DAMP-Inducing Adjuvant and PAMP Adjuvants Parallelly Enhance Protective Type-2 and Type-1 Immune Responses to Influenza Split Vaccination

DAMP-Inducing Adjuvant and PAMP Adjuvants Parallelly Enhance Protective Type-2 and Type-1 Immune Responses to Influenza Split Vaccination

Recently, it was reported that 2-hydroxypropyl-β-cyclodextrin (HP-β-CyD), a common pharmaceutical additive, can act as a vaccine adjuvant to enhance protective type-2 immunogenicity to co-administered seasonal influenza split vaccine by inducing host-derived damage-associated molecular patterns (DAM...

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Bibliographic Details
Main Authors: Tomoya Hayashi, Masatoshi Momota, Etsushi Kuroda, Takato Kusakabe, Shingo Kobari, Kotaro Makisaka, Yoshitaka Ohno, Yusuke Suzuki, Fumika Nakagawa, Michelle S. J. Lee, Cevayir Coban, Risako Onodera, Taishi Higashi, Keiichi Motoyama, Ken J. Ishii, Hidetoshi Arima
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
2-hydroxypropyl-β-cyclodextrin
K3 CpG-ODN
adjuvant
damage-associated molecular patterns
pathogen-associated molecular patterns
influenza split vaccine
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02619/full

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