The Hypothalamic–Pituitary–Thyroid Axis Equivalent in Normal and Cancerous Oral Tissues: A Scoping Review
The hypothalamic–pituitary–thyroid (HPT) axis is crucial in regulating thyroid hormone levels that contribute to the development and homeostasis of the human body. Current literature supports the presence of a local HPT axis equivalent within keratinocytes of the skin, with thyroid hormones playing...
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| Format: | Article |
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MDPI AG
2022-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/22/14096 |
| _version_ | 1797465118871650304 |
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| author | Lisa Wu Stephen Xu Brian Yang Jenny Yang Claire Yee Nicola Cirillo |
| author_facet | Lisa Wu Stephen Xu Brian Yang Jenny Yang Claire Yee Nicola Cirillo |
| author_sort | Lisa Wu |
| collection | DOAJ |
| description | The hypothalamic–pituitary–thyroid (HPT) axis is crucial in regulating thyroid hormone levels that contribute to the development and homeostasis of the human body. Current literature supports the presence of a local HPT axis equivalent within keratinocytes of the skin, with thyroid hormones playing a potential role in cancer progression. However, this remains to be seen within oral tissue cells. An electronic search of Scopus and PubMed/Medline databases was conducted to identify all original publications that reported data on the production or effects of HPT axis components in normal or malignant cells of the oral cavity. The search identified 221 studies, of which 14 were eligible. Eight studies were retrospective analyses of clinical samples, one study involved both in vivo and in vitro experiments, and the remaining five studies were conducted in vitro using cell lines. The search identified evidence of effects of HPT components on oral cancer cells. However, there were limited data for the production of HPT axis components by oral tissues. We conclude that a possible role of the local HPT axis equivalent in the oral mucosa may not be established at present. The gaps in knowledge identified in this scoping review, particularly regarding the production of HPT components by oral tissues, warrant further investigation. |
| first_indexed | 2024-03-09T18:16:55Z |
| format | Article |
| id | doaj.art-ad7b726e38c446e49aa27b0fe37c3cee |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T18:16:55Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ad7b726e38c446e49aa27b0fe37c3cee2023-11-24T08:38:29ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-11-0123221409610.3390/ijms232214096The Hypothalamic–Pituitary–Thyroid Axis Equivalent in Normal and Cancerous Oral Tissues: A Scoping ReviewLisa Wu0Stephen Xu1Brian Yang2Jenny Yang3Claire Yee4Nicola Cirillo5Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, AustraliaMelbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, AustraliaMelbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, AustraliaMelbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, AustraliaMelbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, AustraliaMelbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, AustraliaThe hypothalamic–pituitary–thyroid (HPT) axis is crucial in regulating thyroid hormone levels that contribute to the development and homeostasis of the human body. Current literature supports the presence of a local HPT axis equivalent within keratinocytes of the skin, with thyroid hormones playing a potential role in cancer progression. However, this remains to be seen within oral tissue cells. An electronic search of Scopus and PubMed/Medline databases was conducted to identify all original publications that reported data on the production or effects of HPT axis components in normal or malignant cells of the oral cavity. The search identified 221 studies, of which 14 were eligible. Eight studies were retrospective analyses of clinical samples, one study involved both in vivo and in vitro experiments, and the remaining five studies were conducted in vitro using cell lines. The search identified evidence of effects of HPT components on oral cancer cells. However, there were limited data for the production of HPT axis components by oral tissues. We conclude that a possible role of the local HPT axis equivalent in the oral mucosa may not be established at present. The gaps in knowledge identified in this scoping review, particularly regarding the production of HPT components by oral tissues, warrant further investigation.https://www.mdpi.com/1422-0067/23/22/14096head and neck canceroral squamous cell carcinomathyroid hormonesthyroid hormone receptorsthyrotropin-releasing hormonethyroid-stimulating hormone |
| spellingShingle | Lisa Wu Stephen Xu Brian Yang Jenny Yang Claire Yee Nicola Cirillo The Hypothalamic–Pituitary–Thyroid Axis Equivalent in Normal and Cancerous Oral Tissues: A Scoping Review International Journal of Molecular Sciences head and neck cancer oral squamous cell carcinoma thyroid hormones thyroid hormone receptors thyrotropin-releasing hormone thyroid-stimulating hormone |
| title | The Hypothalamic–Pituitary–Thyroid Axis Equivalent in Normal and Cancerous Oral Tissues: A Scoping Review |
| title_full | The Hypothalamic–Pituitary–Thyroid Axis Equivalent in Normal and Cancerous Oral Tissues: A Scoping Review |
| title_fullStr | The Hypothalamic–Pituitary–Thyroid Axis Equivalent in Normal and Cancerous Oral Tissues: A Scoping Review |
| title_full_unstemmed | The Hypothalamic–Pituitary–Thyroid Axis Equivalent in Normal and Cancerous Oral Tissues: A Scoping Review |
| title_short | The Hypothalamic–Pituitary–Thyroid Axis Equivalent in Normal and Cancerous Oral Tissues: A Scoping Review |
| title_sort | hypothalamic pituitary thyroid axis equivalent in normal and cancerous oral tissues a scoping review |
| topic | head and neck cancer oral squamous cell carcinoma thyroid hormones thyroid hormone receptors thyrotropin-releasing hormone thyroid-stimulating hormone |
| url | https://www.mdpi.com/1422-0067/23/22/14096 |
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