Zika virus: clinical manifestations and treatment at a primary care institution in Colombia
Introduction: Although Zika virus cases have been reported in Colombia since 2015, its clinical and pharmacological characteristics have not yet been described. Objective: To describe the main clinical manifestations and sociodemographic characteristics of patients diagnosed with Zika and the treatm...
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| Format: | Article |
| Language: | English |
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Universidad Nacional de Colombia
2020-04-01
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| Series: | Revista de la Facultad de Medicina |
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| Online Access: | https://revistas.unal.edu.co/index.php/revfacmed/article/view/74926 |
| _version_ | 1827945350818693120 |
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| author | Juan Daniel Castrillón-Espitia Alejandra López-Villegas Estefanía Morales-Jiménez Germán Eduardo Rueda-Merchán Valentina Ramírez-Zapata Carmen Luisa Betancur-Pulgarín |
| author_facet | Juan Daniel Castrillón-Espitia Alejandra López-Villegas Estefanía Morales-Jiménez Germán Eduardo Rueda-Merchán Valentina Ramírez-Zapata Carmen Luisa Betancur-Pulgarín |
| author_sort | Juan Daniel Castrillón-Espitia |
| collection | DOAJ |
| description | Introduction: Although Zika virus cases have been reported in Colombia since 2015, its clinical and pharmacological characteristics have not yet been described.
Objective: To describe the main clinical manifestations and sociodemographic characteristics of patients diagnosed with Zika and the treatment provided to them at a primary care hospital in a municipality of Colombia.
Materials and methods: Descriptive cross-sectional study. The study population consisted of patients diagnosed with Zika between January 1 and July 25, 2016 at a primary care hospital. Sociodemographic, clinical, and pharmacological variables, as well as adverse clinical outcomes associated with the infection were included. Descriptive statistics were performed. A χ² test was used for categorical variables, and a multivariate analysis was conducted using Epi info 7.1 software.
Results: 254 individuals infected with Zika virus during the study period were identified, and Zika diagnosis was more frequent in women (68.5%). Regarding treatment, 90.9% of the cases were treated using acetaminophen. The most commonly reported symptoms were rash (81.1%) and pruritus (55.9%). In addition, antihistamines were the most frequent comedication (31.9%). Factors such as being a woman, being pregnant and inpatient treatment were associated with adverse clinical outcomes.
Conclusion: The clinical manifestations described here are similar to those reported in other populations. Furthermore, inappropriate pharmacological management practices that can lead to complications in this population, such as bleeding, were observed in some cases. Thus, educational interventions on the proper prescription of medications for treating this disease aimed at general physicians working in Zika affected areas must be implemented to improve the prognosis of these patients.
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| first_indexed | 2024-03-13T10:43:28Z |
| format | Article |
| id | doaj.art-ad83e6535ef44be6a70d72561305878d |
| institution | Directory Open Access Journal |
| issn | 0120-0011 2357-3848 |
| language | English |
| last_indexed | 2024-03-13T10:43:28Z |
| publishDate | 2020-04-01 |
| publisher | Universidad Nacional de Colombia |
| record_format | Article |
| series | Revista de la Facultad de Medicina |
| spelling | doaj.art-ad83e6535ef44be6a70d72561305878d2023-05-17T22:04:12ZengUniversidad Nacional de ColombiaRevista de la Facultad de Medicina0120-00112357-38482020-04-0168210.15446/revfacmed.v68n2.74926Zika virus: clinical manifestations and treatment at a primary care institution in ColombiaJuan Daniel Castrillón-Espitia0Alejandra López-Villegas1Estefanía Morales-Jiménez2Germán Eduardo Rueda-Merchán3Valentina Ramírez-Zapata4Carmen Luisa Betancur-Pulgarín5Fundación Universitaria del Área Andina - Pereira Campus - Faculty of Health Sciences - Grupo de Investigación Zona de Investigaciones de Postgrados de la Andina - Pereira - Colombia. 2 Fundación Universitaria Autónoma de las Américas - Pereira Campus - Faculty of Medicine - Grupo de Investigación Biomedicina - Pereira - Colombia.Fundación Universitaria Autónoma de las Américas - Pereira Campus - Faculty of Medicine - Grupo de Investigación Biomedicina - Pereira - Colombia.Fundación Universitaria Autónoma de las Américas - Pereira Campus - Faculty of Medicine - Grupo de Investigación Biomedicina - Pereira - Colombia.Fundación Universitaria Autónoma de las Américas - Pereira Campus - Faculty of Medicine - Grupo de Investigación Biomedicina - Pereira - Colombia.Fundación Universitaria Autónoma de las Américas - Pereira Campus - Faculty of Medicine - Grupo de Investigación Biomedicina - Pereira - Colombia.Fundación Universitaria del Área Andina - Pereira Campus - Faculty of Health Sciences - Grupo de Investigación Zona de Investigaciones de Postgrados de la Andina - Pereira - Colombia.Introduction: Although Zika virus cases have been reported in Colombia since 2015, its clinical and pharmacological characteristics have not yet been described. Objective: To describe the main clinical manifestations and sociodemographic characteristics of patients diagnosed with Zika and the treatment provided to them at a primary care hospital in a municipality of Colombia. Materials and methods: Descriptive cross-sectional study. The study population consisted of patients diagnosed with Zika between January 1 and July 25, 2016 at a primary care hospital. Sociodemographic, clinical, and pharmacological variables, as well as adverse clinical outcomes associated with the infection were included. Descriptive statistics were performed. A χ² test was used for categorical variables, and a multivariate analysis was conducted using Epi info 7.1 software. Results: 254 individuals infected with Zika virus during the study period were identified, and Zika diagnosis was more frequent in women (68.5%). Regarding treatment, 90.9% of the cases were treated using acetaminophen. The most commonly reported symptoms were rash (81.1%) and pruritus (55.9%). In addition, antihistamines were the most frequent comedication (31.9%). Factors such as being a woman, being pregnant and inpatient treatment were associated with adverse clinical outcomes. Conclusion: The clinical manifestations described here are similar to those reported in other populations. Furthermore, inappropriate pharmacological management practices that can lead to complications in this population, such as bleeding, were observed in some cases. Thus, educational interventions on the proper prescription of medications for treating this disease aimed at general physicians working in Zika affected areas must be implemented to improve the prognosis of these patients. https://revistas.unal.edu.co/index.php/revfacmed/article/view/74926Zika VirusAcetaminophenAnti-Inflammatory AgentsDrug TherapyEpidemiology |
| spellingShingle | Juan Daniel Castrillón-Espitia Alejandra López-Villegas Estefanía Morales-Jiménez Germán Eduardo Rueda-Merchán Valentina Ramírez-Zapata Carmen Luisa Betancur-Pulgarín Zika virus: clinical manifestations and treatment at a primary care institution in Colombia Revista de la Facultad de Medicina Zika Virus Acetaminophen Anti-Inflammatory Agents Drug Therapy Epidemiology |
| title | Zika virus: clinical manifestations and treatment at a primary care institution in Colombia |
| title_full | Zika virus: clinical manifestations and treatment at a primary care institution in Colombia |
| title_fullStr | Zika virus: clinical manifestations and treatment at a primary care institution in Colombia |
| title_full_unstemmed | Zika virus: clinical manifestations and treatment at a primary care institution in Colombia |
| title_short | Zika virus: clinical manifestations and treatment at a primary care institution in Colombia |
| title_sort | zika virus clinical manifestations and treatment at a primary care institution in colombia |
| topic | Zika Virus Acetaminophen Anti-Inflammatory Agents Drug Therapy Epidemiology |
| url | https://revistas.unal.edu.co/index.php/revfacmed/article/view/74926 |
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