Genetically Encoded Calcium Indicators: A New Tool in Renal Hypertension Research
Hypertension is ranked as the third cause of disability-adjusted life-years. The percentage of the population suffering from hypertension will continue to increase over the next years. Renovascular disease is one of the most common causes of secondary hypertension. Vascular changes seen in hypertens...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-06-01
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| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fmed.2019.00128/full |
| _version_ | 1818380631166418944 |
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| author | Cheng Zhong Johanna Schleifenbaum |
| author_facet | Cheng Zhong Johanna Schleifenbaum |
| author_sort | Cheng Zhong |
| collection | DOAJ |
| description | Hypertension is ranked as the third cause of disability-adjusted life-years. The percentage of the population suffering from hypertension will continue to increase over the next years. Renovascular disease is one of the most common causes of secondary hypertension. Vascular changes seen in hypertension are partially based on dysfunctional calcium signaling. This signaling can be studied using calcium indicators (loading dyes and genetically encoded calcium indicators; GECIs). Most progress in development has been seen in GECIs, which are used in an increasing number of publications concerning calcium signaling in vasculature and the kidney. The use of transgenic mouse models expressing GECIs will facilitate new possibilities to study dysfunctional calcium signaling in a cell type-specific manner, thus helping to identify more specific targets for treatment of (renal) hypertension. |
| first_indexed | 2024-12-14T02:21:45Z |
| format | Article |
| id | doaj.art-ad8072708ca24e1b93b358fdc5f364a3 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-14T02:21:45Z |
| publishDate | 2019-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-ad8072708ca24e1b93b358fdc5f364a32022-12-21T23:20:29ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2019-06-01610.3389/fmed.2019.00128452253Genetically Encoded Calcium Indicators: A New Tool in Renal Hypertension ResearchCheng ZhongJohanna SchleifenbaumHypertension is ranked as the third cause of disability-adjusted life-years. The percentage of the population suffering from hypertension will continue to increase over the next years. Renovascular disease is one of the most common causes of secondary hypertension. Vascular changes seen in hypertension are partially based on dysfunctional calcium signaling. This signaling can be studied using calcium indicators (loading dyes and genetically encoded calcium indicators; GECIs). Most progress in development has been seen in GECIs, which are used in an increasing number of publications concerning calcium signaling in vasculature and the kidney. The use of transgenic mouse models expressing GECIs will facilitate new possibilities to study dysfunctional calcium signaling in a cell type-specific manner, thus helping to identify more specific targets for treatment of (renal) hypertension.https://www.frontiersin.org/article/10.3389/fmed.2019.00128/fullcalciumGCaMPhypertensionkidneyimaging |
| spellingShingle | Cheng Zhong Johanna Schleifenbaum Genetically Encoded Calcium Indicators: A New Tool in Renal Hypertension Research Frontiers in Medicine calcium GCaMP hypertension kidney imaging |
| title | Genetically Encoded Calcium Indicators: A New Tool in Renal Hypertension Research |
| title_full | Genetically Encoded Calcium Indicators: A New Tool in Renal Hypertension Research |
| title_fullStr | Genetically Encoded Calcium Indicators: A New Tool in Renal Hypertension Research |
| title_full_unstemmed | Genetically Encoded Calcium Indicators: A New Tool in Renal Hypertension Research |
| title_short | Genetically Encoded Calcium Indicators: A New Tool in Renal Hypertension Research |
| title_sort | genetically encoded calcium indicators a new tool in renal hypertension research |
| topic | calcium GCaMP hypertension kidney imaging |
| url | https://www.frontiersin.org/article/10.3389/fmed.2019.00128/full |
| work_keys_str_mv | AT chengzhong geneticallyencodedcalciumindicatorsanewtoolinrenalhypertensionresearch AT johannaschleifenbaum geneticallyencodedcalciumindicatorsanewtoolinrenalhypertensionresearch |