DLP 3D Printing Meets Lignocellulosic Biopolymers: Carboxymethyl Cellulose Inks for 3D Biocompatible Hydrogels
The development of new bio-based inks is a stringent request for the expansion of additive manufacturing towards the development of 3D-printed biocompatible hydrogels. Herein, methacrylated carboxymethyl cellulose (M-CMC) is investigated as a bio-based photocurable ink for digital light processing (...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/12/8/1655 |
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| author | Giuseppe Melilli Irene Carmagnola Chiara Tonda-Turo Fabrizio Pirri Gianluca Ciardelli Marco Sangermano Minna Hakkarainen Annalisa Chiappone |
| author_facet | Giuseppe Melilli Irene Carmagnola Chiara Tonda-Turo Fabrizio Pirri Gianluca Ciardelli Marco Sangermano Minna Hakkarainen Annalisa Chiappone |
| author_sort | Giuseppe Melilli |
| collection | DOAJ |
| description | The development of new bio-based inks is a stringent request for the expansion of additive manufacturing towards the development of 3D-printed biocompatible hydrogels. Herein, methacrylated carboxymethyl cellulose (M-CMC) is investigated as a bio-based photocurable ink for digital light processing (DLP) 3D printing. CMC is chemically modified using methacrylic anhydride. Successful methacrylation is confirmed by <sup>1</sup>H NMR and FTIR spectroscopy. Aqueous formulations based on M-CMC/lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) photoinitiator and M-CMC/Dulbecco’s Modified Eagle Medium (DMEM)/LAP show high photoreactivity upon UV irradiation as confirmed by photorheology and FTIR. The same formulations can be easily 3D-printed through a DLP apparatus to produce 3D shaped hydrogels with excellent swelling ability and mechanical properties. Envisaging the application of the hydrogels in the biomedical field, cytotoxicity is also evaluated. The light-induced printing of cellulose-based hydrogels represents a significant step forward in the production of new DLP inks suitable for biomedical applications. |
| first_indexed | 2024-03-10T18:13:17Z |
| format | Article |
| id | doaj.art-ad7f5da4299647cc919e472fbc1f90d9 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T18:13:17Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-ad7f5da4299647cc919e472fbc1f90d92023-11-20T07:56:38ZengMDPI AGPolymers2073-43602020-07-01128165510.3390/polym12081655DLP 3D Printing Meets Lignocellulosic Biopolymers: Carboxymethyl Cellulose Inks for 3D Biocompatible HydrogelsGiuseppe Melilli0Irene Carmagnola1Chiara Tonda-Turo2Fabrizio Pirri3Gianluca Ciardelli4Marco Sangermano5Minna Hakkarainen6Annalisa Chiappone7Department of Fibre and Polymer Technology, KTH Royal Institute of Technology, Teknikringen 56-58, 10044 Stockholm, SwedenDepartment of Mechanical and Aerospace Engineering, Politecnico di Torino, C.so Duca dgeli Abruzzi 24, 10129 Torino, ItalyDepartment of Mechanical and Aerospace Engineering, Politecnico di Torino, C.so Duca dgeli Abruzzi 24, 10129 Torino, ItalyPOLITO BIOMed LAB, Politecnico di Torino, 10129 Turin, ItalyDepartment of Mechanical and Aerospace Engineering, Politecnico di Torino, C.so Duca dgeli Abruzzi 24, 10129 Torino, ItalyPOLITO BIOMed LAB, Politecnico di Torino, 10129 Turin, ItalyDepartment of Fibre and Polymer Technology, KTH Royal Institute of Technology, Teknikringen 56-58, 10044 Stockholm, SwedenPOLITO BIOMed LAB, Politecnico di Torino, 10129 Turin, ItalyThe development of new bio-based inks is a stringent request for the expansion of additive manufacturing towards the development of 3D-printed biocompatible hydrogels. Herein, methacrylated carboxymethyl cellulose (M-CMC) is investigated as a bio-based photocurable ink for digital light processing (DLP) 3D printing. CMC is chemically modified using methacrylic anhydride. Successful methacrylation is confirmed by <sup>1</sup>H NMR and FTIR spectroscopy. Aqueous formulations based on M-CMC/lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) photoinitiator and M-CMC/Dulbecco’s Modified Eagle Medium (DMEM)/LAP show high photoreactivity upon UV irradiation as confirmed by photorheology and FTIR. The same formulations can be easily 3D-printed through a DLP apparatus to produce 3D shaped hydrogels with excellent swelling ability and mechanical properties. Envisaging the application of the hydrogels in the biomedical field, cytotoxicity is also evaluated. The light-induced printing of cellulose-based hydrogels represents a significant step forward in the production of new DLP inks suitable for biomedical applications.https://www.mdpi.com/2073-4360/12/8/1655hydrogelmethacrylated CMC3D printingDLP |
| spellingShingle | Giuseppe Melilli Irene Carmagnola Chiara Tonda-Turo Fabrizio Pirri Gianluca Ciardelli Marco Sangermano Minna Hakkarainen Annalisa Chiappone DLP 3D Printing Meets Lignocellulosic Biopolymers: Carboxymethyl Cellulose Inks for 3D Biocompatible Hydrogels Polymers hydrogel methacrylated CMC 3D printing DLP |
| title | DLP 3D Printing Meets Lignocellulosic Biopolymers: Carboxymethyl Cellulose Inks for 3D Biocompatible Hydrogels |
| title_full | DLP 3D Printing Meets Lignocellulosic Biopolymers: Carboxymethyl Cellulose Inks for 3D Biocompatible Hydrogels |
| title_fullStr | DLP 3D Printing Meets Lignocellulosic Biopolymers: Carboxymethyl Cellulose Inks for 3D Biocompatible Hydrogels |
| title_full_unstemmed | DLP 3D Printing Meets Lignocellulosic Biopolymers: Carboxymethyl Cellulose Inks for 3D Biocompatible Hydrogels |
| title_short | DLP 3D Printing Meets Lignocellulosic Biopolymers: Carboxymethyl Cellulose Inks for 3D Biocompatible Hydrogels |
| title_sort | dlp 3d printing meets lignocellulosic biopolymers carboxymethyl cellulose inks for 3d biocompatible hydrogels |
| topic | hydrogel methacrylated CMC 3D printing DLP |
| url | https://www.mdpi.com/2073-4360/12/8/1655 |
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