Platelet-rich plasma in androgenetic alopecia
The goal of these recommendations is to provide a framework to practitioners for implementing useful, evidence-based recommendations for the preparation of platelet-rich plasma (PRP) and its use in androgenetic alopecia (AGA). The Indian Association of Dermatologists, Venereologists and Leprologists...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Indian Dermatology Online Journal |
| Subjects: | |
| Online Access: | http://www.idoj.in/article.asp?issn=2229-5178;year=2021;volume=12;issue=7;spage=31;epage=40;aulast=Sharma |
| _version_ | 1798019648606699520 |
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| author | Aseem Sharma Kavish Chouhan Satish Bhatia Shuken Dashore |
| author_facet | Aseem Sharma Kavish Chouhan Satish Bhatia Shuken Dashore |
| author_sort | Aseem Sharma |
| collection | DOAJ |
| description | The goal of these recommendations is to provide a framework to practitioners for implementing useful, evidence-based recommendations for the preparation of platelet-rich plasma (PRP) and its use in androgenetic alopecia (AGA). The Indian Association of Dermatologists, Venereologists and Leprologists (IADVL) assigned the task of preparing these recommendations to its taskforce on PRP. A comprehensive literature search was done in the English language on the PRP across multiple databases. The grade of evidence and strength of recommendation were evaluated on the GRADE (Grading of Recommendation, Assessment, Development, and Evaluation) framework. A draft of clinical recommendations was developed on the best available evidence, which was also scrutinized and critically evaluated by the IADVL Academy of Dermatology. Based on the inputs received, the final consensus statement was prepared. A total of 30 articles (meta-analyses, prospective and retrospective studies, reviews [including chapters in books], and case series) were critically evaluated, and the evidence thus gathered was used in the preparation of these recommendations. This expert group recommends use of manual double-spin method for the preparation of PRP for AGA. Minimum three to five sessions of PRP are recommended for AGA with a gap of 1 month between the two sessions. Patients with Grade II to V Norwood Hamilton classification of AGA are the ideal subset for PRP. A total of 5 to 7 mL of PRP and 0.05 to 0.1 mL/cm2 is the recommended dose of PRP for AGA. Activation of PRP is not required when it is used for AGA. About 1 to 1.5 million platelets/μL of platelets in PRP is the recommended platelet concentration in PRP for the treatment of AGA. I-PRF (injectable platelet-rich fibrin) has also been found to be useful in AGA, although further studies are required to establish its role. PRP can also have an adjunctive role in hair transplantation procedures. |
| first_indexed | 2024-04-11T16:44:13Z |
| format | Article |
| id | doaj.art-ad7a2a26a3c34dc7a12a298556ca9c8c |
| institution | Directory Open Access Journal |
| issn | 2229-5178 |
| language | English |
| last_indexed | 2024-04-11T16:44:13Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Dermatology Online Journal |
| spelling | doaj.art-ad7a2a26a3c34dc7a12a298556ca9c8c2022-12-22T04:13:36ZengWolters Kluwer Medknow PublicationsIndian Dermatology Online Journal2229-51782021-01-01127314010.4103/idoj.idoj_328_21Platelet-rich plasma in androgenetic alopeciaAseem SharmaKavish ChouhanSatish BhatiaShuken DashoreThe goal of these recommendations is to provide a framework to practitioners for implementing useful, evidence-based recommendations for the preparation of platelet-rich plasma (PRP) and its use in androgenetic alopecia (AGA). The Indian Association of Dermatologists, Venereologists and Leprologists (IADVL) assigned the task of preparing these recommendations to its taskforce on PRP. A comprehensive literature search was done in the English language on the PRP across multiple databases. The grade of evidence and strength of recommendation were evaluated on the GRADE (Grading of Recommendation, Assessment, Development, and Evaluation) framework. A draft of clinical recommendations was developed on the best available evidence, which was also scrutinized and critically evaluated by the IADVL Academy of Dermatology. Based on the inputs received, the final consensus statement was prepared. A total of 30 articles (meta-analyses, prospective and retrospective studies, reviews [including chapters in books], and case series) were critically evaluated, and the evidence thus gathered was used in the preparation of these recommendations. This expert group recommends use of manual double-spin method for the preparation of PRP for AGA. Minimum three to five sessions of PRP are recommended for AGA with a gap of 1 month between the two sessions. Patients with Grade II to V Norwood Hamilton classification of AGA are the ideal subset for PRP. A total of 5 to 7 mL of PRP and 0.05 to 0.1 mL/cm2 is the recommended dose of PRP for AGA. Activation of PRP is not required when it is used for AGA. About 1 to 1.5 million platelets/μL of platelets in PRP is the recommended platelet concentration in PRP for the treatment of AGA. I-PRF (injectable platelet-rich fibrin) has also been found to be useful in AGA, although further studies are required to establish its role. PRP can also have an adjunctive role in hair transplantation procedures.http://www.idoj.in/article.asp?issn=2229-5178;year=2021;volume=12;issue=7;spage=31;epage=40;aulast=Sharmaandrogenetic alopeciahair transplantmale pattern baldnesspdoplatelet-rich plasmaplatelet-rich plasma guidelinespreparationrcfrecommendationsregenerative medicinerpmthreads |
| spellingShingle | Aseem Sharma Kavish Chouhan Satish Bhatia Shuken Dashore Platelet-rich plasma in androgenetic alopecia Indian Dermatology Online Journal androgenetic alopecia hair transplant male pattern baldness pdo platelet-rich plasma platelet-rich plasma guidelines preparation rcf recommendations regenerative medicine rpm threads |
| title | Platelet-rich plasma in androgenetic alopecia |
| title_full | Platelet-rich plasma in androgenetic alopecia |
| title_fullStr | Platelet-rich plasma in androgenetic alopecia |
| title_full_unstemmed | Platelet-rich plasma in androgenetic alopecia |
| title_short | Platelet-rich plasma in androgenetic alopecia |
| title_sort | platelet rich plasma in androgenetic alopecia |
| topic | androgenetic alopecia hair transplant male pattern baldness pdo platelet-rich plasma platelet-rich plasma guidelines preparation rcf recommendations regenerative medicine rpm threads |
| url | http://www.idoj.in/article.asp?issn=2229-5178;year=2021;volume=12;issue=7;spage=31;epage=40;aulast=Sharma |
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