Population-based virucidal phthalocyanine gargling/rinsing protocol to reduce the risk of coronavirus disease-2019: a community trial
Aim: In this community trial, the objective was to evaluate the incidence of coronavirus disease-2019 (COVID-19) cases in two similar communities in three distinct phases: 1 (before the intervention), 2 (during the intervention), and 3 (after the intervention). Methods: The test community received t...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | deu |
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German Medical Science GMS Publishing House
2022-12-01
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| Series: | GMS Hygiene and Infection Control |
| Subjects: | |
| Online Access: | http://www.egms.de/static/en/journals/dgkh/2022-17/dgkh000426.shtml |
| _version_ | 1811291655617118208 |
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| author | Brito-Reia, Verônica Caroline da Silva Bastos, Roosevelt Vieira Vilhena, Fabiano Marques Honório, Heitor Marques da Costa Alves, Lucas Frazão, Paulo Sérgio da Silva Santos, Paulo |
| author_facet | Brito-Reia, Verônica Caroline da Silva Bastos, Roosevelt Vieira Vilhena, Fabiano Marques Honório, Heitor Marques da Costa Alves, Lucas Frazão, Paulo Sérgio da Silva Santos, Paulo |
| author_sort | Brito-Reia, Verônica Caroline |
| collection | DOAJ |
| description | Aim: In this community trial, the objective was to evaluate the incidence of coronavirus disease-2019 (COVID-19) cases in two similar communities in three distinct phases: 1 (before the intervention), 2 (during the intervention), and 3 (after the intervention). Methods: The test community received the oral antiseptic intervention (experimental), while the control community did not. The official information agency (“Statewise System for Data Analysis”) provided the number of confirmed COVID-19 cases. Data were analyzed according to the three phases per epidemiological week (epi) using the R Core Team (2021) program. The relative risk and 95% confidence intervals between the cumulative incidence values of the test and control communities were calculated for each period. In the test community, a total of 995 residents over 10 years of age received two bottles containing 600 ml of mouthwash containing antiviral phthalocyanine derivative (APD). The participants were asked to gargle/rinse with of 5 mL of the mouthwash containing ADP 3 to 5 times a day, for 1 min, until the bottles were empty. Results: In phases 1 and 3, the disease risk between the two communities did not differ significantly (p>0.05), while in phase 2, the disease risk was 54% lower in the test community than in the control community. Conclusion: The use of the APD mouthwash protocol seems to reduce the COVID-19 incidence at the population level, and further studies are needed to confirm its protective effect under more precisely controlled conditions. |
| first_indexed | 2024-04-13T04:32:16Z |
| format | Article |
| id | doaj.art-ad7ebb00340b430f8d555fe6cac429d7 |
| institution | Directory Open Access Journal |
| issn | 2196-5226 |
| language | deu |
| last_indexed | 2024-04-13T04:32:16Z |
| publishDate | 2022-12-01 |
| publisher | German Medical Science GMS Publishing House |
| record_format | Article |
| series | GMS Hygiene and Infection Control |
| spelling | doaj.art-ad7ebb00340b430f8d555fe6cac429d72022-12-22T03:02:17ZdeuGerman Medical Science GMS Publishing HouseGMS Hygiene and Infection Control2196-52262022-12-0117Doc2310.3205/dgkh000426Population-based virucidal phthalocyanine gargling/rinsing protocol to reduce the risk of coronavirus disease-2019: a community trialBrito-Reia, Verônica Caroline0da Silva Bastos, Roosevelt1Vieira Vilhena, Fabiano2Marques Honório, Heitor3Marques da Costa Alves, Lucas4Frazão, Paulo5Sérgio da Silva Santos, Paulo6Department of Surgery, Stomatology, Pathology, and Radiology, Bauru School of Dentistry, University of São Paulo, Bauru, BrazilDepartment of Pediatric Dentistry, Orthodontics and Public Health, Bauru School of Dentistry, University of São Paulo, Bauru, BrazilOral Health & Technologies, Bauru, BrazilDepartment of Pediatric Dentistry, Orthodontics and Public Health, Bauru School of Dentistry, University of São Paulo, Bauru, BrazilHospital Estadual de Bauru, Bauru, BrazilDepartment Public Health School at University of São Paulo, São Paulo, BrazilDepartment of Surgery, Stomatology, Pathology, and Radiology, Bauru School of Dentistry, University of São Paulo, Bauru, BrazilAim: In this community trial, the objective was to evaluate the incidence of coronavirus disease-2019 (COVID-19) cases in two similar communities in three distinct phases: 1 (before the intervention), 2 (during the intervention), and 3 (after the intervention). Methods: The test community received the oral antiseptic intervention (experimental), while the control community did not. The official information agency (“Statewise System for Data Analysis”) provided the number of confirmed COVID-19 cases. Data were analyzed according to the three phases per epidemiological week (epi) using the R Core Team (2021) program. The relative risk and 95% confidence intervals between the cumulative incidence values of the test and control communities were calculated for each period. In the test community, a total of 995 residents over 10 years of age received two bottles containing 600 ml of mouthwash containing antiviral phthalocyanine derivative (APD). The participants were asked to gargle/rinse with of 5 mL of the mouthwash containing ADP 3 to 5 times a day, for 1 min, until the bottles were empty. Results: In phases 1 and 3, the disease risk between the two communities did not differ significantly (p>0.05), while in phase 2, the disease risk was 54% lower in the test community than in the control community. Conclusion: The use of the APD mouthwash protocol seems to reduce the COVID-19 incidence at the population level, and further studies are needed to confirm its protective effect under more precisely controlled conditions.http://www.egms.de/static/en/journals/dgkh/2022-17/dgkh000426.shtmlcovid-19severe acute respiratory syndrome coronavirus 2antiviral mouthwashpopulation-based studyphthalocyanine derivate |
| spellingShingle | Brito-Reia, Verônica Caroline da Silva Bastos, Roosevelt Vieira Vilhena, Fabiano Marques Honório, Heitor Marques da Costa Alves, Lucas Frazão, Paulo Sérgio da Silva Santos, Paulo Population-based virucidal phthalocyanine gargling/rinsing protocol to reduce the risk of coronavirus disease-2019: a community trial GMS Hygiene and Infection Control covid-19 severe acute respiratory syndrome coronavirus 2 antiviral mouthwash population-based study phthalocyanine derivate |
| title | Population-based virucidal phthalocyanine gargling/rinsing protocol to reduce the risk of coronavirus disease-2019: a community trial |
| title_full | Population-based virucidal phthalocyanine gargling/rinsing protocol to reduce the risk of coronavirus disease-2019: a community trial |
| title_fullStr | Population-based virucidal phthalocyanine gargling/rinsing protocol to reduce the risk of coronavirus disease-2019: a community trial |
| title_full_unstemmed | Population-based virucidal phthalocyanine gargling/rinsing protocol to reduce the risk of coronavirus disease-2019: a community trial |
| title_short | Population-based virucidal phthalocyanine gargling/rinsing protocol to reduce the risk of coronavirus disease-2019: a community trial |
| title_sort | population based virucidal phthalocyanine gargling rinsing protocol to reduce the risk of coronavirus disease 2019 a community trial |
| topic | covid-19 severe acute respiratory syndrome coronavirus 2 antiviral mouthwash population-based study phthalocyanine derivate |
| url | http://www.egms.de/static/en/journals/dgkh/2022-17/dgkh000426.shtml |
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