Fe<sub>3</sub>O<sub>4</sub> Nanozymes Improve Neuroblast Differentiation and Blood-Brain Barrier Integrity of the Hippocampal Dentate Gyrus in <span style="font-variant: small-caps">D</span>-Galactose-Induced Aged Mice

Fe<sub>3</sub>O<sub>4</sub> Nanozymes Improve Neuroblast Differentiation and Blood-Brain Barrier Integrity of the Hippocampal Dentate Gyrus in <span style="font-variant: small-caps">D</span>-Galactose-Induced Aged Mice

Aging is a process associated with blood–brain barrier (BBB) damage and the reduction in neurogenesis, and is the greatest known risk factor for neurodegenerative disorders. However, the effects of Fe<sub>3</sub>O<sub>4</sub> nanozymes on neurogenesis have rarely been studied...

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Bibliographic Details
Main Authors: Zihao Xia, Manman Gao, Peng Sheng, Mengmeng Shen, Lin Zhao, Lizeng Gao, Bingchun Yan
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:International Journal of Molecular Sciences
Subjects:
Fe<sub>3</sub>O<sub>4</sub> nanozyme
neuroblast differentiation
blood–brain barrier
antioxidant
aging
Online Access:https://www.mdpi.com/1422-0067/23/12/6463
Description
Summary:Aging is a process associated with blood–brain barrier (BBB) damage and the reduction in neurogenesis, and is the greatest known risk factor for neurodegenerative disorders. However, the effects of Fe<sub>3</sub>O<sub>4</sub> nanozymes on neurogenesis have rarely been studied. This study examined the effects of Fe<sub>3</sub>O<sub>4</sub> nanozymes on neuronal differentiation in the dentate gyrus (DG) and BBB integrity of D-galactose-induced aged mice. Long-term treatment with Fe<sub>3</sub>O<sub>4</sub> nanozymes (10 μg/mL diluted in ddH<sub>2</sub>O daily) markedly increased the doublecortin (DCX) immunoreactivity and decreased BBB injury induced by <span style="font-variant: small-caps;">D</span>-galactose treatment. In addition, the decreases in the levels of antioxidant proteins including superoxide dismutase (SOD) and catalase as well as autophagy-related proteins such as Becin-1, LC3II/I, and Atg7 induced by <span style="font-variant: small-caps;">D</span>-galactose treatment were significantly ameliorated by Fe<sub>3</sub>O<sub>4</sub> nanozymes in the DG of the mouse hippocampus. Furthermore, Fe<sub>3</sub>O<sub>4</sub> nanozyme treatment showed an inhibitory effect against apoptosis in the hippocampus. In conclusion, Fe<sub>3</sub>O<sub>4</sub> nanozymes can relieve neuroblast damage and promote neuroblast differentiation in the hippocampal DG by regulating oxidative stress, apoptosis, and autophagy.
ISSN:1661-6596
1422-0067

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