The Usefulness of Cell-Based and Liquid-Based Urine Tests in Clarifying the Diagnosis and Monitoring the Course of Urothelial Carcinoma. Identification of Novel, Potentially Actionable, <i>RB1</i> and <i>ERBB2</i> Somatic Mutations
Bladder cancer is one of the most common cancers in global statistics. One of the issues associated with this disease is the high incidence of cases with delayed diagnosis and what factors correlate with worse treatment outcomes. A possible reason for this may be the rather limited availability of n...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/11/5/362 |
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| author | Tadeusz Kałużewski Grzegorz K. Przybylski Michał Bednarek Sławomir Glazar Magdalena Grabiec Adam Jędrzejczyk Łukasz Kępczyński Izabela Kubiak Dorota Kucharska Agnieszka Morel Magdalena Owczarek Marek Rożniecki Jordan Sałamunia Dominika Szewczyk Jarosław Szwalski Bogdan Kałużewski |
| author_facet | Tadeusz Kałużewski Grzegorz K. Przybylski Michał Bednarek Sławomir Glazar Magdalena Grabiec Adam Jędrzejczyk Łukasz Kępczyński Izabela Kubiak Dorota Kucharska Agnieszka Morel Magdalena Owczarek Marek Rożniecki Jordan Sałamunia Dominika Szewczyk Jarosław Szwalski Bogdan Kałużewski |
| author_sort | Tadeusz Kałużewski |
| collection | DOAJ |
| description | Bladder cancer is one of the most common cancers in global statistics. One of the issues associated with this disease is the high incidence of cases with delayed diagnosis and what factors correlate with worse treatment outcomes. A possible reason for this may be the rather limited availability of non-invasive diagnostic tools. This short communication presents a case of a 68 year old male patient after an ineffective therapy, carried on for several years with symptoms commonly associated with prostate overgrowth that masked a carcinoma in situ of the urinary bladder. Implementation of several diagnostic techniques, including urine sediment cytology, immunocytochemistry, the fluorescence in situ hybridisation technique, the Bladder EpiCheck test and whole-genome sequencing, enabled the establishment of a correct diagnosis, implementation of appropriate treatment and provision of patient-friendly monitoring. The described case emphasises the usefulness of cell-based and liquid-based urine tests in bladder cancer diagnostic procedures. |
| first_indexed | 2024-03-10T11:48:24Z |
| format | Article |
| id | doaj.art-ad7bb61fbe764367ade8bf427cd44a5c |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T11:48:24Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-ad7bb61fbe764367ade8bf427cd44a5c2023-11-21T17:54:11ZengMDPI AGJournal of Personalized Medicine2075-44262021-04-0111536210.3390/jpm11050362The Usefulness of Cell-Based and Liquid-Based Urine Tests in Clarifying the Diagnosis and Monitoring the Course of Urothelial Carcinoma. Identification of Novel, Potentially Actionable, <i>RB1</i> and <i>ERBB2</i> Somatic MutationsTadeusz Kałużewski0Grzegorz K. Przybylski1Michał Bednarek2Sławomir Glazar3Magdalena Grabiec4Adam Jędrzejczyk5Łukasz Kępczyński6Izabela Kubiak7Dorota Kucharska8Agnieszka Morel9Magdalena Owczarek10Marek Rożniecki11Jordan Sałamunia12Dominika Szewczyk13Jarosław Szwalski14Bogdan Kałużewski15Laboratory of Medical Genetics of the “Genos” Partnership—R&D Division, 91-033 Lodz, PolandInstitute of Human Genetics, Polish Academy of Sciences, 60-479 Poznan, PolandLaboratory of Medical Genetics of the “Genos” Partnership—R&D Division, 91-033 Lodz, PolandDepartment of Pathomorphology, District Hospital, 98-220 Zdunska Wola, PolandLaboratory of Medical Genetics of the “Genos” Partnership—R&D Division, 91-033 Lodz, PolandDepartment of Urology, District Hospital, 97-500 Radomsko, PolandLaboratory of Medical Genetics of the “Genos” Partnership—R&D Division, 91-033 Lodz, PolandLaboratory of Medical Genetics of the “Genos” Partnership—R&D Division, 91-033 Lodz, PolandLaboratory of Medical Genetics of the “Genos” Partnership—R&D Division, 91-033 Lodz, PolandLaboratory of Medical Genetics of the “Genos” Partnership—R&D Division, 91-033 Lodz, PolandLaboratory of Medical Genetics of the “Genos” Partnership—R&D Division, 91-033 Lodz, PolandLekarze Urolodzy Marek Rozniecki i Partnerzy, Non-Public Department of Urology, 98-100 Lask, PolandLaboratory of Medical Genetics of the “Genos” Partnership—R&D Division, 91-033 Lodz, PolandLaboratory of Medical Genetics of the “Genos” Partnership—R&D Division, 91-033 Lodz, PolandCYTOPATH S.A., Histopathological Laboratory, 90-552 Lodz, PolandLaboratory of Medical Genetics of the “Genos” Partnership—R&D Division, 91-033 Lodz, PolandBladder cancer is one of the most common cancers in global statistics. One of the issues associated with this disease is the high incidence of cases with delayed diagnosis and what factors correlate with worse treatment outcomes. A possible reason for this may be the rather limited availability of non-invasive diagnostic tools. This short communication presents a case of a 68 year old male patient after an ineffective therapy, carried on for several years with symptoms commonly associated with prostate overgrowth that masked a carcinoma in situ of the urinary bladder. Implementation of several diagnostic techniques, including urine sediment cytology, immunocytochemistry, the fluorescence in situ hybridisation technique, the Bladder EpiCheck test and whole-genome sequencing, enabled the establishment of a correct diagnosis, implementation of appropriate treatment and provision of patient-friendly monitoring. The described case emphasises the usefulness of cell-based and liquid-based urine tests in bladder cancer diagnostic procedures.https://www.mdpi.com/2075-4426/11/5/362bladder cancerurinary cytologyFISHBladder EpiChecknon-invasive urine testsWGS |
| spellingShingle | Tadeusz Kałużewski Grzegorz K. Przybylski Michał Bednarek Sławomir Glazar Magdalena Grabiec Adam Jędrzejczyk Łukasz Kępczyński Izabela Kubiak Dorota Kucharska Agnieszka Morel Magdalena Owczarek Marek Rożniecki Jordan Sałamunia Dominika Szewczyk Jarosław Szwalski Bogdan Kałużewski The Usefulness of Cell-Based and Liquid-Based Urine Tests in Clarifying the Diagnosis and Monitoring the Course of Urothelial Carcinoma. Identification of Novel, Potentially Actionable, <i>RB1</i> and <i>ERBB2</i> Somatic Mutations Journal of Personalized Medicine bladder cancer urinary cytology FISH Bladder EpiCheck non-invasive urine tests WGS |
| title | The Usefulness of Cell-Based and Liquid-Based Urine Tests in Clarifying the Diagnosis and Monitoring the Course of Urothelial Carcinoma. Identification of Novel, Potentially Actionable, <i>RB1</i> and <i>ERBB2</i> Somatic Mutations |
| title_full | The Usefulness of Cell-Based and Liquid-Based Urine Tests in Clarifying the Diagnosis and Monitoring the Course of Urothelial Carcinoma. Identification of Novel, Potentially Actionable, <i>RB1</i> and <i>ERBB2</i> Somatic Mutations |
| title_fullStr | The Usefulness of Cell-Based and Liquid-Based Urine Tests in Clarifying the Diagnosis and Monitoring the Course of Urothelial Carcinoma. Identification of Novel, Potentially Actionable, <i>RB1</i> and <i>ERBB2</i> Somatic Mutations |
| title_full_unstemmed | The Usefulness of Cell-Based and Liquid-Based Urine Tests in Clarifying the Diagnosis and Monitoring the Course of Urothelial Carcinoma. Identification of Novel, Potentially Actionable, <i>RB1</i> and <i>ERBB2</i> Somatic Mutations |
| title_short | The Usefulness of Cell-Based and Liquid-Based Urine Tests in Clarifying the Diagnosis and Monitoring the Course of Urothelial Carcinoma. Identification of Novel, Potentially Actionable, <i>RB1</i> and <i>ERBB2</i> Somatic Mutations |
| title_sort | usefulness of cell based and liquid based urine tests in clarifying the diagnosis and monitoring the course of urothelial carcinoma identification of novel potentially actionable i rb1 i and i erbb2 i somatic mutations |
| topic | bladder cancer urinary cytology FISH Bladder EpiCheck non-invasive urine tests WGS |
| url | https://www.mdpi.com/2075-4426/11/5/362 |
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