Swept-source optical coherence tomography angiography for choroidal neovascularization after bevacizumab and photodynamic therapy
Purpose: To report the swept-source optical coherence tomography angiography (SS-OCTA) findings after bevacizumab anti-vascular endothelial growth factor (anti-VEGF) and full-fluence photodynamic therapy (PDT) for choroidal neovascularization. Design: Case report. Methods: An 87-year-old, Chinese ma...
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| Format: | Article |
| Language: | English |
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Elsevier
2016-04-01
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| Series: | American Journal of Ophthalmology Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S245199361530013X |
| _version_ | 1811298029863436288 |
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| author | Jesse J. Jung Michael H. Chen Patty Y. Chung Scott S. Lee |
| author_facet | Jesse J. Jung Michael H. Chen Patty Y. Chung Scott S. Lee |
| author_sort | Jesse J. Jung |
| collection | DOAJ |
| description | Purpose: To report the swept-source optical coherence tomography angiography (SS-OCTA) findings after bevacizumab anti-vascular endothelial growth factor (anti-VEGF) and full-fluence photodynamic therapy (PDT) for choroidal neovascularization.
Design: Case report.
Methods: An 87-year-old, Chinese male presented with a shadow and decreased vision to 20/160 in his left eye (OS). Clinical examination, color photographs, swept-source optical coherence tomography (SS-OCT), widefield dye-fluorescein angiography (FA) and SS-OCTA revealed an extrafoveal, subretinal choroidal neovascularization (CNV) in the superior macula. Bevacizumab anti-VEGF and full-fluence PDT was initiated.
Results: Initial imaging with conventional color photography and FA demonstrated a classic CNV with significant early hyperfluorescence and late leakage. SS-OCT demonstrated subretinal hyperreflective material, fluid and hemorrhage emanating from a subretinal, type 2 neovascularization (NV). SS-OCTA showed a mixed lesion with a type 2, subretinal component with segmentation above the retinal pigment epithelium (RPE) and a type 1, sub-RPE component below. Treatment with anti-VEGF and PDT led to immediate regression of the CNV. One month after treatment, SS-OCTA demonstrated significant resolution of the type, 2 subretinal component and decreased flow and size of the type 1 sub-RPE lesion.
Conclusion: We report the first SS-OCTA images of successfully treated extrafoveal NV after combination PDT and ant-VEGF therapy. Early treatment of extrafoveal NV may improve our ability to treat mixed type 1 and 2 NV before these neovascular complexes mature from repetitive anti-VEGF treatment. |
| first_indexed | 2024-04-13T06:13:40Z |
| format | Article |
| id | doaj.art-ad86353a574b4ab38054e1400aa99407 |
| institution | Directory Open Access Journal |
| issn | 2451-9936 |
| language | English |
| last_indexed | 2024-04-13T06:13:40Z |
| publishDate | 2016-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Journal of Ophthalmology Case Reports |
| spelling | doaj.art-ad86353a574b4ab38054e1400aa994072022-12-22T02:58:55ZengElsevierAmerican Journal of Ophthalmology Case Reports2451-99362016-04-011C1410.1016/j.ajoc.2016.01.002Swept-source optical coherence tomography angiography for choroidal neovascularization after bevacizumab and photodynamic therapyJesse J. Jung0Michael H. Chen1Patty Y. Chung2Scott S. Lee3East Bay Retina Consultants, Inc., 3300 Telegraph Ave., Oakland, CA 94609, USASilicon Valley Eyecare, 770 Scott Blvd., Santa Clara, CA 95050, USAEast Bay Retina Consultants, Inc., 3300 Telegraph Ave., Oakland, CA 94609, USAEast Bay Retina Consultants, Inc., 3300 Telegraph Ave., Oakland, CA 94609, USAPurpose: To report the swept-source optical coherence tomography angiography (SS-OCTA) findings after bevacizumab anti-vascular endothelial growth factor (anti-VEGF) and full-fluence photodynamic therapy (PDT) for choroidal neovascularization. Design: Case report. Methods: An 87-year-old, Chinese male presented with a shadow and decreased vision to 20/160 in his left eye (OS). Clinical examination, color photographs, swept-source optical coherence tomography (SS-OCT), widefield dye-fluorescein angiography (FA) and SS-OCTA revealed an extrafoveal, subretinal choroidal neovascularization (CNV) in the superior macula. Bevacizumab anti-VEGF and full-fluence PDT was initiated. Results: Initial imaging with conventional color photography and FA demonstrated a classic CNV with significant early hyperfluorescence and late leakage. SS-OCT demonstrated subretinal hyperreflective material, fluid and hemorrhage emanating from a subretinal, type 2 neovascularization (NV). SS-OCTA showed a mixed lesion with a type 2, subretinal component with segmentation above the retinal pigment epithelium (RPE) and a type 1, sub-RPE component below. Treatment with anti-VEGF and PDT led to immediate regression of the CNV. One month after treatment, SS-OCTA demonstrated significant resolution of the type, 2 subretinal component and decreased flow and size of the type 1 sub-RPE lesion. Conclusion: We report the first SS-OCTA images of successfully treated extrafoveal NV after combination PDT and ant-VEGF therapy. Early treatment of extrafoveal NV may improve our ability to treat mixed type 1 and 2 NV before these neovascular complexes mature from repetitive anti-VEGF treatment.http://www.sciencedirect.com/science/article/pii/S245199361530013XAnti-VEGFBevacizumabNeovascularizationOptical coherence tomographyPhotodynamic therapySwept-source optical coherence tomography angiography |
| spellingShingle | Jesse J. Jung Michael H. Chen Patty Y. Chung Scott S. Lee Swept-source optical coherence tomography angiography for choroidal neovascularization after bevacizumab and photodynamic therapy American Journal of Ophthalmology Case Reports Anti-VEGF Bevacizumab Neovascularization Optical coherence tomography Photodynamic therapy Swept-source optical coherence tomography angiography |
| title | Swept-source optical coherence tomography angiography for choroidal neovascularization after bevacizumab and photodynamic therapy |
| title_full | Swept-source optical coherence tomography angiography for choroidal neovascularization after bevacizumab and photodynamic therapy |
| title_fullStr | Swept-source optical coherence tomography angiography for choroidal neovascularization after bevacizumab and photodynamic therapy |
| title_full_unstemmed | Swept-source optical coherence tomography angiography for choroidal neovascularization after bevacizumab and photodynamic therapy |
| title_short | Swept-source optical coherence tomography angiography for choroidal neovascularization after bevacizumab and photodynamic therapy |
| title_sort | swept source optical coherence tomography angiography for choroidal neovascularization after bevacizumab and photodynamic therapy |
| topic | Anti-VEGF Bevacizumab Neovascularization Optical coherence tomography Photodynamic therapy Swept-source optical coherence tomography angiography |
| url | http://www.sciencedirect.com/science/article/pii/S245199361530013X |
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