Coronary artery disease in patients with cystic fibrosis – A case series and review of the literature
Progressive obstructive pulmonary disease is the primary life-shortening complication in people with Cystic Fibrosis (CF); improvement in life expectancy has led to increased prevalence of non-pulmonary complications. Patients with CF are considered to be at low risk for coronary artery disease (CAD...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-12-01
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| Series: | Journal of Clinical & Translational Endocrinology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214623722000163 |
| _version_ | 1811201991441907712 |
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| author | Zahrae Sandouk Noura Nachawi Richard Simon Jennifer Wyckoff Melissa S. Putman Sarah Kiel Sarah Soltman Antoinette Moran Amir Moheet |
| author_facet | Zahrae Sandouk Noura Nachawi Richard Simon Jennifer Wyckoff Melissa S. Putman Sarah Kiel Sarah Soltman Antoinette Moran Amir Moheet |
| author_sort | Zahrae Sandouk |
| collection | DOAJ |
| description | Progressive obstructive pulmonary disease is the primary life-shortening complication in people with Cystic Fibrosis (CF); improvement in life expectancy has led to increased prevalence of non-pulmonary complications. Patients with CF are considered to be at low risk for coronary artery disease (CAD). We report here a case series of six patients with CF with and without known cystic fibrosis related diabetes (CFRD) who had acute myocardial infarction (AMI) requiring coronary stent placement. This was a heterogeneous group of patients, without a clear pattern of consistent risk factors. Interestingly, most patients in this cohort had low LDL. In this review, we discuss risk factors of cardiovascular disease (CVD) that may apply to the CF population. While CAD is rare in people with CF, it does occur. We postulate that the risk will grow with increased longevity and the increased prevalence of co-morbidities such as obesity and dyslipidemia. |
| first_indexed | 2024-04-12T02:31:13Z |
| format | Article |
| id | doaj.art-ad86e030370749dd8e7341a0a9dba094 |
| institution | Directory Open Access Journal |
| issn | 2214-6237 |
| language | English |
| last_indexed | 2024-04-12T02:31:13Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Clinical & Translational Endocrinology |
| spelling | doaj.art-ad86e030370749dd8e7341a0a9dba0942022-12-22T03:51:45ZengElsevierJournal of Clinical & Translational Endocrinology2214-62372022-12-0130100308Coronary artery disease in patients with cystic fibrosis – A case series and review of the literatureZahrae Sandouk0Noura Nachawi1Richard Simon2Jennifer Wyckoff3Melissa S. Putman4Sarah Kiel5Sarah Soltman6Antoinette Moran7Amir Moheet8Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, MI, USA; Corresponding author at: MEND Division, University of Michigan, Lobby C. 24 Frank Lloyd Wright Drive, Ann Arbor, MI 48105, USA.Division of Endocrinology, Cleveland Clinic, Cleveland, OH, USADivision of Pulmonology, University of Michigan, Ann Arbor, MI, USADivision of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, MI, USADivisions of Endocrinology, Massachusetts General Hospital and Boston Children’s Hospital, MA, USADivision of Pulmonary, Allergy, and Critical Care Medicine, University of Minnesota. Minneapolis, MN, USADivision of Endocrinology, Oregon Health and Sciences University, Portland, OR, USADepartment of Pediatrics, University of Minnesota, Minneapolis, MN, USADepartment of Medicine, University of Minnesota, Minneapolis, MN, USAProgressive obstructive pulmonary disease is the primary life-shortening complication in people with Cystic Fibrosis (CF); improvement in life expectancy has led to increased prevalence of non-pulmonary complications. Patients with CF are considered to be at low risk for coronary artery disease (CAD). We report here a case series of six patients with CF with and without known cystic fibrosis related diabetes (CFRD) who had acute myocardial infarction (AMI) requiring coronary stent placement. This was a heterogeneous group of patients, without a clear pattern of consistent risk factors. Interestingly, most patients in this cohort had low LDL. In this review, we discuss risk factors of cardiovascular disease (CVD) that may apply to the CF population. While CAD is rare in people with CF, it does occur. We postulate that the risk will grow with increased longevity and the increased prevalence of co-morbidities such as obesity and dyslipidemia.http://www.sciencedirect.com/science/article/pii/S2214623722000163Cystic fibrosisCystic fibrosis related diabetesCoronary artery diseaseHyperlipidemiaLow cholesterol levelRisk factors |
| spellingShingle | Zahrae Sandouk Noura Nachawi Richard Simon Jennifer Wyckoff Melissa S. Putman Sarah Kiel Sarah Soltman Antoinette Moran Amir Moheet Coronary artery disease in patients with cystic fibrosis – A case series and review of the literature Journal of Clinical & Translational Endocrinology Cystic fibrosis Cystic fibrosis related diabetes Coronary artery disease Hyperlipidemia Low cholesterol level Risk factors |
| title | Coronary artery disease in patients with cystic fibrosis – A case series and review of the literature |
| title_full | Coronary artery disease in patients with cystic fibrosis – A case series and review of the literature |
| title_fullStr | Coronary artery disease in patients with cystic fibrosis – A case series and review of the literature |
| title_full_unstemmed | Coronary artery disease in patients with cystic fibrosis – A case series and review of the literature |
| title_short | Coronary artery disease in patients with cystic fibrosis – A case series and review of the literature |
| title_sort | coronary artery disease in patients with cystic fibrosis a case series and review of the literature |
| topic | Cystic fibrosis Cystic fibrosis related diabetes Coronary artery disease Hyperlipidemia Low cholesterol level Risk factors |
| url | http://www.sciencedirect.com/science/article/pii/S2214623722000163 |
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