Obesity induced by estrogen deficiency is associated with hypothalamic inflammation
Occurrence of obesity during the postmenopausal period is closely associated with inflammatory processes in multiple peripheral organs that are metabolically active. Hypothalamic inflammation has been recognized as one of the major underlying causes of various metabolic disorders, including obesity....
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-09-01
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| Series: | Biochemistry and Biophysics Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405580820301035 |
| _version_ | 1818449313157611520 |
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| author | Hye Rim Yang Thai Hien Tu Da Yeon Jeong Sunggu Yang Jae Geun Kim |
| author_facet | Hye Rim Yang Thai Hien Tu Da Yeon Jeong Sunggu Yang Jae Geun Kim |
| author_sort | Hye Rim Yang |
| collection | DOAJ |
| description | Occurrence of obesity during the postmenopausal period is closely associated with inflammatory processes in multiple peripheral organs that are metabolically active. Hypothalamic inflammation has been recognized as one of the major underlying causes of various metabolic disorders, including obesity. The association between menopause-related obesity and hypothalamic inflammation remains poorly understood. We observed an elevation in hypothalamic inflammation in the ovariectomized mice, which displayed altered metabolic phenotypes and visceral obesity. Furthermore, we confirmed that ovariectomized mice displayed microglial activation accompanied by the upregulation of multiple genes involved in the inflammatory responses in hypothalamic microglia. Collectively, the current findings suggest that hypothalamic inflammation associated with microglial functioning could be a major pathogenic element in disruption of energy homeostasis during the postmenopausal period. |
| first_indexed | 2024-12-14T20:33:25Z |
| format | Article |
| id | doaj.art-ad81750fbde242fbb07cdf49fe9399b6 |
| institution | Directory Open Access Journal |
| issn | 2405-5808 |
| language | English |
| last_indexed | 2024-12-14T20:33:25Z |
| publishDate | 2020-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biochemistry and Biophysics Reports |
| spelling | doaj.art-ad81750fbde242fbb07cdf49fe9399b62022-12-21T22:48:28ZengElsevierBiochemistry and Biophysics Reports2405-58082020-09-0123100794Obesity induced by estrogen deficiency is associated with hypothalamic inflammationHye Rim Yang0Thai Hien Tu1Da Yeon Jeong2Sunggu Yang3Jae Geun Kim4Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon, 22012, South KoreaDivision of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon, 22012, South KoreaDivision of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon, 22012, South KoreaDepartment of Nano-Bioengineering, Incheon National University, Incheon, 22012, South KoreaDivision of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon, 22012, South Korea; Institute for New Drug Development, Division of Life Sciences, Incheon National University, Incheon, 22012, South Korea; Corresponding author. Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon, 22012, South Korea.Occurrence of obesity during the postmenopausal period is closely associated with inflammatory processes in multiple peripheral organs that are metabolically active. Hypothalamic inflammation has been recognized as one of the major underlying causes of various metabolic disorders, including obesity. The association between menopause-related obesity and hypothalamic inflammation remains poorly understood. We observed an elevation in hypothalamic inflammation in the ovariectomized mice, which displayed altered metabolic phenotypes and visceral obesity. Furthermore, we confirmed that ovariectomized mice displayed microglial activation accompanied by the upregulation of multiple genes involved in the inflammatory responses in hypothalamic microglia. Collectively, the current findings suggest that hypothalamic inflammation associated with microglial functioning could be a major pathogenic element in disruption of energy homeostasis during the postmenopausal period.http://www.sciencedirect.com/science/article/pii/S2405580820301035MenopauseEstrogenHypothalamusInflammationMicrogliaObesity |
| spellingShingle | Hye Rim Yang Thai Hien Tu Da Yeon Jeong Sunggu Yang Jae Geun Kim Obesity induced by estrogen deficiency is associated with hypothalamic inflammation Biochemistry and Biophysics Reports Menopause Estrogen Hypothalamus Inflammation Microglia Obesity |
| title | Obesity induced by estrogen deficiency is associated with hypothalamic inflammation |
| title_full | Obesity induced by estrogen deficiency is associated with hypothalamic inflammation |
| title_fullStr | Obesity induced by estrogen deficiency is associated with hypothalamic inflammation |
| title_full_unstemmed | Obesity induced by estrogen deficiency is associated with hypothalamic inflammation |
| title_short | Obesity induced by estrogen deficiency is associated with hypothalamic inflammation |
| title_sort | obesity induced by estrogen deficiency is associated with hypothalamic inflammation |
| topic | Menopause Estrogen Hypothalamus Inflammation Microglia Obesity |
| url | http://www.sciencedirect.com/science/article/pii/S2405580820301035 |
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