Evaluation of Factors Related to Pancreatic Fistula Development in Patients Undergoing Pancreaticoduodenectomy for Periampullary Tumours
Objective:This study aimed to investigate the factors associated with pancreatic fistula (PF) development after pancreaticoduodenectomy (PD) at our clinic.Methods:Patients who underwent PD for periampullary tumours between 2010 and 2019 were included in the study and categorised into Group I (with P...
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| Format: | Article |
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Galenos Publishing House
2021-07-01
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| Series: | Bezmiâlem Science |
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http://bezmialemscience.org/archives/archive-detail/article-preview/evaluation-of-factors-related-to-pancreatic-fistul/47954
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| author | Uğur TOPAL Erdoğan Mütevelli SÖZÜER Türkmen Bahadır ARIKAN Mustafa GÖK Gamze Kübra BOZKURT |
| author_facet | Uğur TOPAL Erdoğan Mütevelli SÖZÜER Türkmen Bahadır ARIKAN Mustafa GÖK Gamze Kübra BOZKURT |
| author_sort | Uğur TOPAL |
| collection | DOAJ |
| description | Objective:This study aimed to investigate the factors associated with pancreatic fistula (PF) development after pancreaticoduodenectomy (PD) at our clinic.Methods:Patients who underwent PD for periampullary tumours between 2010 and 2019 were included in the study and categorised into Group I (with PF) and Group II (without PF). The demographic and clinical characteristics, laboratory parameters, tumour characteristics and post-operative results were compared between the groups. Risk factors for PF were analysed by univariate analysis and multivariate logistic regression analysis.Results:In total, 155 patients participated in the study (Group I: n=31; Group II: n=124). The rate of PF was 20%. The two groups were comparable with regard to sex (p=0.348) and age (64.8 vs 66.9 years, p=0.916). Compared with Group II, Group I had a higher number of metastatic lymph nodes (1.61 vs 0.87, p=0.041), a higher number of post-operative complications (58.1% vs 21.8%, p=0.000) and a longer duration of post-operative hospital stay (25.25 vs 16.43 days, p=0.000). Haemoglobin (p=0.493) and albumin (p=0.698) levels were similar between the groups. Total survival duration was shorter in Group I (23.9 vs 38.18 months, p=0.024). In multivariate analyses, being ≥65 years (p=0.040), tumour localisation (p=0.021), lymph node stage (p=0.008) and performedtumour diameter ≥2 (p=0.021) were the independent risk factors for developing pancreatic fistula.Conclusion:In our study, tumour diameter, patient age and lymph node status were associated with PF development. The development of PF reduced expected survival. We believe that identifying the preoperative, intraoperative and post-operative factors related to PF formation may help decrease its development. |
| first_indexed | 2024-04-10T12:21:23Z |
| format | Article |
| id | doaj.art-ad7ef196dfbf431498cd2557947196bf |
| institution | Directory Open Access Journal |
| issn | 2148-2373 2148-2373 |
| language | English |
| last_indexed | 2024-04-10T12:21:23Z |
| publishDate | 2021-07-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Bezmiâlem Science |
| spelling | doaj.art-ad7ef196dfbf431498cd2557947196bf2023-02-15T16:15:27ZengGalenos Publishing HouseBezmiâlem Science2148-23732148-23732021-07-019330130910.14235/bas.galenos.2020.418513049054Evaluation of Factors Related to Pancreatic Fistula Development in Patients Undergoing Pancreaticoduodenectomy for Periampullary TumoursUğur TOPAL0Erdoğan Mütevelli SÖZÜER1Türkmen Bahadır ARIKAN2Mustafa GÖK3Gamze Kübra BOZKURT4 Erciyes University Faculty of Medicine, Department of Surgical Oncology, Kayseri, Turkey Erciyes University Faculty of Medicine, Department of Surgical Oncology, Kayseri, Turkey Erciyes University Faculty of Medicine, Department of General Surgery, Kayseri, Turkey Erciyes University Faculty of Medicine, Department of General Surgery, Kayseri, Turkey Erciyes University Faculty of Medicine, Department of General Surgery, Kayseri, Turkey Objective:This study aimed to investigate the factors associated with pancreatic fistula (PF) development after pancreaticoduodenectomy (PD) at our clinic.Methods:Patients who underwent PD for periampullary tumours between 2010 and 2019 were included in the study and categorised into Group I (with PF) and Group II (without PF). The demographic and clinical characteristics, laboratory parameters, tumour characteristics and post-operative results were compared between the groups. Risk factors for PF were analysed by univariate analysis and multivariate logistic regression analysis.Results:In total, 155 patients participated in the study (Group I: n=31; Group II: n=124). The rate of PF was 20%. The two groups were comparable with regard to sex (p=0.348) and age (64.8 vs 66.9 years, p=0.916). Compared with Group II, Group I had a higher number of metastatic lymph nodes (1.61 vs 0.87, p=0.041), a higher number of post-operative complications (58.1% vs 21.8%, p=0.000) and a longer duration of post-operative hospital stay (25.25 vs 16.43 days, p=0.000). Haemoglobin (p=0.493) and albumin (p=0.698) levels were similar between the groups. Total survival duration was shorter in Group I (23.9 vs 38.18 months, p=0.024). In multivariate analyses, being ≥65 years (p=0.040), tumour localisation (p=0.021), lymph node stage (p=0.008) and performedtumour diameter ≥2 (p=0.021) were the independent risk factors for developing pancreatic fistula.Conclusion:In our study, tumour diameter, patient age and lymph node status were associated with PF development. The development of PF reduced expected survival. We believe that identifying the preoperative, intraoperative and post-operative factors related to PF formation may help decrease its development. http://bezmialemscience.org/archives/archive-detail/article-preview/evaluation-of-factors-related-to-pancreatic-fistul/47954 pancreatic fistulapancreaticoduodenectomyprognosis |
| spellingShingle | Uğur TOPAL Erdoğan Mütevelli SÖZÜER Türkmen Bahadır ARIKAN Mustafa GÖK Gamze Kübra BOZKURT Evaluation of Factors Related to Pancreatic Fistula Development in Patients Undergoing Pancreaticoduodenectomy for Periampullary Tumours Bezmiâlem Science pancreatic fistula pancreaticoduodenectomy prognosis |
| title | Evaluation of Factors Related to Pancreatic Fistula Development in Patients Undergoing Pancreaticoduodenectomy for Periampullary Tumours |
| title_full | Evaluation of Factors Related to Pancreatic Fistula Development in Patients Undergoing Pancreaticoduodenectomy for Periampullary Tumours |
| title_fullStr | Evaluation of Factors Related to Pancreatic Fistula Development in Patients Undergoing Pancreaticoduodenectomy for Periampullary Tumours |
| title_full_unstemmed | Evaluation of Factors Related to Pancreatic Fistula Development in Patients Undergoing Pancreaticoduodenectomy for Periampullary Tumours |
| title_short | Evaluation of Factors Related to Pancreatic Fistula Development in Patients Undergoing Pancreaticoduodenectomy for Periampullary Tumours |
| title_sort | evaluation of factors related to pancreatic fistula development in patients undergoing pancreaticoduodenectomy for periampullary tumours |
| topic | pancreatic fistula pancreaticoduodenectomy prognosis |
| url |
http://bezmialemscience.org/archives/archive-detail/article-preview/evaluation-of-factors-related-to-pancreatic-fistul/47954
|
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