu Yang Ming‐Lun Yeh Chung‐Feng Huang Wan‐Long Chuang Jee‐Fu Huang Ya‐Yun Cheng Chia‐Yen Dai Pau‐Chung Chen Ming‐Lung Yu |
| author_sort | Tyng‐Yuan Jang |
| collection | DOAJ |
| description | Abstract We aimed to investigate the association between air pollution and advanced fibrosis among patients with metabolic associated fatty liver disease (MAFLD) and chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. A total of 1376 participants who were seropositive for HBV surface antigen (HBsAg) or antibodies to HCV (anti‐HCV) or had abnormal liver function in a community screening program from 2019 to 2021 were enrolled for the assessment of liver fibrosis using transient elastography. Daily estimates of air pollutants (particulate matter ≤2.5 μm in diameter [PM2.5], nitrogen dioxide [NO2], ozone [O3] and benzene) were aggregated into mean estimates for the previous year based on the date of enrolment. Of the 1376 participants, 767 (52.8%) and 187 (13.6) had MAFLD and advanced fibrosis, respectively. A logistic regression analysis revealed that the factors associated with advanced liver fibrosis were HCV viremia (odds ratio [OR], 3.13; 95% confidence interval [CI], 2.05–4.77; p < 0.001), smoking (OR, 1.79; 95% CI, 1.16–2.74; p = 0.01), age (OR, 1.04; 95% CI, 1.02–1.05; p < 0.001) and PM2.5 (OR, 1.10; 95% CI, 1.05–1.16; p < 0.001). Linear regression analysis revealed that LSM was independently correlated with PM2.5 (β: 0.134; 95% CI: 0.025, 0.243; p = 0.02). There was a dose‐dependent relationship between different fibrotic stages and the PM2.5 level (the PM2.5 level in patients with fibrotic stages 0, 1–2 and 3–4: 27.9, 28.4, and 29.3 μg/m3, respectively; trend p < 0.001). Exposure to PM2.5, as well as HBV and HCV infections, is associated with advanced liver fibrosis in patients with MAFLD. There was a dose‐dependent correlation between PM2.5 levels and the severity of hepatic fibrosis. |
| first_indexed | 2024-04-25T00:45:24Z |
| format | Article |
| id | doaj.art-ad783073b7624fa8acbbdc3f0e6d7211 |
| institution | Directory Open Access Journal |
| issn | 1607-551X 2410-8650 |
| language | English |
| last_indexed | 2024-04-25T00:45:24Z |
| publishDate | 2024-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Kaohsiung Journal of Medical Sciences |
| spelling | doaj.art-ad783073b7624fa8acbbdc3f0e6d72112024-03-12T05:57:10ZengWileyKaohsiung Journal of Medical Sciences1607-551X2410-86502024-03-0140330431410.1002/kjm2.12781Air pollution associate with advanced hepatic fibrosis among patients with chronic liver diseaseTyng‐Yuan Jang0Chi‐Chang Ho1Po‐Cheng Liang2Chih‐Da Wu3Yu‐Ju Wei4Pei‐Chien Tsai5Po‐Yao Hsu6Ming‐Yen Hsieh7Yi‐Hung Lin8Meng‐Hsuan Hsieh9Chih‐Wen Wang10Jeng‐Fu Yang11Ming‐Lun Yeh12Chung‐Feng Huang13Wan‐Long Chuang14Jee‐Fu Huang15Ya‐Yun Cheng16Chia‐Yen Dai17Pau‐Chung Chen18Ming‐Lung Yu19Ph.D. Program in Environmental and Occupational Medicine, College of Medicine Kaohsiung Medical University and National Health Research Institutes Kaohsiung TaiwanInstitute of Environmental and Occupational Health Sciences National Taiwan University Taipei TaiwanHepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung TaiwanDepartment of Geomatics National Cheng Kung University Tainan TaiwanHepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung TaiwanHepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung TaiwanHepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung TaiwanHepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung TaiwanHepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung TaiwanHepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung TaiwanHepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung TaiwanHepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung TaiwanHepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung TaiwanHepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung TaiwanHepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung TaiwanHepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung TaiwanSchool of Medicine and Doctoral Program of Clinical and Experimental Medicine, College of Medicine and Center of Excellence for Metabolic Associated Fatty Liver Disease National Sun Yat‐sen University Kaohsiung TaiwanHepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung TaiwanInstitute of Environmental and Occupational Health Sciences National Taiwan University Taipei TaiwanHepatobiliary Division, Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung TaiwanAbstract We aimed to investigate the association between air pollution and advanced fibrosis among patients with metabolic associated fatty liver disease (MAFLD) and chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. A total of 1376 participants who were seropositive for HBV surface antigen (HBsAg) or antibodies to HCV (anti‐HCV) or had abnormal liver function in a community screening program from 2019 to 2021 were enrolled for the assessment of liver fibrosis using transient elastography. Daily estimates of air pollutants (particulate matter ≤2.5 μm in diameter [PM2.5], nitrogen dioxide [NO2], ozone [O3] and benzene) were aggregated into mean estimates for the previous year based on the date of enrolment. Of the 1376 participants, 767 (52.8%) and 187 (13.6) had MAFLD and advanced fibrosis, respectively. A logistic regression analysis revealed that the factors associated with advanced liver fibrosis were HCV viremia (odds ratio [OR], 3.13; 95% confidence interval [CI], 2.05–4.77; p < 0.001), smoking (OR, 1.79; 95% CI, 1.16–2.74; p = 0.01), age (OR, 1.04; 95% CI, 1.02–1.05; p < 0.001) and PM2.5 (OR, 1.10; 95% CI, 1.05–1.16; p < 0.001). Linear regression analysis revealed that LSM was independently correlated with PM2.5 (β: 0.134; 95% CI: 0.025, 0.243; p = 0.02). There was a dose‐dependent relationship between different fibrotic stages and the PM2.5 level (the PM2.5 level in patients with fibrotic stages 0, 1–2 and 3–4: 27.9, 28.4, and 29.3 μg/m3, respectively; trend p < 0.001). Exposure to PM2.5, as well as HBV and HCV infections, is associated with advanced liver fibrosis in patients with MAFLD. There was a dose‐dependent correlation between PM2.5 levels and the severity of hepatic fibrosis.https://doi.org/10.1002/kjm2.12781advanced liver fibrosisair pollutionMAFLDtransient elastographyPM2.5 |
| spellingShingle | Tyng‐Yuan Jang Chi‐Chang Ho Po‐Cheng Liang Chih‐Da Wu Yu‐Ju Wei Pei‐Chien Tsai Po‐Yao Hsu Ming‐Yen Hsieh Yi‐Hung Lin Meng‐Hsuan Hsieh Chih‐Wen Wang Jeng‐Fu Yang Ming‐Lun Yeh Chung‐Feng Huang Wan‐Long Chuang Jee‐Fu Huang Ya‐Yun Cheng Chia‐Yen Dai Pau‐Chung Chen Ming‐Lung Yu Air pollution associate with advanced hepatic fibrosis among patients with chronic liver disease Kaohsiung Journal of Medical Sciences advanced liver fibrosis air pollution MAFLD transient elastography PM2.5 |
| title | Air pollution associate with advanced hepatic fibrosis among patients with chronic liver disease |
| title_full | Air pollution associate with advanced hepatic fibrosis among patients with chronic liver disease |
| title_fullStr | Air pollution associate with advanced hepatic fibrosis among patients with chronic liver disease |
| title_full_unstemmed | Air pollution associate with advanced hepatic fibrosis among patients with chronic liver disease |
| title_short | Air pollution associate with advanced hepatic fibrosis among patients with chronic liver disease |
| title_sort | air pollution associate with advanced hepatic fibrosis among patients with chronic liver disease |
| topic | advanced liver fibrosis air pollution MAFLD transient elastography PM2.5 |
| url | https://doi.org/10.1002/kjm2.12781 |
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