Efficacy and safety of low-dose aspirin on preventing transplant renal artery stenosis: a prospective randomized controlled trial
Abstract. Background:. Transplant renal artery stenosis (TRAS) is a vascular complication after kidney transplantation associated with poor outcomes. This study aimed to analyze the efficacy and safety of low-dose aspirin for preventing TRAS. Methods:. After kidney transplantation, patients were enr...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer
2023-03-01
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| Series: | Chinese Medical Journal |
| Online Access: | http://journals.lww.com/10.1097/CM9.0000000000002574 |
| _version_ | 1797840155811250176 |
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| author | Xiangyong Tian Bingqing Ji Xiaoge Niu Wenjing Duan Xiaoqiang Wu Guanghui Cao Chan Zhang Jingge Zhao Zhiwei Wang Yue Gu Huixia Cao Tao Qin Fengmin Shao Tianzhong Yan Jinjiao Li Yuanyuan Ji |
| author_facet | Xiangyong Tian Bingqing Ji Xiaoge Niu Wenjing Duan Xiaoqiang Wu Guanghui Cao Chan Zhang Jingge Zhao Zhiwei Wang Yue Gu Huixia Cao Tao Qin Fengmin Shao Tianzhong Yan Jinjiao Li Yuanyuan Ji |
| author_sort | Xiangyong Tian |
| collection | DOAJ |
| description | Abstract. Background:. Transplant renal artery stenosis (TRAS) is a vascular complication after kidney transplantation associated with poor outcomes. This study aimed to analyze the efficacy and safety of low-dose aspirin for preventing TRAS.
Methods:. After kidney transplantation, patients were enrolled from January 2018 to December 2020 in Henan Provincial People's Hospital. A total of 351 enrolled recipients were randomized to an aspirin group with low-dose intake of aspirin in addition to standard treatment (n = 178), or a control group with only standard treatment (n = 173). The patients was initially diagnosed as TRAS (id-TRAS) by Doppler ultrasound, and confirmed cases were diagnosed by DSA (c-TRAS).
Results:. In the aspirin and control groups, 15.7% (28/178) and 22.0% (38/173) of the recipients developed id-TRAS, respectively, with no statistical difference. However, for c-TRAS, the difference of incidence and cumulative incidence was statistically significant. The incidence of c-TRAS was lower in the aspirin group compared with the control group (2.8% [5/178] vs. 11.6% [20/173], P = 0.001). Kaplan–Meier estimates and Cox regression model identified the cumulative incidence and hazard ratio (HR) of TRAS over time in two groups, showing that recipients treated with aspirin had a significantly lower risk of c-TRAS than those who were not treated (log-rank P = 0.001, HR = 0.23, 95% confidence interval [CI]: 0.09–0.62). The levels of platelet aggregation rate (P < 0.001), cholesterol (P = 0.028), and low-density lipoprotein cholesterol (P = 0.003) in the aspirin group were decreased compared with the control group in the third-month post-transplantation. For the incidence of adverse events, there was no statistical difference.
Conclusion:. Clinical application of low-dose aspirin after renal transplant could prevent the development of TRAS with no significant increase in adverse effects.
Trial Registration:. Clinicaltrials.gov, NCT04260828. |
| first_indexed | 2024-04-09T16:10:11Z |
| format | Article |
| id | doaj.art-ad857ef8a6ad4136bf26abbadaf957e6 |
| institution | Directory Open Access Journal |
| issn | 0366-6999 2542-5641 |
| language | English |
| last_indexed | 2024-04-09T16:10:11Z |
| publishDate | 2023-03-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Chinese Medical Journal |
| spelling | doaj.art-ad857ef8a6ad4136bf26abbadaf957e62023-04-24T10:07:12ZengWolters KluwerChinese Medical Journal0366-69992542-56412023-03-01136554154910.1097/CM9.0000000000002574202303050-00006Efficacy and safety of low-dose aspirin on preventing transplant renal artery stenosis: a prospective randomized controlled trialXiangyong TianBingqing JiXiaoge NiuWenjing DuanXiaoqiang WuGuanghui CaoChan ZhangJingge ZhaoZhiwei WangYue GuHuixia CaoTao QinFengmin ShaoTianzhong YanJinjiao LiYuanyuan JiAbstract. Background:. Transplant renal artery stenosis (TRAS) is a vascular complication after kidney transplantation associated with poor outcomes. This study aimed to analyze the efficacy and safety of low-dose aspirin for preventing TRAS. Methods:. After kidney transplantation, patients were enrolled from January 2018 to December 2020 in Henan Provincial People's Hospital. A total of 351 enrolled recipients were randomized to an aspirin group with low-dose intake of aspirin in addition to standard treatment (n = 178), or a control group with only standard treatment (n = 173). The patients was initially diagnosed as TRAS (id-TRAS) by Doppler ultrasound, and confirmed cases were diagnosed by DSA (c-TRAS). Results:. In the aspirin and control groups, 15.7% (28/178) and 22.0% (38/173) of the recipients developed id-TRAS, respectively, with no statistical difference. However, for c-TRAS, the difference of incidence and cumulative incidence was statistically significant. The incidence of c-TRAS was lower in the aspirin group compared with the control group (2.8% [5/178] vs. 11.6% [20/173], P = 0.001). Kaplan–Meier estimates and Cox regression model identified the cumulative incidence and hazard ratio (HR) of TRAS over time in two groups, showing that recipients treated with aspirin had a significantly lower risk of c-TRAS than those who were not treated (log-rank P = 0.001, HR = 0.23, 95% confidence interval [CI]: 0.09–0.62). The levels of platelet aggregation rate (P < 0.001), cholesterol (P = 0.028), and low-density lipoprotein cholesterol (P = 0.003) in the aspirin group were decreased compared with the control group in the third-month post-transplantation. For the incidence of adverse events, there was no statistical difference. Conclusion:. Clinical application of low-dose aspirin after renal transplant could prevent the development of TRAS with no significant increase in adverse effects. Trial Registration:. Clinicaltrials.gov, NCT04260828.http://journals.lww.com/10.1097/CM9.0000000000002574 |
| spellingShingle | Xiangyong Tian Bingqing Ji Xiaoge Niu Wenjing Duan Xiaoqiang Wu Guanghui Cao Chan Zhang Jingge Zhao Zhiwei Wang Yue Gu Huixia Cao Tao Qin Fengmin Shao Tianzhong Yan Jinjiao Li Yuanyuan Ji Efficacy and safety of low-dose aspirin on preventing transplant renal artery stenosis: a prospective randomized controlled trial Chinese Medical Journal |
| title | Efficacy and safety of low-dose aspirin on preventing transplant renal artery stenosis: a prospective randomized controlled trial |
| title_full | Efficacy and safety of low-dose aspirin on preventing transplant renal artery stenosis: a prospective randomized controlled trial |
| title_fullStr | Efficacy and safety of low-dose aspirin on preventing transplant renal artery stenosis: a prospective randomized controlled trial |
| title_full_unstemmed | Efficacy and safety of low-dose aspirin on preventing transplant renal artery stenosis: a prospective randomized controlled trial |
| title_short | Efficacy and safety of low-dose aspirin on preventing transplant renal artery stenosis: a prospective randomized controlled trial |
| title_sort | efficacy and safety of low dose aspirin on preventing transplant renal artery stenosis a prospective randomized controlled trial |
| url | http://journals.lww.com/10.1097/CM9.0000000000002574 |
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